AC002454.1 and CDK6 synergistically promote endometrial cell migration and invasion in endometriosis

Jing Liu, Yang Wang, Peng Chen, Yue Ma, Shuo Wang, Ye Tian, Anna Wang, Danbo Wang
Reproduction (Cambridge, England) · 2019 · vol. 157(6) , pp. 535–543 · doi:10.1530/rep-19-0005 · PMID:30884467 · W2922312024
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

AC002454.1 and CDK6 are highly expressed in endometriosis tissues and synergistically promote endometrial cell proliferation, migration, and invasion.

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Abstract

Previous lncRNA microarray screening found that the AC002454.1 gene was highly expressed in endometriosis (EMS), and these expression levels were highly correlated with cyclin-dependent kinase-6 (CDK6). This study investigated the expression level and correlation between AC002454.1 and CDK6 in endometrium tissues and the influence of these changes in expression upon the biological behavior of eutopic endometrial cells. We confirmed AC002454.1 and CDK6 mRNA and protein were highly expressed in ectopic and eutopic endometrial tissue from patients with EMS and were clearly correlated. In vitro, both AC002454.1 and CDK6 positively regulated the proliferation, migration and invasion ability of eutopic endometrial cells and could promote the transformation of cells from G0/G1 phase to S phase. AC002454.1 and CDK6 may have synergistic effects, thereby affecting the biological behavior of endometrial cells, and thus promote the progression of EMS.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Cell Movement Cyclin-Dependent Kinase 6 Endometriosis Endometrium Gene Expression Regulation RNA, Long Noncoding Stromal Cells Apoptosis Cell Cycle Cell Proliferation Cyclin-Dependent Kinase 6 Cyclin-Dependent Kinase 6 Endometriosis Endometriosis Endometriosis Endometrium Endometrium Female Humans RNA, Long Noncoding

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (30)

Cited by (17)

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