miR-45la Inhibition Reduces Established Endometriosis Lesions in Mice

Menghui Li, Yuping Zhou, Hugh S. Taylor
Reproductive sciences (Thousand Oaks, Calif.) · 2019 · vol. 26(11) , pp. 1506–1511 · doi:10.1177/1933719119862050 · PMID:31354069 · W2965538705
article OA: closed CC0 ⤵ 13 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-06 ⓘ

Inhibition of miR-451a in mice reduced established endometriosis lesion size and altered expression of genes including YWHAZ, CAB39, MAPKI, β-catenin, and IL-6.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-06 ⓘ

This study tested whether inhibiting microRNA-451a could reduce established endometriosis in a murine model, using a miR-451a inhibitor versus a scrambled microRNA control. Treatment with the miR-451a inhibitor significantly reduced endometriosis lesion size (13 mm3 vs 30 mm3) but did not change the number of visible lesions, and it altered expression of genes including YWHAZ, CAB39, MAPKI, β-catenin, and IL-6. The paper is based on systemic inhibitor delivery in mice and does not report lesion-related functional outcomes beyond size/visible lesion counts. This paper is centrally about endometriosis — it evaluates systemic miR-451a inhibition to reduce established endometriotic lesion size in mice.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis MicroRNAs MicroRNAs Animals Endometriosis Endometriosis Female Mice Mice, Inbred C57BL MicroRNAs MicroRNAs MicroRNAs MicroRNAs

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