Exploring Biopsychosocial Health Outcomes in Endometriosis and Endometriosis with Co-occurring Irritable Bowel Syndrome – A Prospective Cohort Study

Exploring Biopsychosocial Health Outcomes in Endometriosis and Endometriosis with Co-occurring Irritable Bowel Syndrome – A Prospective Cohort Study | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Exploring Biopsychosocial Health Outcomes in Endometriosis and Endometriosis with Co-occurring Irritable Bowel Syndrome – A Prospective Cohort Study Suiyin Cheah, David Skvarc, Subhadra Evans, Leesa Van Niekerk, and 1 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4505378/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Endometriosis and irritable bowel syndrome (IBS) share common pathophysiological and risk factors, often leading to misdiagnosis, diagnostic delays, and treatment implications. Further, both conditions are associated with biopsychosocial comorbidities, resulting in compromised wellbeing and reduced health-related quality of life (HRQoL). This longitudinal prospective study consisting of 610 adult women with endometriosis (EndoOnly; n = 352), and with endometriosis and co-occurring IBS-type symptoms (Endo + IBS; n = 258) aimed to investigate the differences in biopsychosocial factors, specifically HRQoL, psychological distress, pain, fatigue and menstrual symptoms over a three-year period. Using linear mixed models, results demonstrated that individuals with Endo + IBS were more likely to experience lower HRQoL and higher functional pain disability, fatigue, and menstrual symptoms compared to individuals with EndoOnly over three years. Results showed significant linear declines in rumination, total pain catastrophising, pain severity and helplessness for both groups; however, the rate of change for the Endo + IBS group tended to diminish and change direction over time. Further individuals with Endo + IBS were inclined to exhibit more complex change trajectories in psychological distress, magnification, and fatigue over time, with a trend towards worse outcomes overall. The onset of the COVID-19 during the study appeared to produce unexpected and inconsistent patterns of change for both groups. Findings highlight important implications for the implementation of multidisciplinary psychosocial healthcare, to help improve diagnosis, clinical management and overall health outcomes for individuals living with endometriosis and co-occurring IBS-type symptoms. Biological sciences/Psychology Health sciences/Gastroenterology/Gastrointestinal diseases/Functional gastrointestinal disorders Health sciences/Health care/Quality of life Health sciences/Health care/Health policy Health sciences/Risk factors Health sciences/Signs and symptoms/Comorbidities Health sciences/Signs and symptoms/Digestive signs and symptoms Health sciences/Signs and symptoms/Pain Health sciences/Signs and symptoms/Reproductive signs and symptoms Health sciences/Diseases/Reproductive disorders endometriosis irritable bowel syndrome comorbid pain quality of life COVID-19 Figures Figure 1 Figure 2 Figure 3 Introduction Endometriosis is a debilitating, inflammatory, and chronic condition where endometrial-like tissue grows outside of the uterus [ 1 , 2 ]. It affects approximately 10% of all reproductive-aged women and individuals assigned female at birth [ 3 ]. Comorbidities are commonly reported [ 4 – 6 ], and significant associations with gynaecological conditions, chronic diseases [ 7 , 8 ], pain conditions [ 9 , 10 ], and psychological disorders [ 11 , 12 ], have been found. Gastrointestinal symptoms are highly prevalent among individuals with endometriosis [ 13 , 14 ], with up to 90% reporting gastrointestinal complaints [ 15 , 16 ]. Varied symptom profiles, with common comorbidities make diagnosis and treatment difficult [ 17 ], compromising daily functioning and health-related quality of life (HRQoL; [ 13 , 18 , 19 ]. Irritable bowel syndrome (IBS) is a common, chronic disorder of the gut-brain interaction, with similar prevalence and symptomology to endometriosis [ 20 , 21 ]. It is closely associated with pelvic pain, psychological disorders, and fatigue, which negatively impact functioning and overall wellbeing [ 22 – 25 ]. Associations between endometriosis and IBS have been increasingly noted [ 13 , 26 , 27 ], and common pathophysiological mechanisms, including chronic inflammation, alterations in pain processing and the gut-brain axis, mast cell activation and altered immune function have been proposed [ 13 , 14 , 28 – 30 ]. Overlapping symptoms of the two conditions often results in repeated medical testing, misdiagnosis, and diagnostic delays, leading to increased healthcare utilisation [ 31 ], treatment complications and prolonged suffering and pain [ 13 , 32 ]. Diagnostic challenges are further compounded by the lack of established biomarkers and non-invasive diagnostics tests for both conditions [ 33 ]. Moreover, both endometriosis and IBS are associated with reduced psychological health [ 25 , 34 ], increased pain and pain catastrophising [ 35 – 37 ], impaired social and intimate relationships [ 38 , 39 ] and greater fatigue [ 23 , 40 ], adversely influencing daily functioning and overall quality of life (QoL; [ 18 , 22 ] ). Given both conditions are highly prevalent, chronic, and multifactorial, obtaining further insights into their relationship and the associated biopsychosocial influences may help to improve health provider awareness, optimise disease management, and facilitate personalised, interdisciplinary treatment and care. Although endometriosis and IBS are associated with poorer health outcomes, little is known about the compounding effect of endometriosis with co-occurring IBS-type symptoms on individual wellbeing and HRQoL. Furthermore, prospective studies exploring the effects of comorbidities on physical and psychosocial health outcomes for individuals living with endometriosis are scarce. Accordingly, this study aimed to investigate the longitudinal changes and differences in biopsychosocial factors (HRQoL, psychological distress, pain (severity, interference and catastrophising), fatigue, and menstrual symptoms) in individuals with endometriosis, with and without co-occurring IBS-type symptoms, over time. It was hypothesised that individuals with endometriosis and co-occurring IBS-type symptoms would report poorer biopsychosocial outcomes compared with individuals with endometriosis alone at baseline. It was also hypothesised that individuals with endometriosis and co-occurring IBS-type symptoms would report poorer biopsychosocial outcomes compared to individuals with endometriosis alone over three years. Materials and Methods Participants This longitudinal prospective cohort study was nested within a larger community population study examining the physical and psychosocial impact of pelvic pain on Australian women [41]. A convenience sample of Australian women aged 18-50 years, who had experienced a period in the last 12 months, completed online surveys on three occasions: baseline (T1), 12 months (T2) and 24 months (T3) between 2019 and 2021. Participants were recruited via social media platforms, women’s gyms, and university forum sites (see: [41]). The sample for this study was restricted to women with endometriosis (EndoOnly) and women with endometriosis and co-occurring IBS-type symptoms (Endo+IBS). Eligibility criteria for each group was determined by self-reported clinical diagnosis (e.g., laparoscopy, medical ultrasound for endometriosis; satisfaction of Rome IV diagnostic criteria for IBS), as well as self-reported illness (i.e., a ‘yes’ response to the survey question: Do you have any chronic illnesses? ). Ethical Approval Ethics approval was obtained from the Deakin University Human Research Ethics Committee (HEAG-H 10_2019). The study was performed in accordance with the Declaration of Helsinki and in line with relevant guidelines and/or regulations. All participants provided informed consent prior to joining the study and were free to withdraw from the study at any time. Outcomes Measures Demographic and health-related data, including participant age, ethnicity, employment status, education level, marital status, and health-related lifestyle behaviour data (e.g., smoking and alcohol consumption) were collected at baseline. Gastrointestinal symptom data were collected at baseline using the relevant section of the Rome IV diagnostic questionnaire [42]. Participants were categorised based on the presence or absence of Rome IV-defined IBS, in accordance with the questionnaire criteria. Health-Related Quality of Life HRQoL was measured using the 26-item World Health Organisation Quality of Life Assessment (WHOQOL-BREF; [43]), a self-administered questionnaire assessing four HRQoL domains: psychological health, physical health, social relationships, and environmental health. Each individual item is scored on a five-point ordinal scale from 1 to 5, with higher scores indicating higher HRQoL. The WHOQOL-BREF has shown good internal consistency(α > 0.90; [43,44]) Psychological Distress Psychological distress was evaluated using the 21-item Depression Anxiety and Stress Scale (DASS-21; [45,46]), a self-report measure assessing symptoms of anxiety, depression, and stress. Each subscale is used as an indicator of emotional distress, and consists of seven items, rated on a four-point scale from 0 to 3, with higher scores indicating greater levels of psychological distress. The DASS-21 has shown good internal consistency (α = 0.92; [45]) Pain Severity Menstrual pain severity was measured with a single item numeric rating scale (NRS; [47] to rate ‘ what is your usual level of endometriosis pain (without pain medicine) ?’