Role of estrogen and estrogen-related factors in endometriosis

Taisuke Mori; Jo Kitawaki

doi:10.1016/b978-0-12-820661-4.00022-4

Role of estrogen and estrogen-related factors in endometriosis

Taisuke Mori, Jo Kitawaki

In: Immunology of Endometriosis · 2021 · pp. 105–119 · doi:10.1016/b978-0-12-820661-4.00022-4 · W4200361410

book-chapter OA: closed CC0

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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This paper investigates the involvement of estrogen and estrogen-related factors in the development and progression of endometriosis.

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endometriosis

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References (80)

Aromatase: a key molecule in the pathophysiology of endometriosis and a therapeutic target via openalex
Cyclic Adenosine 3′,5′-Monophosphate Response Element-Binding Protein and CCAAT/Enhancer-Binding Protein Mediate Prostaglandin E2-Induced Steroidogenic Acute Regulatory Protein Expression in Endometriotic Stromal Cells via openalex
Daidzein-rich isoflavone aglycones inhibit cell growth and inflammation in endometriosis via openalex
Dienogest, a synthetic progestin, inhibits prostaglandin E2 production and aromatase expression by human endometrial epithelial cells in a spheroid culture system via openalex
Dienogest, a synthetic progestin, inhibits the proliferation of immortalized human endometrial epithelial cells with suppression of cyclin D1 gene expression via openalex
Dienogest inhibits aromatase and cyclooxygenase-2 expression and prostaglandin E2 production in human endometriotic stromal cells in spheroid culture via openalex
Dienogest inhibits nerve growth factor expression induced by tumor necrosis factor-α or interleukin-1β via openalex
Dienogest inhibits Toll-like receptor 4 expression induced by costimulation of lipopolysaccharide and high-mobility group box 1 in endometrial epithelial cells via openalex
Dienogest is as effective as intranasal buserelin acetate for the relief of pain symptoms associated with endometriosis—a randomized, double-blind, multicenter, controlled trial via openalex
Dienogest is a selective progesterone receptor agonist in transactivation analysis with potent oral endometrial activity due to its efficient pharmacokinetic profile via openalex
Dienogest reduces HSD17β1 expression and activity in endometriosis via openalex
Differential expression of steroidogenic enzymes according to endometriosis type via openalex
Endometrial and Endometriotic Concentrations of Estrone and Estradiol Are Determined by Local Metabolism Rather than Circulating Levels via openalex
Endometriosis via openalex
Endometriosis via openalex
Endometriosis: hormone regulation and clinical consequences of chemotaxis and apoptosis via openalex
ERβ- and Prostaglandin E2-Regulated Pathways Integrate Cell Proliferation via Ras-like and Estrogen-Regulated Growth Inhibitor in Endometriosis via openalex
Estradiol promotes cells invasion by activating β-catenin signaling pathway in endometriosis via openalex
Estrogen biosynthesis and signaling in endometriosis via openalex
Estrogen metabolizing enzymes in endometrium and endometriosis via openalex
Estrogen Receptor β Modulates Apoptosis Complexes and the Inflammasome to Drive the Pathogenesis of Endometriosis via openalex
Expression of Aromatase Cytochrome P450 Protein and Messenger Ribonucleic Acid in Human Endometriotic and Adenomyotic Tissues but not in Normal Endometrium1 via openalex
Expression of estrogen receptor alpha and beta in peritoneal and ovarian endometriosis via openalex
Expression of the G protein-coupled estrogen receptor (GPER) in endometriosis: a tissue microarray study via openalex
Genistein causes regression of endometriotic implants in the rat model via openalex
G protein–coupled estrogen receptor 1 agonist G-1 induces cell cycle arrest in the mitotic phase, leading to apoptosis in endometriosis via openalex
G Protein-Coupled Estrogen Receptor (GPER) Expression in Normal and Abnormal Endometrium via openalex
Incidence of endometriosis by study population and diagnostic method: the ENDO study via openalex
Inhibition of steroid sulphatase activity in endometriotic implants by 667 COUMATE: a potential new therapy via openalex
Interleukin-4 and Prostaglandin E2 Synergistically Up-Regulate 3β-Hydroxysteroid Dehydrogenase Type 2 in Endometrioma Stromal Cells via openalex
Involvement of estrogen receptor-related receptors in human ovarian endometriosis via openalex
Maintenance therapy involving a tapering dose of danazol or mid/low doses of oral contraceptive after gonadotropin-releasing hormone agonist treatment for endometriosis-associated pelvic pain via openalex
Medical treatment of endometriosis-related pain via openalex
Molecular Biology of Endometriosis: From Aromatase to Genomic Abnormalities via openalex
Oral contraceptives and risk of endometriosis: a systematic review and meta-analysis via openalex
Parthenolide reduces cell proliferation and prostaglandin estradiol synthesis in human endometriotic stromal cells and inhibits development of endometriosis in the murine model via openalex
Pathogenesis and pathophysiology of endometriosis via openalex
Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1α Enhances Local Estrogen Biosynthesis by Stimulating Aromatase Activity in Endometriosis via openalex
Peroxisome proliferator-activated receptor-γ coactivator 1α-mediated pathway as a possible therapeutic target in endometriosis via openalex
Progesterone and progestational compounds attenuate tumor necrosis factor alpha–induced interleukin-8 production via nuclear factor kappaB inactivation in endometriotic stromal cells via openalex
Promoter Methylation Regulates Estrogen Receptor 2 in Human Endometrium and Endometriosis1 via openalex
Prostaglandin E2 Stimulates Aromatase Expression in Endometriosis-Derived Stromal Cells via openalex
Prostaglandin E2 Via Steroidogenic Factor-1 Coordinately Regulates Transcription of Steroidogenic Genes Necessary for Estrogen Synthesis in Endometriosis via openalex
Puerarin Suppresses Proliferation of Endometriotic Stromal Cells Partly via the MAPK Signaling Pathway Induced by 17ß-estradiol-BSA via openalex
Regulation of Steroidogenic Acute Regulatory Protein Expression and Progesterone Production in Endometriotic Stromal Cells via openalex
Role of Estrogen Receptor Signaling Required for Endometriosis-Like Lesion Establishment in a Mouse Model via openalex
Systematic review of the effects of aromatase inhibitors on pain associated with endometriosis via openalex
The dynamics of nuclear receptors and nuclear receptor coregulators in the pathogenesis of endometriosis via openalex
Transactivation of Steroidogenic Acute Regulatory Protein in Human Endometriotic Stromal Cells Is Mediated by the Prostaglandin EP2 Receptor via openalex
Treatment of Endometriosis via openalex
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W1993354065 via openalex
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W2015031223 via openalex
W2017011351 via openalex
W2028617796 via openalex
W2045458073 via openalex
W2048863570 via openalex
W2049619918 via openalex
W2054885202 via openalex
W2068935255 via openalex
W2072982099 via openalex
W2075019139 via openalex
W2089030394 via openalex
W2107497260 via openalex
W2109525253 via openalex
W2117098665 via openalex
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W2136357797 via openalex
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Source provenance

