MiR-518c-3p alleviates endometriosis by inhibiting ectopic endometrial migration and epithelial–mesenchymal transition via targeting ZNF608

Bin Lü, Bin Lu, Xiaohui Cao, Xinhua chen, Yan yue, Shiqing Tang, Shi-Qing Tang, Fei Xia
Archives of gynecology and obstetrics · 2022 · vol. 307(1) , pp. 205–213 · doi:10.1007/s00404-022-06439-x · PMID:35275273 · W4220665126
article OA: closed CC0 ⤵ 1 in-corpus citation
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-09 ⓘ

MiR-518c-3p inhibits endometriosis progression by targeting ZNF608, reducing ectopic endometrial cell migration, proliferation, and epithelial-mesenchymal transition.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 ⓘ

This study investigated how miR-518c-3p regulates progression of endometriosis, combining bioinformatics prediction with validation in normal and ectopic endometrium, and functional assays in endometrial stromal cells. The authors report that miR-518c-3p is downregulated in ectopic endometrium, and that transfecting miR-518c-3p mimics suppresses migration, invasion, and proliferation while promoting apoptosis; they further identify ZNF608 as a direct miR-518c-3p target via luciferase reporter assay. In a rat endometriosis-like model, overexpression of miR-518c-3p reduced ectopic endometrial cyst size and increased apoptosis, whereas co-expression of ZNF608 reversed these effects, with ZNF608 overexpression associated with higher cyst weight/volume and decreased apoptosis. The paper does not explicitly state limitations in the provided text, but the key caveat is that mechanistic and in vivo outcomes are demonstrated using cell and rat models rather than human intervention. This paper is centrally about endometriosis — it shows that miR-518c-3p alleviates endometriosis-like lesions by targeting ZNF608 to inhibit ectopic migration and EMT.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis MicroRNAs MicroRNAs MicroRNAs MicroRNAs Animals Animals Cell Movement Cell Movement Cell Proliferation Cell Proliferation Cell Proliferation Endometrium Endometrium Endometrium Epithelial-Mesenchymal Transition Epithelial-Mesenchymal Transition Epithelial-Mesenchymal Transition

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