Endometriosis and migraine headache risk: a meta-analysis

Ensiyeh Jenabi, Salman Khazaei
Women & health · 2020 · vol. 60(8) , pp. 939–945 · doi:10.1080/03630242.2020.1779905 · PMID:32552576 · W3036728904
review OA: closed CC0 ⤵ 21 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This meta-analysis of 287,174 participants found a significant association between endometriosis and an increased risk of migraine headache.

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Abstract

There is high prevalence of both migraine and endometriosis; however, the association between both is controversial. This systematic review evaluated the association between endometriosis and the risk of migraine headache. A search was done of the following international electronic bibliographic databases including: PubMed, Web of Science, and Scopus to May 2020. Heterogeneity among studies was determined by Q-test and I2 statistic. Publication bias was assessed by Begg’s and Egger’s tests. The results were reported using the odds ratio (OR) estimate with its 95% confidence interval (CI) using a random-effects model. The search identified 802 articles with 287,174 participants. There was a significant association between endometriosis and the risk of migraine headache (OR = 1.56; 95% CI: 1.21, 1.90). Based on the Newcastle Ottawa Statement Manual (NOS) scale, all studies had high quality. The findings showed that endometriosis was significantly associated with an increased risk of migraine headache. Future research should be focused on measures that could help to reduce the risk of migraine headache among women with endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Migraine Disorders Endometriosis Female Humans Migraine Disorders

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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Cited by (21)

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