The Role of miRNA in Endometriosis-Related Infertility—An Update

Hanna Surmann, Ludwig Kiesel
International journal of molecular sciences · 2025 · vol. 26(12) , pp. 5862 · doi:10.3390/ijms26125862 · PMID:40565325 · W4411456930
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This review explores how dysregulated microRNAs contribute to endometriosis pathophysiology and infertility by affecting cell proliferation, migration, and progesterone resistance, and discusses their potential as diagnostic biomarkers and therapeutic targets.

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Abstract

Endometriosis, affecting up to 10% of women in their reproductive years, is a chronic and multifactorial disease characterized by the presence of endometrial tissue outside the uterus. Traditionally associated with pain and infertility, recent studies highlight its systemic nature, implicating inflammatory, immunological, and hormonal dysregulation in its pathogenesis. This paper explores the emerging role of microRNAs (miRNAs) in the pathophysiology of endometriosis and its related infertility. Evidence suggests that dysregulation of specific miRNAs influences cellular proliferation, migration, and progesterone resistance, thereby contributing to the development and progression of endometriotic lesions. Additionally, altered miRNA expression profiles hold promise as non-invasive biomarkers for improving diagnostic accuracy and as potential targets for novel therapeutic interventions. Although current diagnostic methods, such as laparoscopy, remain the gold standard, the integration of miRNA-based approaches could reduce reliance on invasive procedures and enhance treatment outcomes. Ultimately, further research-particularly regarding the interplay between endometriosis and infertility-is crucial to fully elucidate these complex mechanisms and foster the development of more effective diagnostic and therapeutic strategies.

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Condition tags

mesh:D004715endometriosisinfertility

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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