. Scores ranged from 0 (no pain) to 10 (worst pain possible) and were categorised as: mild pain (scores 1-4), moderate pain (scores 5–7), or severe pain (scores 8–10), consistent with previous approaches [48,49]. The NRS has demonstrated acceptable validity in individuals with menstrual pain [47]. Functional Pain Disability Functional pain disability was measured using one subscale of the Brief Pain Inventory (BPI; [50]), to assess pain interference experienced in the past 24 hours, using an 11-point scale (where 0 = does not interfere, and 10 = completely interferes). The sub-scale comprises of seven pain interference items evaluating different domains including general activity, relations with others and enjoyment of life, with higher scores indicating increased functional pain impairment. The BPI has shown acceptable internal consistency in both pain and non-pain populations (α = 0.70 to 0.88; [51,52]). Pain Catastrophising Pain catastrophising was measured using the 13-item Pain Catastrophizing Scale (PCS; [53], which assesses pain-related magnification, rumination, helplessness and total pain catastrophising. The measure uses a 5-point Likert scale to produce a total score (0–52), with higher scores indicating higher levels of pain catastrophising. A total score of 30 or more indicates a clinically significant level of catastrophizing. The PCS has shown high internal consistency, (α = .93;[53]). Fatigue Fatigue was assessed using the Fatigue Symptom Inventory (FSI; [54]), a 14-item self-report questionnaire evaluating the severity, frequency and daily pattern of fatigue and its observed interference with QoL. Items are scored using an 11-point scale. This study calculated a total disruption index score by summing items 5-11. The FSI has shown good validity and reliability (α = 0.84 to 0.96;[54]). Menstrual Symptoms A validated numerical rating scale [47] was used to assess the perceived severity of nine common menstrual symptoms (e.g., abdominal cramps, lower back pain) experienced over the past six months. The measure uses a scale ranging from 0 (not present) to 10 (extremely severe), with higher scores indicating an increased presence of dysmenorrhea symptoms. Covariates Age (in years), contraceptive pill usage, age of menarche (in years) and body mass index (BMI) were included as covariates due to their association with endometriosis, IBS, and the outcome variables of interest. Data Analysis Data from the original study were collected using Qualtrics. All statistical analyses were performed using Jamovi software (The Jamovi Project, 2021) and the GAMlj package (version 3.0). Baseline group comparisons of continuous variables were assessed using ANOVA, and chi-squared tests were used for categorical variable comparisons. Little’s MCAR test was undertaken to examine if data were missing at random. Restricted maximum likelihood linear mixed models (LMM) were used to investigate differences in outcome variables between the groups (EndoOnly, Endo+IBS) over time. LMM analyses were selected for their ability to manage multiple observations and handle missing data without compromising power [55,56]. Each model included random intercepts for participant clusters, and was adjusted for age, contraceptive pill usage, age of menarche, and BMI. Outcome data was visually inspected using histograms to check the distribution of the residuals. No transformations were required. To analyse potential trends in the means of the groups, polynomial contrast estimates were fit for time (linear, quadratic) and post hoc comparisons. Simple effects of time analyses were undertaken for all models. Given the study's exploratory nature, we continued with our analysis and interpretation of the data, even when the omnibus main effects or interaction effects were statistically insignificant, and no adjustments for multiple comparisons were made. Due to the large number of outcome measures, only statistically significant or clinically relevant results have been reported. A comprehensive summary of findings is available in the Supplementary Information File (SI1 – SI5). Results Study Population At baseline, 610 participants were included in the study. From the original sample of 2,426 we excluded participants who did not report a diagnosis of endometriosis or IBS, nor symptoms characteristic of either condition ( N = 1,854). Of the 610 included participants, 352 (57.7%) constituted the EndoOnly group and 258 (42.3%) the Endo+IBS group. Participant Characteristics Participant characteristics by group at baseline are provided in Table 1 . No significant differences between the EndoOnly and Endo+IBS groups were observed for any demographic or health-related characteristics. All participants were female and resided in Australia. Most participants were employed (76.4%) and tertiary educated (78.9%). Participants identified as Anglo ( n = 512; 83.9%), European ( n = 143; 23.4%), Chinese ( n = 3; 0.5%), Indian ( n = 9; 1.5%) or Other Asian ( n = 27; 4.4%) ethnic groups. Table 1 - Participants' descriptive statistics at baseline and test of differences between EndoOnly and Endo+IBS Total (N = 610) Endo Only (n = 352) Endo+IBS (n = 258) Test of differences Age - years ( M, SDs ) 29.92 7.55 30.16 6.57 F (1, 584) = 0.18, p = 0.676 Sex (%, number) χ² (1) = 0.00, p = 1.000 Female 100% 352 100% 258 Male 0% 0 0% 0 Education (%, number) χ² (6) = 7.75, p = 0.257 Less that year 12 4.0 % 14 3.9 % 10 Year 12 or equivalent 17.0 % 60 20.5 % 53 Vocational education (TAFE) 22.2 % 78 28.3 % 73 Bachelor’s degree 36.6 % 129 31.4 % 81 Master’s degree 11.9 % 42 7.4 % 19 PhD / doctorate 1.1 % 4 1.6 % 4 Other (please specify) 7.1 % 25 7.0 % 18 Marital Status (%, number) χ² (5) = 4.21, p = 0.520 Single (never married) 36.9 % 130 37.6 % 97 Married / de facto 56.3 % 198 56.6 % 146 Widowed 0.0 % 0 0.4 % 1 Divorced 3.7 % 13 3.1 % 8 Separated 2.3 % 8 0.8 % 2 Other (please specify) 0.9 % 3 1.6 % 4 Employment Status (%, number) χ² (8) = 14.7, p = 0.065 Employed full time 48.0 % 169 45.7 % 118 Employed part time 23.3 % 82 23.3 % 60 Unemployed currently looking for work 1.1 % 4 3.9 % 10 Unemployed not currently looking for work 1.1 % 4 0.8 % 2 Student 12.5 % 44 7.8 % 20 Homemaker 2.3 % 8 4.7 % 12 Self-employed 5.1 % 18 3.5 % 9 Unable to work 2.8 % 10 4.3 % 11 Other (please specify) 3.7 % 13 6.2 % 16 Aboriginal or Torres Strait Islander (%, number) χ² (1) = 1.34, p = 0.248 Yes 2.3 % 8 3.9 % 10 No 97.7 % 344 96.1 % 248 Children (%, number) χ² (1) = 0.14, p = 0.706 Yes 28.1 % 99 26.7 % 69 No 71.9 % 253 73.3 % 189 Age of Menarche ( M, SDs ) 12.49 1.67 12.50 1.70 F (1, 608) = 1.72e-04, p = 0.99 Contraceptive Pill Usage (%, number) χ² (1) = 0.42, p = 0.516 Yes 34.7 % 122 37.2 % 96 No 65.3 % 230 62.8 % 162 Smoking (%, number) χ² (2) = 1.19, p = 0.551 Current smoker 7.4 % 26 9.7 % 25 Former smoker 17.9 % 63 16.3 % 42 Never smoked 74.7 % 263 73.9 % 190 Alcohol (%, number) χ² (4) = 2.15, p = 0.708 More than 2 standard drinks per day 0.6 % 2 1.6 % 4 Fewer than 2 standard drinks per day 2.0 % 7 2.3 % 6 I drink several times a week 9.9 % 35 8.1 % 21 I occasionally drink 70.5 % 248 71.7 % 185 I never drink 17.0 % 60 16.3 % 42 BMI ( M, SDs ) 28.11 6.77 27.17 6.03 F (1, 333) = 1.73, p = 0.189 Descriptive statistics were reported as mean ± standard deviation and percentages. M = mean, SD = standard deviation, p = test of significance, two-tailed with a threshold of < 0.05, χ² = test of difference (categorical variables), F = ratio of two variances (independent samples) Outcome Variables Table 2 presents each outcome variable's means and standard deviations according to time and group. At baseline, findings showed that the Endo+IBS group reported worse outcomes compared with the EndoOnly group on HRQoL: physical ( p = 0.011), psychological ( p = 0.004) and social ( p = 0.013), psychological distress: depression ( p = 0.029), anxiety ( p =0.017) and overall distress ( p = 0.022), functional pain disability ( p = 0.024), and menstrual symptoms ( p = < .001). Notably, clinically relevant levels of pain catastrophizing were observed at baseline for both the EndoOnly ( M = 30.25, SD = 11.61) and Endo+IBS ( M = 31.04, SD = 11.23) groups. Results from Little’s MCAR