LncRNA MALAT1 inhibits apoptosis of endometrial stromal cells through miR-126-5p-CREB1 axis by activating PI3K-AKT pathway

Ying Feng, Buzhen Tan
Molecular and cellular biochemistry · 2020 · vol. 475(1-2) , pp. 185–194 · doi:10.1007/s11010-020-03871-y · PMID:32809092 · W3056456130
article OA: closed CC0 ⤵ 13 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-10 ⓘ

LncRNA MALAT1 inhibits apoptosis of human endometrial stromal cells by activating the PI3K-AKT pathway through the miR-126-5p/CREB1 axis.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-09 ⓘ

The study examined how lncRNA MALAT1 regulates apoptosis in human endometrial stromal cells (HESCs) via a MALAT1–miR-126-5p–CREB1 regulatory axis, focusing on the PI3K–AKT signaling pathway. Using RT-qPCR and Western blotting, plus MTT assays for viability and annexin V-FITC staining with apoptosis markers (cleaved caspase-3, Bax, and Bcl-2), the authors found that MALAT1 or CREB1 knockdown restrained proliferation and increased apoptosis, while miR-126-5p inhibition produced opposite effects; dual-luciferase reporter assays supported direct interactions, and CREB1 silencing reversed miR-126-5p inhibitor–mediated apoptosis inhibition by inactivating PI3K–AKT. The paper explicitly acknowledges limited mechanistic scope to in vitro cell models (no in vivo functional validation is described in the provided text) and uses expression/marker endpoints as readouts. This paper is centrally about endometriosis — it investigates MALAT1-miR-126-5p-CREB1 control of HESC apoptosis through PI3K–AKT signaling in the context of endometriosis pathogenesis.

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mesh:D004715

MeSH descriptors

Cyclic AMP Response Element-Binding Protein Endometriosis Endometrium MicroRNAs RNA, Long Noncoding Stromal Cells Apoptosis Apoptosis Cells, Cultured Cell Survival Cell Survival Cyclic AMP Response Element-Binding Protein Cyclic AMP Response Element-Binding Protein Endometriosis Endometriosis Endometriosis Endometrium Endometrium Female Humans

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