G protein–coupled estrogen receptor 1 agonist G-1 induces cell cycle arrest in the mitotic phase, leading to apoptosis in endometriosis

Taisuke Mori, Fumitake Ito, Hiroshi Matsushima, Osamu Takaoka, Yukiko Tanaka, Akemi Koshiba, Izumi Kusuki, Jo Kitawaki
Fertility and sterility · 2015 · vol. 103(5) , pp. 1228–1235.e1 · doi:10.1016/j.fertnstert.2015.01.026 · PMID:25724739 · W2059770258
article OA: closed CC0 ⤵ 16 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

The G protein-coupled estrogen receptor 1 agonist G-1 was found to induce cell cycle arrest in the mitotic phase, ultimately leading to apoptosis in endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Apoptosis Cell Proliferation Cyclopentanes Endometriosis M Phase Cell Cycle Checkpoints Ovarian Cysts Ovary Quinolines Receptors, G-Protein-Coupled Stromal Cells Adult Apoptosis Caspase 3 Caspase 3 Cell Proliferation Cells, Cultured Cyclopentanes Dose-Response Relationship, Drug Endometriosis Endometriosis

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References (41)

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europepmc
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License: CC0 · commercial use OK