test (>.05) and visual pattern inspection suggested that missing data at T3 were missing completely at random. Table 2 - Descriptive statistics for outcome variables over time by group (EndoOnly,Endo+IBS) Time 1 Time 2 Time 3 Mean SD N Mean SD N Mean SD N EndoOnly Physical health (WQoL-Ph) 51.55 16.86 345 55.20 20.01 98 53.22 18.16 63 Psychological health (WQoL-Ps) 50.81 16.39 345 51.95 18.13 98 51.52 16.32 63 Social relationships (WQoL-SR) 55.97 21.64 345 58.92 21.19 98 58.25 17.35 63 Environmental health (WQoL-E) 66.74 15.95 346 70.61 16.30 98 70.38 15.43 63 Stress (DASS-S) 18.55 9.39 350 17.65 10.88 102 18.31 10.34 59 Depression (DASS-S) 13.16 10.53 350 12.65 11.05 102 12.71 9.89 59 Anxiety (DASS-A) 10.77 9.01 350 9.82 9.02 102 10.03 7.95 59 Total distress (DASS-T) 42.48 25.77 350 40.12 27.84 102 41.05 24.61 59 Pain severity (NSR) 7.70 1.72 352 6.99 1.98 107 6.89 1.82 66 Functional pain disability (BPI) 4.29 2.49 345 3.80 2.74 96 3.80 2.74 59 Helplessness (PCS-H) 13.65 5.79 352 11.55 5.88 103 8.88 6.09 59 Magnification (PCS-M) 5.91 3.05 351 4.84 3.29 103 4.46 3.42 59 Rumination (PCS-M) 10.70 4.22 350 8.03 4.29 103 6.31 4.25 59 Total pain catastrophising (PCS-T) 30.25 11.61 350 24.43 12.46 103 19.64 12.60 59 Fatigue (FSI) 34.99 15.88 347 25.31 16.65 89 32.53 16.43 59 Menstrual symptoms (MSS) 50.10 15.14 346 50.50 18.68 105 48.24 17.68 66 Endo+IBS Physical health (WQoL-Ph) 47.82 18.88 256 50.42 18.30 76 48.00 19.35 52 Psychological health (WQoL-Ps) 46.67 18.43 256 48.79 20.16 76 47.79 18.83 52 Social relationships (WQoL-SR) 51.20 24.10 256 49.16 20.84 76 54.21 23.27 52 Environmental health (WQoL-E) 64.21 17.96 256 66.09 14.12 76 65.96 19.42 52 Stress (DASS-S) 19.66 9.98 257 16.38 9.09 78 17.92 8.91 50 Depression (DASS-S) 15.12 11.37 256 13.38 11.25 78 14.64 10.73 50 Anxiety (DASS-A) 12.58 9.37 257 8.92 7.89 78 11.04 9.19 50 Total distress (DASS-T) 47.44 26.73 256 38.69 24.30 78 43.60 24.33 50 Pain severity (NSR) 7.85 1.49 258 7.33 1.72 81 6.98 1.63 52 Functional pain disability (BPI) 4.76 2.50 256 4.21 2.77 75 4.66 2.83 45 Helplessness (PCS-H) 13.75 5.42 256 11.40 4.96 80 9.27 5.67 48 Magnification (PCS-M) 6.19 3.14 256 5.33 2.80 80 5.08 3.38 48 Rumination (PCS-M) 11.09 3.88 256 8.13 3.81 80 7.88 4.50 48 Total pain catastrophising (PCS-T) 31.04 11.23 256 24.85 10.23 80 22.23 12.54 48 Fatigue (FSI) 36.71 16.28 257 27.99 14.92 72 36.31 16.41 49 Menstrual Symptoms (MSS) 55.51 13.14 257 54.58 13.07 81 51.33 15.36 52 M = mean, SD = standard deviation, N = number of participants Main Analysis No significant main effects, interactions, or simple effects for environmental HRQoL was observed. The omnibus and parameter estimates for the included covariates demonstrated significant associations between age and all outcomes, except for social HRQoL ( p = 0.946), and environmental HRQoL ( p =0.191) with older participants reporting better outcomes than younger participants. Higher BMI was significantly associated with lower physical ( B = -0.52, t = -3.57, p < .001), psychological ( B = -0.46, t = -3.34, p < .001), and environmental ( B = -0.43, t = -3.10, p = .002) HRQoL. Contraceptive pill usage and age of menarche were not significantly associated with any outcome variable. Table 3 presents the omnibus tests fixed effects for group, time, and group*time interactions (covariates not reported) for each outcome. Table 4 contains the parameter estimates for the same. A significant quadratic group*time interaction for rumination was found, suggesting that changes in rumination scores over time significantly differed depending on group membership (EndoOnly or Endo+IBS). Examination of the parameter estimates also revealed small to moderate significant quadratic group*time interactions for total pain catastrophising and social HRQoL. No other interaction effects were observed. Table 3 - Fixed Effect Omnibus for Group, Time, and Group*Time (Excluding Covariates) Group Time Group*Time R 2 M R 2 C F Num df Den df p F Num df Den df p F Num df Den df p Physical health (WQoL-Ph) 0.08 0.59 4.92 1 424 0.027 1.91 2 225 0.151 0.13 2 225 0.882 Psychological health (WQoL-Ps) 0.07 0.61 5.59 1 422 0.019 1.29 2 213 0.276 0.83 2 212 0.439 Social relationships (WQoL-SR) 0.03 0.53 5.48 1 417 0.02 0.42 2 223 0.657 2.76 2 223 0.066 Environmental health (WQoL-E) 0.04 0.73 2.38 1 422 0.124 0.03 2 191 0.966 0.34 2 191 0.712 Depression (DASS-S) 0.07 0.65 3.48 1 427 0.063 4.58 2 197 0.011 0.32 2 197 0.727 Anxiety (DASS-A) 0.10 0.65 1.45 1 430 0.229 6.47 2 205 0.002 1.96 2 205 0.144 Stress (DASS-S) 0.08 0.55 0.00 1 422 0.960 6.40 2 220 0.002 0.45 2 220 0.636 Total distress (DASS-T) 0.10 0.64 1.62 1 426 0.203 7.41 2 200 < .001 0.77 2 200 0.463 Pain severity (NRS) 0.08 0.53 0.32 1 420 0.573 19.97 2 253 < .001 0.56 2 253 0.571 Functional pain disability (BPI) 0.05 0.46 3.90 1 417 0.049 2.18 2 234 0.115 0.08 2 233 0.923 Helplessness (PCS-H) 0.15 0.62 0.00 1 426 0.952 20.06 2 210 < .001 1.09 2 210 0.337 Magnification (PCS-M) 0.11 0.48 0.72 1 411 0.395 6.55 2 255 0.002 1.23 2 254 0.294 Rumination (PCS-R) 0.17 0.60 0.34 1 421 0.561 41.02 2 215 < .001 4.99 2 215 0.008 Total pain catastrophising (PCS-T) 0.17 0.64 0.26 1 428 0.608 28.91 2 210 < .001 2.93 2 210 0.056 Fatigue (FSI) 0.10 0.61 7.05 1 430 0.008 17.11 2 202 < .001 1.63 2 202 0.199 Menstrual Symptoms (MSS) 0.06 0.59 5.77 1 423 0.017 0.04 2 231 0.965 0.37 2 231 0.689 R 2 M = R-squared marginal estimates variance explained by the fixed effects, R 2 C = R-squared conditional estimates the fraction explained by the fixed and random effects, F = F-statistic, p = test of significance, two-tailed with a threshold of < 0.05, 95% confidence interval. Measure abbreviations: WQoL-Ph: World Health Organisation Quality of Life Assessment (WHOQOL-BREF)-physical health subscale; WQoL-Ps: WHOQOL-BREF-psychological health subscale; WQoL-SR: WHOQOL-BREF-social relationships subscale: WQoL-E: WHOQOL-BREF-environment subscale: DASS-A: Depression Anxiety and Stress Scale–anxiety subscale; DASS-D: Depression Anxiety and Stress Scale–depression subscale; DASS-S: Depression Anxiety and Stress Scale–stress subscale; DASS-T: Depression Anxiety and Stress Scale–Total; NRS: Pain Numerical Response Scale; BPI: Brief Pain Inventory PCS-H: Pain Catastrophizing Scale–helplessness subscale; PCS-M: Pain Catastrophizing Scale–magnification subscale; PCS-R: Pain Catastrophizing Scale-rumination subscale; FSI: Fatigue Symptom Inventory; MSS: Menstrual Symptom Scale. Table 4 – Parameter Estimates for Fixed Effects - Group, Time, and Group*Time (excluding covariates) WQoL-Ph WQoL-Ps WQoL-SR WQoL - E B SE t p B SE t p B SE t p B SE t p (Intercept) 51.37 1.08 47.58 < .001 48.95 1.03 47.60 < .001 54.04 1.38 39.06 < .001 66.08 1.01 65.76 < .001 Group 4.80 2.17 2.22 0.027 4.88 2.06 2.36 0.019 6.49 2.77 2.34 0.020 3.11 2.02 1.54 0.124 Time (linear) 0.43 1.23 0.35 0.726 -1.58 1.14 -1.38 0.168 1.22 1.63 0.75 0.454 -0.12 0.96 -0.12 0.902 Time (quadratic) -2.33 1.34 -1.74 0.083 -1.45 1.23 -1.18 0.24 1.27 1.77 0.72 0.471 -0.27 1.03 -0.26 0.796 Group *Time (linear) -1.01 2.46 -0.41 0.683 1.32 2.28 0.58 0.563 -3.82 3.25 -1.17 0.242 -1.47 1.91 -0.77 0.444 Group *Time (quadratic) 0.43 2.67 0.16 0.873 3.12 2.47 1.27 0.207 -8.07 3.53 -2.29 0.023 -1.03 2.06 -0.50 0.617 DASS-D DASS-A DASS-S DASS-T B SE t p B SE t p B SE t p B SE t p (Intercept) 13.23 0.63 20.95 < .001 10.43 0.51 20.46 < .001 17.43 0.59 29.76 < .001 41.13 1.51 27.28 < .001 Group -2.36 1.27 -1.86 0.063 -1.23 1.02 -1.21 0.229 0.06 1.17 0.05 0.96 -3.85 3.02 -1.27 0.203 Time (linear) 1.19 0.69 1.72 0.087 0.88 0.57 1.55 0.123 -0.03 0.70 -0.04 0.966 2.02 1.68 1.20 0.231 Time (quadratic) 2.05 0.71 2.89 0.004 2.08 0.59 3.56 < .001 2.48 0.73 3.39 < .001 6.67 1.73 3.85 < .001 Group *Time (linear) -0.79 1.38 -0.57 0.567 -0.13 1.13 -0.11 0.912 0.36 1.41 0.25 0.799 -0.74 3.36 -0.22 0.826 Group *Time (quadratic) -1.00 1.42 -0.70 0.484 -2.24 1.17 -1.92 0.057 -1.16 1.46 -0.80 0.427 -4.28 3.47 -1.23 0.219 Pain NSR BPI FSI MSS B SE t p B SE t p B SE t p B SE t p (Intercept) 7.18 0.09 76.68 < .001 4.23 0.16 26.54 < .001 32.34 0.97 33.38 < .001 52.31 0.89 58.50 < .001 Group 0.11 0.19 0.56 0.573 -0.63 0.32 -1.98 0.049 -5.16 1.94 -2.66 0.008 -4.31 1.79 -2.40 0.017 Time (linear) -0.45 0.11 -4.01 < .001 -0.11 0.21 -0.51 0.608 -0.62 1.11 -0.56 0.578 -0.15 1.01 -0.15 0.883 Time (quadratic) 0.41 0.12 3.48 < .001 0.38 0.22 1.75 0.082 6.44 1.19 5.40 < .001 0.18 1.06 0.17 0.865 Group *Time (linear) 0.09 0.23 0.39 0.699 -0.12 0.41 -0.29 0.774 -3.94 2.22 -1.78 0.077 -0.38 2.03 -0.19 0.853 Group *Time (quadratic) -0.19 0.24 -0.83 0.409 0.07 0.44 0.17 0.864 -0.51 2.39 -0.22 0.83 -1.82 2.11 -0.86 0.39 PCS-H PCS-M PCS-R PCS-T B SE t p B SE t p B SE t p B SE t p (Intercept) 11.25 0.33 33.89 < .001 5.16 0.18 28.02 < .001 8.51 0.25 34.00 < .001 24.91 0.68 36.65 < .001 Group -0.04 0.67 -0.06 0.952 -0.31 0.37 -0.85 0.395 -0.29 0.50 -0.58 0.561 -0.70 1.36 -0.51 0.608 Time (linear) -2.14 0.39 -5.42 < .001 -0.41 0.24 -1.68 0.094 -2.14 0.31 -6.96 < .001 -4.67 0.80 -5.85 < .001 Time (quadratic) 0.55 0.40 1.38 0.17 0.61 0.25 2.47 0.014 1.01 0.31 3.24 0.001 2.21 0.80 2.75 0.007 Group *Time (linear) -0.59 0.79 -0.75 0.454 -0.39 0.48 -0.81 0.416 -0.61 0.61 -0.99 0.325 -1.66 1.59 -1.04 0.301 Group *Time (quadratic) -1.15 0.80 -1.45 0.149 -0.76 0.49 -1.53 0.126 -1.96 0.62 -3.16 0.002 -3.87 1.61 -2.40 0.017 B = fixed effects co-efficient, SE = standard error, t = t-test, p = test of significance, two-tailed with a threshold of < 0.05, 95% confidence interval. Measure abbreviations: WQoL-Ph: World Health Organisation Quality of Life Assessment (WHOQOL-BREF)-physical health subscale; WQoL-Ps: WHOQOL-BREF-psychological health subscale; WQoL-SR: WHOQOL-BREF-social relationships subscale: WQoL-E: WHOQOL-BREF-environment subscale: DASS-A: Depression Anxiety and Stress Scale–anxiety subscale; DASS-D: Depression Anxiety and Stress Scale–depression subscale; DASS-S: Depression Anxiety and Stress Scale–stress subscale; DASS-T: Depression Anxiety and Stress Scale–Total; NRS: Pain Numerical Response Scale; BPI: Brief Pain Inventory PCS-H: Pain Catastrophizing Scale–helplessness subscale; PCS-M: Pain Catastrophizing Scale–magnification subscale; PCS-R: Pain Catastrophizing Scale-rumination subscale; FSI: Fatigue Symptom Inventory; MSS: Menstrual Symptom Scale. Results also showed significant main effects of group membership, with higher HRQoL (physical, psychological, and social), and lower functional pain disability, fatigue, and menstrual symptoms observed for the EndoOnly group across the study period. Significant main effects of time for psychological distress (symptoms of depression, anxiety, stress, and total distress), pain severity, pain catastrophising (helplessness, magnification, rumination, and total) and fatigue were also indicated. Findings suggested that average outcome levels significantly changed over time, regardless of group allocation. Table 5 presents the simple effects of time parameter estimates for significant findings only. Despite observing a significant interaction, no simple effects of time for social HRQoL were found. Significant linear reductions in rumination, total pain catastrophising, pain severity and helplessness, were observed, with effects generally stronger for the EndoOnly group. Results also showed significant positive quadratic effects of time for pain severity in both groups, and for rumination and total pain catastrophising in the Endo+IBS group only. Findings suggested that whilst both groups showed significant reductions in outcome levels, the rates of decline were not stable and tended to diminish, flatten out or change direction over time. In particular, trend findings for rumination and total pain catastrophising indicated that whilst individuals in the EndoOnly group consistently improved linearly, the rate of change in both outcomes for the Endo+IBS group was initially fast and steep (improvement in scores), but then diminished and rebounded between T2 to T3 ( Figure 1 ). Table 5 – Simple Effects of Time Parameter Estimates for Significant Outcomes Only Group Contrast B t p DASS-D Endo+IBS linear 1.58 1.505 0.134 quadratic 2.55 2.334 0.021 Endo only linear 0.79 0.886 0.377 quadratic 1.56 1.71 0.089 DASS-A Endo+IBS linear 0.94 1.09 0.277 quadratic 3.21 3.56 < .001 Endo only linear 0.82 1.11 0.268 quadratic 0.96 1.28 0.201 DASS-S Endo+IBS linear -0.21 -0.196 0.845 quadratic 3.06 2.723 0.007 Endo only linear 0.15 0.163 0.87 quadratic 1.90 2.027 0.044 DASS-T Endo+IBS linear 2.39 0.933 0.352 quadratic 8.81 3.304 0.001 Endo only linear 1.65 0.758 0.449 quadratic 4.53 2.044 0.042 Pain NSR Endo+IBS linear -0.50 -2.83 0.005 quadratic 0.51 2.77 0.006 Endo only linear -0.41 -2.88 0.004 quadratic 0.31 2.1 0.037 FSI Endo+IBS linear 1.35 0.794 0.428 quadratic 6.69 3.662 < .001 Endo only linear -2.59 -1.815 0.071 quadratic 6.18 4.029 < .001 PCS-H Endo+IBS linear -1.84 -3.0263 0.003 quadratic 1.13 1.8473 0.066 Endo only linear -2.43 -4.8501 < .001 quadratic -0.03 -0.0544 0.957 PCS-M Endo+IBS linear -0.21 -0.562 0.574 quadratic 0.99 2.619 0.009 Endo only linear -0.61 -1.962 0.051 quadratic 0.23 0.722 0.471 PCS-R Endo+IBS linear -1.83 -3.8718 < .001 quadratic 1.99 4.1858 < .001 Endo only linear -2.44 -6.2484 < .001 quadratic 0.02 0.0615 0.951 PCS-T Endo+IBS linear -3.84 -3.119 0.002 quadratic 4.14 3.367 < .001 Endo only linear -5.49 -5.416 < .001 quadratic 0.28 0.266 0.79 B = fixed effects co-efficient, t = t-test, p = test of significance, two-tailed with a threshold of < 0.05, 95% confidence interval. Measure abbreviations: DASS-A: Depression Anxiety and Stress Scale–anxiety subscale; DASS-D: Depression Anxiety and Stress Scale–depression subscale; DASS-S: Depression Anxiety and Stress Scale–stress subscale; DASS-T: Depression Anxiety and Stress Scale–Total; NRS: Pain Numerical Response Scale; FSI: Fatigue Symptom Inventory; PCS-H: Pain Catastrophizing Scale–helplessness subscale; PCS-M: Pain Catastrophizing Scale–magnification subscale; PCS-R: Pain Catastrophizing Scale-rumination subscale; PCS-T: Pain Catastrophizing Scale-Total Trend findings for pain severity also demonstrated rebound patterns for both groups from T2 to T3. However, a slightly faster reduction in pain severity levels was observed in the Endo+IBS group compared to the EndoOnly group ( Figure 2 ). This resembled the trends observed for rumination and total pain catastrophising, whereby the EndoOnly group experienced sustained linear improvements in helplessness, whilst the Endo+IBS group showed a trend for a slight increase in helplessness at T3 ( Figure 3 ). Examination of the simple effects revealed significant positive quadratic effects for fatigue in both groups. Significant positive quadratic effects for psychological distress (depression, anxiety, stress, and distress overall) and magnification were also found for the Endo+IBS group. The observed positive quadratic effects indicated initial reductions from baseline that attenuated or reversed by T3. Examination of all significant models revealed that aside from pain severity, the Endo+IBS group reported poorer outcomes on each measure compared with the EndoOnly group at T1 and T3. Notably, across both groups, a trend for improvement in most outcome measures (except for psychological QoL and menstrual symptoms for EndoOnly and social relationships QoL for Endo+IBS) was observed at T2. The complete set of omnibus fixed effects, parameter estimates, and simple effects are available in the Supplementary Information (SI1-SI4). Post-Hoc Comparisons Post hoc comparisons within and between groups were performed for each outcome. Table 6 presents the significant post hoc comparisons for T1 and T3 only. Both the EndoOnly and Endo+IBS groups showed significantly reduced scores on measures of pain severity, helplessness, rumination, and total pain catastrophising from baseline to 24-month follow-up. Elsewhere, we observed significant improvements in fatigue for both groups from T1 to T2 (EndoOnly: MD =9.40 , t = 4.99 , p <. 001; Endo+IBS: MD =7.24, t =3.32, p =.001), however significant increases were reported from T2 to T3 (EndoOnly: MD =-5.74, t =-2.43, p =.016; Endo+IBS: MD =-9.15, t =-3.20, p =.002). Table 6 – Significant Post Hoc Comparisons Within and Between EndoOnly and Endo+IBS for T1 and T3 Group Time Group Time Difference SE t df p WQoL-Ph Endo+IBS 1 EndoOnly 1 -5.69 1.96 -2.90 395 0.004 WQoL-Ps Endo+IBS 1 EndoOnly 1 -5.22 1.87 -2.79 388 0.006 Endo+IBS 3 EndoOnly 3 -7.09 3.32 -2.13 372 0.034 WQoL-S Endo+IBS 1 EndoOnly 1 -5.90 2.51 -2.35 402 0.019 WQoL-E Endo+IBS 1 EndoOnly 1 -3.73 1.86 -2.01 364 0.046 DASS - A Endo+IBS 1 EndoOnly 1 2.06 0.92 2.23 387 0.026 Pain NSR EndoOnly 1 EndoOnly 3 0.58 0.20 2.87 249 0.004 Endo+IBS 1 Endo+IBS 3 0.70 0.25 2.82 250 0.005 PCS - H EndoOnly 1 EndoOnly 3 3.44 0.71 4.84 221 < .001 Endo+IBS 1 Endo+IBS 3 2.61 0.86 3.02 221 0.003 PCS R EndoOnly 1 EndoOnly 3 3.45 0.55 6.23 230 < .001 Endo+IBS 1 Endo+IBS 3 2.59 0.67 3.86 229 < .001 PCS-T EndoOnly 1 EndoOnly 3 7.77 1.44 5.40 218 < .001 Endo+IBS 1 Endo+IBS 3 5.43 1.74 3.11 218 0.002 FSI Endo+IBS 3 EndoOnly 3 8.15 3.21 2.54 345 0.012 MSS Endo+IBS 1 EndoOnly 1 4.78 1.64 2.91 399 0.004 SE = standard error, t = t-test, df = degrees of freedom, p = test of significance, two-tailed with a threshold of < 0.05, 95% confidence interval. Measure abbreviations: WQoL-Ph: World Health Organisation Quality of Life Assessment (WHOQOL-BREF)-physical health subscale; WQoL-Ps: WHOQOL-BREF-psychological health subscale; WQoL-SR: WHOQOL-BREF-social relationships subscale: WQoL-E: WHOQOL-BREF-environment subscale: DASS-A: Depression Anxiety and Stress Scale–anxiety subscale; DASS-D: Depression Anxiety and Stress Scale–depression subscale; DASS-S: Depression Anxiety and Stress Scale–stress subscale; DASS-T: Depression Anxiety and Stress Scale–Total; NRS: Pain Numerical Response Scale; BPI: Brief Pain Inventory PCS-H: Pain Catastrophizing Scale–helplessness subscale; PCS-M: Pain Catastrophizing Scale–magnification subscale; PCS-R: Pain Catastrophizing Scale-rumination subscale; FSI: Fatigue Symptom Inventory; MSS: Menstrual Symptom Scale Results also showed significant differences between the groups at T3, with the Endo+IBS group reporting significantly lower psychological QoL and significantly higher fatigue than the EndoOnly group. Interestingly, the Endo+IBS group demonstrated a tendency towards rebound patterns from T2 to T3, with post hoc comparisons revealing significant increases in symptoms of depression ( MD =-4.25 , t =-2.47 , p=. 