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License: CC0 · commercial use OK

[1] Aromatase: a key molecule in the pathophysiology of endometriosis and a therapeutic target via openalex

[2] Cyclic Adenosine 3′,5′-Monophosphate Response Element-Binding Protein and CCAAT/Enhancer-Binding Protein Mediate Prostaglandin E2-Induced Steroidogenic Acute Regulatory Protein Expression in Endometriotic Stromal Cells via openalex

[3] Daidzein-rich isoflavone aglycones inhibit cell growth and inflammation in endometriosis via openalex

[4] Dienogest, a synthetic progestin, inhibits prostaglandin E2 production and aromatase expression by human endometrial epithelial cells in a spheroid culture system via openalex

[5] Dienogest, a synthetic progestin, inhibits the proliferation of immortalized human endometrial epithelial cells with suppression of cyclin D1 gene expression via openalex

[6] Dienogest inhibits aromatase and cyclooxygenase-2 expression and prostaglandin E2 production in human endometriotic stromal cells in spheroid culture via openalex

[7] Dienogest inhibits nerve growth factor expression induced by tumor necrosis factor-α or interleukin-1β via openalex

[8] Dienogest inhibits Toll-like receptor 4 expression induced by costimulation of lipopolysaccharide and high-mobility group box 1 in endometrial epithelial cells via openalex

[9] Dienogest is as effective as intranasal buserelin acetate for the relief of pain symptoms associated with endometriosis—a randomized, double-blind, multicenter, controlled trial via openalex

[10] Dienogest is a selective progesterone receptor agonist in transactivation analysis with potent oral endometrial activity due to its efficient pharmacokinetic profile via openalex

[11] Dienogest reduces HSD17β1 expression and activity in endometriosis via openalex

[12] Differential expression of steroidogenic enzymes according to endometriosis type via openalex

[13] Endometrial and Endometriotic Concentrations of Estrone and Estradiol Are Determined by Local Metabolism Rather than Circulating Levels via openalex

[14] Endometriosis via openalex

[15] Endometriosis via openalex

[16] Endometriosis: hormone regulation and clinical consequences of chemotaxis and apoptosis via openalex

[17] ERβ- and Prostaglandin E2-Regulated Pathways Integrate Cell Proliferation via Ras-like and Estrogen-Regulated Growth Inhibitor in Endometriosis via openalex

[18] Estradiol promotes cells invasion by activating β-catenin signaling pathway in endometriosis via openalex

[19] Estrogen biosynthesis and signaling in endometriosis via openalex

[20] Estrogen metabolizing enzymes in endometrium and endometriosis via openalex

[21] Estrogen Receptor β Modulates Apoptosis Complexes and the Inflammasome to Drive the Pathogenesis of Endometriosis via openalex

