Tumor necrosis factor-alpha-induced cyclooxygenase-2 overexpression in eutopic endometrium of women with endometriosis by stromal cell culture through nuclear factor-kappaB activation.

Young Ah Kim, Ji Yeon Kim, Mee‐Ran Kim, Mi Ran Kim, Kyung Joo Hwang, Doo Young Chang, Myung Kwon Jeon
The Journal of reproductive medicine · 2009 · vol. 54(10) , pp. 625–30 · PMID:20677482 · W127401376
article OA: closed CC0 ⤵ 11 in-corpus citations
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TNF-alpha induces COX-2 overexpression in eutopic endometrial stromal cells from women with endometriosis via NF-kappaB activation, with a greater induction observed compared to women without endometriosis.

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Abstract

OBJECTIVE: To investigate the role of NF-kappaB during the induction of COX-2 by TNF-alpha in the eutopic endometrium of women with and without endometriosis using stromal cell culture. STUDY DESIGN: Experimental study in cultured stromal cells of the eutopic endometrium of women with and without endometriosis in the presence of TNF-alpha. RESULTS: Within 5-20 minutes of stimulation with TNF-alpha, p-IkappaB was clearly observed in the eutopic endometrium of women with endometriosis and in that of women without endometriosis. COX-2 protein was significantly induced by treatment with TNF-alpha in both eutopic endometrial stromal cells of women with and without endometriosis (p < 0.05), but the degree of induction was significantly increased in eutopic endometrial stromal cells of women with endometriosis than those of women without endometriosis (p < 0.05). CONCLUSION: Overexpression of COX-2 by TNF-alpha in the eutopic endometrium of women with endometriosis may play a critical role in such pathophysiologic processes as endometriosis formation.

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Condition tags

endometriosis

MeSH descriptors

Cyclooxygenase 2 Endometriosis NF-kappa B Stromal Cells Tumor Necrosis Factor-alpha Adult Cells, Cultured Cyclooxygenase 2 Endometriosis Endometrium Endometrium Endometrium Female Humans NF-kappa B Stromal Cells Tumor Necrosis Factor-alpha

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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