014), anxiety ( MD =-4.59 , t =-3.24 , p=. 001), stress ( MD =-3.60 , t =-2.03 , p=. 043), distress overall ( MD =-12.48 , t =-2.98 , p=. 003) and fatigue ( MD =-9.15 , t =-3.20 , p=. 002) from 12-months to 24-months follow up. Conversely, we observed increases in social QoL ( MD =-8.72 , t =-2.07, p=. 04) for the Endo+IBS group over the same period. The complete set of significant post hoc comparisons at all time points is available in the Supplementary Information (SI5). Discussion This prospective longitudinal study is the first to explore and compare the changes in biopsychosocial outcomes between individuals living with endometriosis (EndoOnly) and those living with co-occurring IBS-type symptoms (Endo+IBS) over time. Our findings suggested that individuals with Endo+IBS were more likely to experience lower HRQoL and higher functional pain disability, fatigue, and menstrual symptoms compared to individuals with EndoOnly over three years. Results also indicated that individuals with EndoOnly experienced lower and more consistent decreases in levels of pain catastrophising, especially rumination; whilst for individuals with Endo+IBS, initial declines in scores appeared to diminish or regress over time. Our exploratory observations also implied that individuals with Endo+IBS tended to exhibit more complex change trajectories in pain severity, psychological distress, helplessness, magnification, and fatigue over time, with a trend towards poorer outcomes overall. Notably, the occurrence of the COVID-19 global pandemic during the study seemingly influenced the outcome trajectories amongst both groups, with inconsistent patterns of change observed across several outcome measures. Collectively, these findings provide valuable insights into the unique challenges faced by individuals living with comorbidities and the enduring impacts on health-related factors and overall QoL. The complex relationships between endometriosis and co-occurring conditions have been previously described [4,6,34], with evidence showing an increased risk of gastrointestinal disorders in endometriosis populations [15,30,57-59]. In this study, a high prevalence of IBS-type symptoms in individuals with endometriosis (42.3%) was observed, consistent with a recent meta-analysis which found prevalence rates of IBS ranging from 10.6% to 52% (pooled prevalence of 23.4%; [60]). Two factors may explain the notably high occurrence of IBS-type symptoms in our study. Firstly, the sample from the original study included individuals with self-reported dysmenorrhea, which is associated with an increased risk of co-occurring IBS [61-63], although prevalence ranges are comparative to other populations [61,64,65]. Secondly, in this study, a combination of self-reported diagnosis and the Rome IV-IBS criteria was used to classify participants, which most likely extended the scope of included IBS-type symptom cases [66]. Both individuals with endometriosis and individuals with IBS experience a greater burden of comorbidities compared with healthy populations [5,6,31,57,67]. For individuals with endometriosis, comorbidities are associated with impaired physical, psychological, and social functioning, causing detrimental disruptions to everyday life [7,35,68-70]. Our observations of significant differences at baseline and generally worse longitudinal outcomes for the Endo+IBS group are compatible with these findings and support the burden of comorbidity on individual health outcomes overall. Furthermore, a recent retrospective biobank cohort study ( N = 65, 421) revealed that individuals living with both endometriosis and IBS are more likely to suffer from multiple co-occurring conditions and experience greater abdominal and pelvic pain compared to individuals with endometriosis or IBS alone [57]. In endometriosis and IBS, disease-related pain is significantly associated with increased symptoms of depression and anxiety, pain catastrophising and fatigue [35,37,40,71-73], whilst disease severity may directly influence how individuals with IBS adaptively cope with and respond to pain [74-76]. Accordingly, the presence of comorbid IBS-type symptoms in endometriosis potentially influences individual responses to condition-related factors and may exacerbate adverse health outcomes, impairing overall HRQoL. Our findings emphasise the inherent, persistent, and compounding effect of comorbid chronic conditions on individual health and wellbeing and highlight the complexities and challenges for health management, treatment, and ongoing care [77]. Pain catastrophising is a negative cognitive-emotional response to actual or anticipated pain and a critical predictor of pain-related outcomes. It is significantly associated with compromised functioning, increased symptoms of depression and anxiety, greater pain severity and sensitivity and reduced HRQoL across endometriosis and IBS populations [36,37,78-80]. This study confirmed significant decreases in rumination and pain catastrophising for both groups over time, however with notably distinctive trajectories. These results are somewhat surprising, given our other observations for pain severity and disability, psychological distress, fatigue and HRQoL, which concurrently revealed unstable trends, rebound effects and potential worsening over time. Regarding pain catastrophising specifically, we found continuous, linear decreases for the EndoOnly group, suggesting potential increased resilience within this sample [81,82], or potentially greater use of adaptive coping strategies in response to pain [83]. Conversely, trends for individuals with Endo+IBS were not stable, and after an initial decline in levels of pain catastrophising, results rebounded or diminished over time. These findings suggest that the added burden of comorbid IBS-type symptoms may heighten catastrophic thinking about pain, or potentially increase individual sensitivity to cyclical changes or external and environmental stressors [71,84,85]. Given that health outcomes are directly affected by how individuals cope with and respond to pain, the development of personalised targeted interventions to address and support cognitive and emotional processes associated with pain catastrophising may help to optimise treatment success and improve overall QoL, for both individuals living with EndoOnly and individuals with Endo+IBS [79,85]. The COVID-19 global pandemic presented unprecedented health challenges and concerns, especially for individuals living with chronic conditions. In addition to the fear of contracting the SARS-CoV-2 virus, public health measures such as social distancing, mandatory lockdowns, and limitations on services, substantially impacted psychosocial wellbeing [86]. Individuals living with endometriosis have reported significant declines in physical, psychological and/or social health as a result of the COVID-19 pandemic [87,88], with similar negative outcomes reported by individuals with gastrointestinal disorders, such as IBS [89-92]. A recent meta-analysis exploring the impacts of COVID-19 on endometriosis ( N = 15) found that individuals with endometriosis experienced increased symptoms of pain, depression, anxiety, and fatigue during the pandemic [93], negatively compromising overall HRQoL. Paradoxically, this study observed trends towards improvements in outcome measures for both groups at 12-month follow-up (T2), particularly for the Endo+IBS group, which coincided with the peak of mandatory COVID-19 restrictions in Australia. Our findings are consistent with studies in endometriosis and IBS populations, which have demonstrated improved disease severity, enhanced symptom management, increased productivity, and lower condition-related stress resulting from COVID-19-related flexible working arrangements, reduced daily work commutes and limited exposure to extrinsic stressors [94-97]. Interestingly, we also observed rebound trends from T2 to T3 for most outcomes (supported, in part, by significant post hoc comparisons), most prominently for the Endo+IBS group. Our findings are consistent with global studies which have found that physical and mental health trajectories were significantly disrupted and showed complex patterns of change as a direct result of COVID-19 public health measures [98-101]. Notably, a recent survey of Australian adults ( N = 574,306) found that psychological distress initially