Gynaecologic and Systemic Comorbidities in Patients with Endometriosis: Impact on Quality of Life and Global Health

Tommaso Capezzuoli, Gretha Orlandi, Sara Clemenza, Ilaria Ponziani, Flavia Sorbi, Silvia Vannuccini, Felice Petraglia
In: Clinical and Experimental Obstetrics & Gynecology · 2022 · vol. 49(7) · doi:10.31083/j.ceog4907157 · W4285496896
article OA: gold CC0 ⤵ 8 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Endometriosis is strongly associated with gynecologic and systemic comorbidities that significantly impair women's quality of life and global health.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This narrative review assessed, using a literature search of PubMed, Cochrane Library, Scopus, and Web of Science (through December 31, 2021), which gynecologic and systemic comorbidities occur in women with endometriosis and how they affect quality of life and global health, drawing on clinical studies, systematic reviews, and meta-analyses. Across the included literature, endometriosis was reported to be strongly associated with gynecologic comorbidities such as adenomyosis, uterine fibroids, and PCOS, and with systemic conditions including autoimmune, inflammatory, psychiatric, and neurological disorders, with an overall impact on everyday function and work due to overlapping symptoms like pelvic pain and abnormal uterine bleeding; the review’s key limitation is that no inclusion/exclusion criteria beyond language and study type were used and the approach is narrative rather than fully systematic. The paper also discusses variability in reported coexistence rates of adenomyosis and endometriosis (e.g., 21.2% to 89.4%) by imaging modality and phenotype, and describes worse quality of life when adenomyosis co-occurs with deep infiltrating endometriosis. This paper is centrally about endometriosis — it synthesizes evidence on comorbid gynecologic and systemic conditions (including adenomyosis) and their effects on quality of life and global health.

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Abstract

Objectives: Endometriosis is an inflammatory disease characterized by a frequent association with gynecologic and systemic comorbidities. Our aim was to evaluate which gynecologic and systemic comorbidities occur in women affected by endometriosis and their impact on quality of life and global health. Mechanism: A literature search of the PubMed, Cochrane Library, Scopus and Web of Science databases was performed to identify the relevant studies published before December 31, 2021. We selected clinical studies, systematic reviews, and meta-analyses in English. Findings in Brief: Endometriosis is strongly associated with gynecologic (adenomyosis, uterine fibroids, polycystic ovarian syndrome-PCOS) and systemic (autoimmune, inflammatory, psychiatric and neurological disorders) comorbidities that impair women quality of life and global health through multiple mechanisms, influencing everyday life and work activities. Conclusions: Endometriosis is a chronic disease, impairing multiple functioning areas and affecting women’s health and everyday life. Considering the co-existence of multiple both gynecological and non-gynecological disorders, endometrisois needs a multidisciplinary approach. Thus, specialized referral centres are warranted for a personalized management, focused on patient symptoms and comorbidities.

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Condition tags

endometriosisadenomyosis

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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