Tian Y

Deep infiltrating endometriosis (DIE) and focal adenomyosis of the outer myometrium (FAOM) are closely related chronic inflammatory conditions that often coexist. The systemic immune-inflammation index (SII), systemic inflammation response …

Bisphenol A (BPA), an endocrine-disrupting chemical frequently detected in follicular fluid (FF), has been implicated in ovarian reserve dysfunction. However, data on the presence of its structural analogues within ovarian follicles remain …

OBJECTIVE: To systematically evaluate the efficacy and safety of blood-invigorating and stasis-resolving Chinese herbal medicines (BISMs) when combined with conventional clinical therapy for endometriosis, and to provide evidence-based guid…

BackgroundHerlyn-Werner-Wunderlich syndrome (HWWS) management typically requires hymenotomy. We describe the fully endoscopic, hymen-sparing septotomy in a patient with no history of sexual intercourse.Case presentationA 20-year-old patient…

Impaired fertility in obese women is closely associated with disruptions in follicular microenvironment homeostasis. However, the underlying metabolic signatures remain poorly characterized. In this study, we employed a high-fat diet induce…

With women aged ≥50 years projected to reach 1.65 billion by 2050, gynecological and breast cancers impose an escalating postmenopausal burden. Whether menopausal timing independently influences cancer risk remains uncertain. We integrated …

ObjectiveThe research focuses on understanding how GSDMD and Caspase-1, key regulators of pyroptosis, influence postoperative recurrence in Endometrial Polyps (EPs) and examines whether a combined biomarker can effectively predict recurrenc…

Adenomyosis (ADM) is a benign condition associated with various gynecological disorders. However, effective treatment options are limited, highlighting the urgent need for novel therapeutic targets. This study identified abnormal activation…

Clinical application of mesenchymal stem cells for endometrial repair has been hampered by variability in cell quality, large-scale production, and uncertainty regarding the optimal delivery route. In this study, we investigated the therape…

Neuroendocrine neoplasms (NENs) are a rare type of tumor originating from peptidergic neurons and neuroendocrine cells, which exhibit neuroendocrine differentiation and neuroendocrine marker expression. NENs can occur in any part of the bod…

BACKGROUND: This study investigates how clinical factors and hormonal levels affect oocyte retrieval in modified natural cycles, aiming to improve understanding and enhance treatment protocols. METHODS: A retrospective analysis of data fro…

Endometriosis (EMs) is an estrogen-dependent chronic inflammatory disease. While apoptosis resistance (evidenced by Bcl-2 upregulation and Bax/caspase-3 downregulation) remains a hallmark of EMs, recent studies reveal a paradoxical coexiste…

Reactive oxygen species (ROS) involve in oocyte postovulatory aging, yet the mechanism of ROS accumulation is not fully understood. We explored iron metabolic status and its relationship with ROS in mouse oocytes during postovulatory aging …

Molecular classification has emerged as a critical tool for guiding personalized treatment in endometrial cancer (EC) and atypical endometrial hyperplasia (AEH). This retrospective study aimed to assess the impact of molecular classificatio…

Endometriosis is a common gynecological disorder that is associated with chronic pelvic pain, infertility, and metabolic complications. Sarcopenia, characterized by progressive skeletal muscle loss, predominantly affects older adults. This …

BackgroundIntrauterine adhesions (IUAs) is a gynecological condition with a poor therapeutic prognosis, that severely threatens the fertility and the reproductive physiology and psychological health of women. Our previous research on the us…

BACKGROUND: Intrauterine device (IUD) migration leading to vesicouterine fistula (VUF) with vesical calculi is rare. This case is notable due to the absence of typical Youssef’s syndrome symptoms and the insidious presentation of a Type III…

BackgroundCancer-derived exosomes contribute significantly in intracellular communication, particularly during tumorigenesis. Here, we aimed to identify two immune-related ovarian cancer-derived exosomes (IOCEs) subgroups in ovarian cancer …

Herlyn-Werner-Wunderlich syndrome (HWWS) is a rare congenital genitourinary abnormality defined by uterine didelphys, obstructed hemivagina, and ipsilateral urological anomalies. Accurate diagnosis and prompt commencement of therapy can be …

Abnormal uterine bleeding (AUB) during the menopausal transition results in reproductive endocrine disorders and both physiological and pathological changes, substantially impacting women's health. This study aimed to investigate the factor…

Endometriosis is a disease characterized by the ectopic growth of endometrial tissue (glands and stroma) outside the confines of the uterus and often involves vital organs such as the intestines and urinary system. Endometriosis is consider…

BackgroundSevere acute pancreatitis (SAP) can be fatal if left unrecognized and untreated. The purpose was to develop a machine learning (ML) model for predicting the 30-day all-cause mortality risk in SAP patients and to explain the most i…

BackgroundPolycystic ovary syndrome (PCOS) is the main cause of anovulatory infertility in women of reproductive age, and low-grade chronic inflammation plays a key role in the occurrence and development of PCOS. However, obesity, as a like…

Accumulating oxidative damage is a primary driver of ovarian reserve decline along with aging. However, the mechanism behind the imbalance in reactive oxygen species (ROS) is not yet fully understood. Here we investigated changes in iron me…

BackgroundNeuroendocrine carcinoma (NEC) originating from the endometrium is rare, and there is limited knowledge regarding its diagnosis and optimal management. In this study, we present our experience with 11 patients with endometrial NEC…