increased during lockdown, however quickly stabilised, then rapidly declined after restrictions were lifted, but not to pre-COVID-19 levels [102]. Furthermore, although we did not collect data on confirmed SARS-CoV-2 infections, emerging evidence suggests that exposure to the SARS-CoV-2 virus potentially causes long-term changes in gut-brain messaging that may lead to IBS or other disordered gut-brain interactions [90,103]. Studies have shown that individuals who have previously contracted the SARS-Cov-2 virus have reported increased rates of post-infection IBS and more severe gastrointestinal issues [104,105]. Moreover, exposure to the SARS-Cov-2 virus appears to worsen pre-existing symptoms for individuals already living with IBS [106]. Our findings suggest that COVID-19 public health restrictions had a marked and considerable influence on the health outcome trajectories for both groups, particularly for the Endo+IBS group, and most likely explains the inconsistent and unpredictable trajectories observed. Furthermore, the emerging evidence supporting the link between the SARS-CoV-2 virus and gastrointestinal manifestations should not be ignored and may provide deeper insights into the unusual patterns of change and the burden of living with IBS comorbidity. Future studies should examine whether these effects are uniquely transitory, or if there are ongoing, residual influences of COVID-19 restrictions and/or the SARS-CoV-2 virus that may influence health outcomes for these populations. Although comorbidity is very common and has significant detrimental impacts on individuals and the healthcare system more broadly, research exploring the development of targeted interventions and tailored approaches to health management are limited [107]. By understanding the trajectories and changes in health outcomes for individuals living with endometriosis and comorbid IBS, healthcare providers can improve condition management and treatment success, and help to identify person-centred, adaptive approaches that respond to individual requirements, symptoms, and priorities. Our research underscores the need for greater practitioner awareness of the relationship between endometriosis and IBS to mitigate misdiagnosis, mistreatment, and diagnostic delays. Furthermore, study findings provide evidence-based insights to inform healthcare practices and strategies that may alleviate the long-term health impact of comorbid IBS and help to promote greater wellbeing and HRQoL. Accordingly, a multidisciplinary approach to managing these complex and multifactorial conditions is strongly recommended and critically needed to enhance the patient experience and improve health outcomes overall. Finally, our observations contribute to the growing body of research examining the physical and psychosocial health consequences of COVID-19, potentially informing further studies and public health responses. Future research should focus on exploring the underlying mechanisms of comorbid relationships, including shared risk factors and genetic biological markers [59,108,109], along with examining the complex interaction of health behaviours, psychological processes, and extrinsic factors, to help optimise the health and wellbeing of individuals living with endometriosis and endometriosis with co-occurring IBS. Strengths of this study include the prospective design, with follow-up of the same cohort across three years, along with the sample size, which was sufficient to power the study. Notwithstanding, our findings should be interpreted in the context of study limitations. Firstly, the attrition rate was high and individual item data was missing. However, loss to follow up is common in longitudinal studies and the application of LMM analyses may help to mitigate any potential biases. The use of self-selected sampling and self-reported measures to collect participant data, along with the use of Rome-IV to categorise participants with IBS-type symptoms also raises the potential for representation and information bias. It is also recognised that certain types of endometrioses (for example bowel endometriosis) may have over-estimated the presence of IBS in this study and future research should potentially identify and/or specify different types of endometriosis sub-groups. Further, the original sample of women with dysmenorrhea may not be representative of the broader population, limiting our generalisability. Finally, the lack of observed interaction effects may have been influenced by shared external factors, such as COVID-19 restrictions, which potentially produced the large number of quadratic effects and unusual trajectories observed in this study. Future research, including a follow up survey with this sample, is needed to examine the identified outcome variables in typical or unaffected environmental contexts and to properly elucidate any potential impacts and patterns of change. In conclusion, this longitudinal study provides valuable insight into the complex changes and differences of biopsychosocial outcomes between individuals with endometriosis and individuals with endometriosis and co-occurring IBS-type symptoms over time. It highlights the enduring and pervasive influence of comorbid IBS-type symptoms on health and wellbeing and emphasises the need for individualised and adaptable interventions and healthcare approaches that meet the unique challenges faced by individuals living with comorbidity. Future research should focus on the underlying mechanisms, processes and potential environmental stressors that influence the long-term health of individuals living with endometriosis and IBS-type symptoms, to optimise health outcomes, individual wellbeing and overall HRQoL. Declarations Data Availability The de-identified, anonymised data underlying this article may be shared on reasonable request to the corresponding author. Acknowledgements The authors wish to acknowledge and thank the participants who contributed their time to complete the study and the organisations involved in participant recruitment and advertising of the study. Authors Contributions All authors were involved in the conception and design of the study. Authors S.C. and DS performed the data analysis and interpretation of results. Author S.C prepared the draft manuscript and Supplementary Information. All authors reviewed and contributed to the revised paper and approved the final article for publication. Competing Interests No specific funding was provided for this study. Author S.C is supported by a Commonwealth funded PhD scholarship. Author L.V.N is a member of the Endometriosis Australia Clinical Advisory Committee (non-financial) and the NECST Steering Committee (non-financial). Author A.M-W is a member of the NECST Steering Committee (non-financial). 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Interventions for improving outcomes in patients with multimorbidity in primary care and community setting: a systematic review. Systematic Reviews 10, https://doi.org/10.1186/s13643-021-01817-z (2021). McGrath, I. M., Montgomery, G. W., Mortlock, S. & International Endometriosis Genetics, C. Genomic characterisation of the overlap of endometriosis with 76 comorbidities identifies pleiotropic and causal mechanisms underlying disease risk. Human Genetics 142, 1345–1360, https://doi.org/10.1007/s00439-023-02582-w (2023). Rahmioglu, N. et al. The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions. Nature Genetics 55, 423–436, https://doi.org/10.1038/s41588-023-01323-z (2023). Additional Declarations Competing interest reported. No specific funding was provided for this study. Author S.C is supported by a Commonwealth funded PhD scholarship. Author L.V.N is a member of the Endometriosis Australia Clinical Advisory Committee (non-financial) and the NECST Steering Committee (non-financial). Author A.M-W is a member of the NECST Steering Committee (non-financial). Authors S.E and A.M-W are recipients of several grants from the Medical Research Future Fund (MRFF), Victorian Government Department of Health and philanthropic organisations for the development and testing of psychological interventions to support people living with persistent pelvic pain, including endometriosis, outside of this research study. Author D.S has no financial or non-financial competing interests to declare. Supplementary Files SupplementaryInformationFinalSR1.xlsx Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4505378","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":313047711,"identity":"f7564ceb-b257-4653-9e94-6d8b0e19361a","order_by":0,"name":"Suiyin Cheah","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA4UlEQVRIiWNgGAWjYDACCQYGZgYGG8YGBjaGA0A+kEGcljTStRwGa2EgSgv/7OaDnwv+nJftZz+WeLiAwUZ2wwHmZxJ4LblzLFl6Zttt45k9aQcOz2BIM95wgM0MrxYDiRwDad6G24kbDqQ3HOZhOAxkMBDSkv/5N8+fc4n7zz8HafkP1ML+jZAtbNI8bAcSN0gAHcbDAGQc4MFvi8SNNDNr3rZk4xk3niUc5jFINp55mKfYAp8W/hnJj2/z/LGT7e9PM/7MU2En23e8feMNfFrQ3ckAjqZRMApGwSgYBRQCAD6QTUkSrOZdAAAAAElFTkSuQmCC","orcid":"","institution":"Deakin