[22] Expression of Aromatase Cytochrome P450 Protein and Messenger Ribonucleic Acid in Human Endometriotic and Adenomyotic Tissues but not in Normal Endometrium1 via openalex

[23] Expression of estrogen receptor alpha and beta in peritoneal and ovarian endometriosis via openalex

[24] Expression of the G protein-coupled estrogen receptor (GPER) in endometriosis: a tissue microarray study via openalex

[25] Genistein causes regression of endometriotic implants in the rat model via openalex

[26] G protein–coupled estrogen receptor 1 agonist G-1 induces cell cycle arrest in the mitotic phase, leading to apoptosis in endometriosis via openalex

[27] G Protein-Coupled Estrogen Receptor (GPER) Expression in Normal and Abnormal Endometrium via openalex

[28] Incidence of endometriosis by study population and diagnostic method: the ENDO study via openalex

[29] Inhibition of steroid sulphatase activity in endometriotic implants by 667 COUMATE: a potential new therapy via openalex

[30] Interleukin-4 and Prostaglandin E2 Synergistically Up-Regulate 3β-Hydroxysteroid Dehydrogenase Type 2 in Endometrioma Stromal Cells via openalex

[31] Involvement of estrogen receptor-related receptors in human ovarian endometriosis via openalex

[32] Maintenance therapy involving a tapering dose of danazol or mid/low doses of oral contraceptive after gonadotropin-releasing hormone agonist treatment for endometriosis-associated pelvic pain via openalex

[33] Medical treatment of endometriosis-related pain via openalex

[34] Molecular Biology of Endometriosis: From Aromatase to Genomic Abnormalities via openalex

[35] Oral contraceptives and risk of endometriosis: a systematic review and meta-analysis via openalex

[36] Parthenolide reduces cell proliferation and prostaglandin estradiol synthesis in human endometriotic stromal cells and inhibits development of endometriosis in the murine model via openalex

[37] Pathogenesis and pathophysiology of endometriosis via openalex

[38] Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1α Enhances Local Estrogen Biosynthesis by Stimulating Aromatase Activity in Endometriosis via openalex

[39] Peroxisome proliferator-activated receptor-γ coactivator 1α-mediated pathway as a possible therapeutic target in endometriosis via openalex

[40] Progesterone and progestational compounds attenuate tumor necrosis factor alpha–induced interleukin-8 production via nuclear factor kappaB inactivation in endometriotic stromal cells via openalex

[41] Promoter Methylation Regulates Estrogen Receptor 2 in Human Endometrium and Endometriosis1 via openalex

[42] Prostaglandin E2 Stimulates Aromatase Expression in Endometriosis-Derived Stromal Cells via openalex

[43] Prostaglandin E2 Via Steroidogenic Factor-1 Coordinately Regulates Transcription of Steroidogenic Genes Necessary for Estrogen Synthesis in Endometriosis via openalex

[44] Puerarin Suppresses Proliferation of Endometriotic Stromal Cells Partly via the MAPK Signaling Pathway Induced by 17ß-estradiol-BSA via openalex

[45] Regulation of Steroidogenic Acute Regulatory Protein Expression and Progesterone Production in Endometriotic Stromal Cells via openalex

[46] Role of Estrogen Receptor Signaling Required for Endometriosis-Like Lesion Establishment in a Mouse Model via openalex

[47] Systematic review of the effects of aromatase inhibitors on pain associated with endometriosis via openalex

[48] The dynamics of nuclear receptors and nuclear receptor coregulators in the pathogenesis of endometriosis via openalex

[49] Transactivation of Steroidogenic Acute Regulatory Protein in Human Endometriotic Stromal Cells Is Mediated by the Prostaglandin EP2 Receptor via openalex

[50] Treatment of Endometriosis via openalex

[51] W6814680148 via openalex

[52] W1968872958 via openalex

[53] W1981306061 via openalex

[54] W1981467972 via openalex

[55] W1993354065 via openalex

[56] W1999582107 via openalex

[57] W1999672543 via openalex

[58] W2015031223 via openalex

[59] W2017011351 via openalex

[60] W2028617796 via openalex

[61] W2045458073 via openalex

[62] W2048863570 via openalex

[63] W2049619918 via openalex

[64] W2054885202 via openalex

[65] W2068935255 via openalex

[66] W2072982099 via openalex

[67] W2075019139 via openalex

[68] W2089030394 via openalex

[69] W2107497260 via openalex

[70] W2109525253 via openalex

[71] W2117098665 via openalex

[72] W2126100083 via openalex

[73] W2136357797 via openalex

[74] W2136812627 via openalex

[75] W2144020878 via openalex

[76] W2161623422 via openalex

[77] W2163315477 via openalex

[78] W2512316953 via openalex

[79] W2787941699 via openalex

[80] W3008616613 via openalex