University","correspondingAuthor":true,"prefix":"","firstName":"Suiyin","middleName":"","lastName":"Cheah","suffix":""},{"id":313047712,"identity":"adde618b-a221-4cee-866d-a79c679b11ca","order_by":1,"name":"David Skvarc","email":"","orcid":"","institution":"Deakin University","correspondingAuthor":false,"prefix":"","firstName":"David","middleName":"","lastName":"Skvarc","suffix":""},{"id":313047713,"identity":"31808de2-8145-4647-b852-b4a3db4716a7","order_by":2,"name":"Subhadra Evans","email":"","orcid":"","institution":"Deakin University","correspondingAuthor":false,"prefix":"","firstName":"Subhadra","middleName":"","lastName":"Evans","suffix":""},{"id":313047714,"identity":"45e6e6ec-3700-4a30-bd61-9498d5563fef","order_by":3,"name":"Leesa Van Niekerk","email":"","orcid":"","institution":"University of Tasmania","correspondingAuthor":false,"prefix":"","firstName":"Leesa","middleName":"Van","lastName":"Niekerk","suffix":""},{"id":313047715,"identity":"1c802b8d-70d6-4d00-9f9c-208ca55c68ee","order_by":4,"name":"Antonina Mikocka-Walus","email":"","orcid":"","institution":"Deakin University","correspondingAuthor":false,"prefix":"","firstName":"Antonina","middleName":"","lastName":"Mikocka-Walus","suffix":""}],"badges":[],"createdAt":"2024-05-30 23:56:00","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-4505378/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-4505378/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":58595300,"identity":"41cc6215-b2b3-4de3-8ffc-3aa4dbaf8e16","added_by":"auto","created_at":"2024-06-18 16:37:56","extension":"png","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":23662,"visible":true,"origin":"","legend":"\u003cp\u003ePain Catatrophising (Rumination and Total Pain Catastrophising) by Group (EndoOnly; Endo+IBS) Over Time\u003c/p\u003e\n\u003cp\u003eSignificant group (EndoOnly; Endo+IBS) effects at baseline, 12-month and 24-months for the pain catastrophising for \u003cstrong\u003ea)\u003c/strong\u003e rumination and \u003cstrong\u003eb)\u003c/strong\u003e total pain catastrophising as measured by the Pain Catastrophizing Scale.\u003c/p\u003e","description":"","filename":"1.png","url":"https://assets-eu.researchsquare.com/files/rs-4505378/v1/56993b6fe002fbd302b76230.png"},{"id":58595298,"identity":"b4715d8f-1d65-4fa5-9b83-da18e19838a1","added_by":"auto","created_at":"2024-06-18 16:37:56","extension":"png","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":16138,"visible":true,"origin":"","legend":"\u003cp\u003ePain Severity by Group (EndoOnly; Endo+IBS) Over Time\u003c/p\u003e\n\u003cp\u003eSignificant group (EndoOnly; Endo+IBS) effects at baseline, 12-month and 24-months for pain severity as measured by the Menstrual Symptom Scale.\u003c/p\u003e","description":"","filename":"2.png","url":"https://assets-eu.researchsquare.com/files/rs-4505378/v1/bd80bc8c96837cdeab49ace6.png"},{"id":58595301,"identity":"7e7074b9-e08a-4c2a-9be0-12ca1eb520c4","added_by":"auto","created_at":"2024-06-18 16:37:56","extension":"png","order_by":3,"title":"Figure 3","display":"","copyAsset":false,"role":"figure","size":18039,"visible":true,"origin":"","legend":"\u003cp\u003eHelplessness by Group (EndoOnly; Endo+IBS) Over Time\u003c/p\u003e\n\u003cp\u003eSignificant group (EndoOnly; Endo+IBS) effects at baseline, 12-month and 24-months for helplessness as measured by the Pain Catastrophizing Scale helplessness subscale.\u003c/p\u003e","description":"","filename":"3.png","url":"https://assets-eu.researchsquare.com/files/rs-4505378/v1/d2f7e1849d35ceed57c036b8.png"},{"id":69927489,"identity":"7f202a19-d1c1-4aa0-8baa-1b012de1e16e","added_by":"auto","created_at":"2024-11-26 16:47:22","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":2197793,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-4505378/v1/da173d05-35b3-4cab-bbd0-89615849661e.pdf"},{"id":58595299,"identity":"d24cb42e-4a4a-4d85-b861-8f7220120a14","added_by":"auto","created_at":"2024-06-18 16:37:56","extension":"xlsx","order_by":2,"title":"","display":"","copyAsset":false,"role":"supplement","size":48794,"visible":true,"origin":"","legend":"","description":"","filename":"SupplementaryInformationFinalSR1.xlsx","url":"https://assets-eu.researchsquare.com/files/rs-4505378/v1/a32e6e260d2a2e32a1921eb6.xlsx"}],"financialInterests":"Competing interest reported. No specific funding was provided for this study. Author S.C is supported by a Commonwealth funded PhD scholarship. Author L.V.N is a member of the Endometriosis Australia Clinical Advisory Committee (non-financial) and the NECST Steering Committee (non-financial). Author A.M-W is a member of the NECST Steering Committee (non-financial). Authors S.E and A.M-W are recipients of several grants from the Medical Research Future Fund (MRFF), Victorian Government Department of Health and philanthropic organisations for the development and testing of psychological interventions to support people living with persistent pelvic pain, including endometriosis, outside of this research study. Author D.S has no financial or non-financial competing interests to declare.","formattedTitle":"Exploring Biopsychosocial Health Outcomes in Endometriosis and Endometriosis with Co-occurring Irritable Bowel Syndrome – A Prospective Cohort Study","fulltext":[{"header":"Introduction","content":"\u003cp\u003eEndometriosis is a debilitating, inflammatory, and chronic condition where endometrial-like tissue grows outside of the uterus [\u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e, \u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2\u003c/span\u003e]. It affects approximately 10% of all reproductive-aged women and individuals assigned female at birth [\u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e]. Comorbidities are commonly reported [\u003cspan additionalcitationids=\"CR5\" citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e], and significant associations with gynaecological conditions, chronic diseases [\u003cspan citationid=\"CR7\" class=\"CitationRef\"\u003e7\u003c/span\u003e, \u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e8\u003c/span\u003e], pain conditions [\u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e, \u003cspan citationid=\"CR10\" class=\"CitationRef\"\u003e10\u003c/span\u003e], and psychological disorders [\u003cspan citationid=\"CR11\" class=\"CitationRef\"\u003e11\u003c/span\u003e, \u003cspan citationid=\"CR12\" class=\"CitationRef\"\u003e12\u003c/span\u003e], have been found. Gastrointestinal symptoms are highly prevalent among individuals with endometriosis [\u003cspan citationid=\"CR13\" class=\"CitationRef\"\u003e13\u003c/span\u003e, \u003cspan citationid=\"CR14\" class=\"CitationRef\"\u003e14\u003c/span\u003e], with up to 90% reporting gastrointestinal complaints [\u003cspan citationid=\"CR15\" class=\"CitationRef\"\u003e15\u003c/span\u003e, \u003cspan citationid=\"CR16\" class=\"CitationRef\"\u003e16\u003c/span\u003e]. Varied symptom profiles, with common comorbidities make diagnosis and treatment difficult [\u003cspan citationid=\"CR17\" class=\"CitationRef\"\u003e17\u003c/span\u003e], compromising daily functioning and health-related quality of life (HRQoL; [\u003cspan citationid=\"CR13\" class=\"CitationRef\"\u003e13\u003c/span\u003e, \u003cspan citationid=\"CR18\" class=\"CitationRef\"\u003e18\u003c/span\u003e, \u003cspan citationid=\"CR19\" class=\"CitationRef\"\u003e19\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eIrritable bowel syndrome (IBS) is a common, chronic disorder of the gut-brain interaction, with similar prevalence and symptomology to endometriosis [\u003cspan citationid=\"CR20\" class=\"CitationRef\"\u003e20\u003c/span\u003e, \u003cspan citationid=\"CR21\" class=\"CitationRef\"\u003e21\u003c/span\u003e]. It is closely associated with pelvic pain, psychological disorders, and fatigue, which negatively impact functioning and overall wellbeing [\u003cspan additionalcitationids=\"CR23 CR24\" citationid=\"CR22\" class=\"CitationRef\"\u003e22\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR25\" class=\"CitationRef\"\u003e25\u003c/span\u003e]. Associations between endometriosis and IBS have been increasingly noted [\u003cspan citationid=\"CR13\" class=\"CitationRef\"\u003e13\u003c/span\u003e, \u003cspan citationid=\"CR26\" class=\"CitationRef\"\u003e26\u003c/span\u003e, \u003cspan citationid=\"CR27\" class=\"CitationRef\"\u003e27\u003c/span\u003e], and common pathophysiological mechanisms, including chronic inflammation, alterations in pain processing and the gut-brain axis, mast cell activation and altered immune function have been proposed [\u003cspan citationid=\"CR13\" class=\"CitationRef\"\u003e13\u003c/span\u003e, \u003cspan citationid=\"CR14\" class=\"CitationRef\"\u003e14\u003c/span\u003e, \u003cspan additionalcitationids=\"CR29\" citationid=\"CR28\" class=\"CitationRef\"\u003e28\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR30\" class=\"CitationRef\"\u003e30\u003c/span\u003e]. Overlapping symptoms of the two conditions often results in repeated medical testing, misdiagnosis, and diagnostic delays, leading to increased healthcare utilisation [\u003cspan citationid=\"CR31\" class=\"CitationRef\"\u003e31\u003c/span\u003e], treatment complications and prolonged suffering and pain [\u003cspan citationid=\"CR13\" class=\"CitationRef\"\u003e13\u003c/span\u003e, \u003cspan citationid=\"CR32\" class=\"CitationRef\"\u003e32\u003c/span\u003e]. Diagnostic challenges are further compounded by the lack of established biomarkers and non-invasive diagnostics tests for both conditions [\u003cspan citationid=\"CR33\" class=\"CitationRef\"\u003e33\u003c/span\u003e]. Moreover, both endometriosis and IBS are associated with reduced psychological health [\u003cspan citationid=\"CR25\" class=\"CitationRef\"\u003e25\u003c/span\u003e, \u003cspan citationid=\"CR34\" class=\"CitationRef\"\u003e34\u003c/span\u003e], increased pain and pain catastrophising [\u003cspan additionalcitationids=\"CR36\" citationid=\"CR35\" class=\"CitationRef\"\u003e35\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR37\" class=\"CitationRef\"\u003e37\u003c/span\u003e], impaired social and intimate relationships [\u003cspan citationid=\"CR38\" class=\"CitationRef\"\u003e38\u003c/span\u003e, \u003cspan citationid=\"CR39\" class=\"CitationRef\"\u003e39\u003c/span\u003e] and greater fatigue [\u003cspan citationid=\"CR23\" class=\"CitationRef\"\u003e23\u003c/span\u003e, \u003cspan citationid=\"CR40\" class=\"CitationRef\"\u003e40\u003c/span\u003e], adversely influencing daily functioning and overall quality of life (QoL; [\u003cspan citationid=\"CR18\" class=\"CitationRef\"\u003e18\u003c/span\u003e, \u003cspan citationid=\"CR22\" class=\"CitationRef\"\u003e22\u003c/span\u003e] ). Given both conditions are highly prevalent, chronic, and multifactorial, obtaining further insights into their relationship and the associated biopsychosocial influences may help to improve health provider awareness, optimise disease management, and facilitate personalised, interdisciplinary treatment and care.\u003c/p\u003e \u003cp\u003eAlthough endometriosis and IBS are associated with poorer health outcomes, little is known about the compounding effect of endometriosis with co-occurring IBS-type symptoms on individual wellbeing and HRQoL. Furthermore, prospective studies exploring the effects of comorbidities on physical and psychosocial health outcomes for individuals living with endometriosis are scarce. Accordingly, this study aimed to investigate the longitudinal changes and differences in biopsychosocial factors (HRQoL, psychological distress, pain (severity, interference and catastrophising), fatigue, and menstrual symptoms) in individuals with endometriosis, with and without co-occurring IBS-type symptoms, over time. It was hypothesised that individuals with endometriosis and co-occurring IBS-type symptoms would report poorer biopsychosocial outcomes compared with individuals with endometriosis alone at baseline. It was also hypothesised that individuals with endometriosis and co-occurring IBS-type symptoms would report poorer biopsychosocial outcomes compared to individuals with endometriosis alone over three years.\u003c/p\u003e"},{"header":"Materials and Methods","content":"\u003cp\u003e\u003cstrong\u003eParticipants\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThis longitudinal prospective cohort study was nested within a larger community population study examining the physical and psychosocial impact of pelvic pain on Australian women\u0026nbsp;[41]. A convenience sample of Australian women aged 18-50 years, who had experienced a period in the last 12 months, completed online surveys on three occasions: baseline (T1), 12 months (T2) and 24 months (T3) between 2019 and 2021. Participants were recruited via social media platforms, women\u0026rsquo;s gyms, and university forum sites (see:\u0026nbsp;[41]). The sample for this study was restricted to women with endometriosis (EndoOnly) and women with endometriosis and co-occurring IBS-type symptoms (Endo+IBS). Eligibility criteria for each group was determined by self-reported clinical diagnosis (e.g., laparoscopy, medical ultrasound for endometriosis; satisfaction of Rome IV diagnostic criteria for IBS), as well as self-reported illness (i.e., a \u0026lsquo;yes\u0026rsquo; response to the survey question: \u003cem\u003eDo you have any chronic illnesses?\u003c/em\u003e).\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eEthical Approval\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eEthics approval was obtained from the Deakin University Human Research Ethics Committee (HEAG-H 10_2019). The study was performed in accordance with the Declaration of Helsinki and in line with relevant guidelines and/or regulations. All participants provided informed consent prior to joining the study and were free to withdraw from the study at any time.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eOutcomes Measures\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eDemographic and health-related data, including participant age, ethnicity, employment status, education level, marital status, and health-related lifestyle behaviour data (e.g., smoking and alcohol consumption) were collected at baseline. Gastrointestinal symptom data were collected at baseline using the relevant section of the Rome IV diagnostic questionnaire\u0026nbsp;[42]. Participants were categorised based on the presence or absence of Rome IV-defined IBS, in accordance with the questionnaire criteria.\u003c/p\u003e\n\u003cp\u003e\u003cem\u003eHealth-Related Quality of Life\u003c/em\u003e\u003c/p\u003e\n\u003cp\u003eHRQoL was measured using the 26-item World Health Organisation Quality of Life Assessment (WHOQOL-BREF;\u0026nbsp;[43]), a self-administered questionnaire assessing four HRQoL domains: psychological health, physical health, social relationships, and environmental health. Each individual item is scored on a five-point ordinal scale from 1 to 5, with higher scores indicating higher HRQoL. The WHOQOL-BREF has shown good internal consistency(\u0026alpha; \u0026gt; 0.90;\u0026nbsp;[43,44])\u003c/p\u003e\n\u003cp\u003e\u003cem\u003ePsychological Distress\u003c/em\u003e\u003c/p\u003e\n\u003cp\u003ePsychological distress was evaluated using the 21-item Depression Anxiety and Stress Scale (DASS-21;\u0026nbsp;[45,46]), a self-report measure assessing symptoms of anxiety, depression, and stress. Each subscale\u0026nbsp;is used as an indicator of emotional distress,\u0026nbsp;and consists of seven items, rated on a four-point scale from 0 to 3,\u0026nbsp;with higher scores indicating greater levels of psychological distress.\u0026nbsp;The DASS-21 has shown good internal consistency (\u0026alpha; = 0.92;\u0026nbsp;[45])\u003c/p\u003e\n\u003cp\u003e\u003cem\u003ePain Severity\u003c/em\u003e\u003c/p\u003e\n\u003cp\u003eMenstrual pain severity was measured with a single item numeric rating scale (NRS;\u0026nbsp;[47]\u0026nbsp;to rate \u0026lsquo;\u003cem\u003ewhat is your usual level of endometriosis pain (without pain medicine)\u003c/em\u003e?\u0026rsquo;. Scores ranged from 0 (no pain) to 10 (worst pain possible) and were categorised as: mild pain (scores 1-4), moderate pain (scores 5\u0026ndash;7), or severe pain (scores 8\u0026ndash;10), consistent with previous approaches\u0026nbsp;[48,49]. The NRS has demonstrated acceptable validity in individuals with menstrual pain\u0026nbsp;[47].\u003c/p\u003e\n\u003cp\u003e\u003cem\u003eFunctional Pain Disability\u003c/em\u003e\u003c/p\u003e\n\u003cp\u003eFunctional pain disability was measured using one subscale of the Brief Pain Inventory (BPI;\u0026nbsp;[50]), to assess pain interference experienced in the past 24 hours, using an 11-point scale (where 0 = does not interfere, and 10 = completely interferes). The sub-scale comprises of seven pain interference items evaluating different domains including general activity, relations with others and enjoyment of life, with higher scores indicating increased functional pain impairment. The BPI has shown acceptable internal consistency \u0026nbsp;in both pain and non-pain populations (\u0026alpha; = 0.70 to 0.88;\u0026nbsp;[51,52]).\u003c/p\u003e\n\u003cp\u003e\u003cem\u003ePain Catastrophising\u003c/em\u003e\u003c/p\u003e\n\u003cp\u003ePain catastrophising was measured using the 13-item Pain Catastrophizing Scale (PCS;\u0026nbsp;[53], which assesses pain-related magnification, rumination, helplessness and total pain catastrophising. The measure uses a 5-point Likert scale to produce a total score (0\u0026ndash;52), with higher scores indicating higher levels of pain catastrophising. A total score of 30 or more indicates a clinically significant level of catastrophizing. The PCS has shown high internal consistency, (\u0026alpha; = .93;[53]).\u003c/p\u003e\n\u003cp\u003e\u003cem\u003eFatigue\u003c/em\u003e\u003c/p\u003e\n\u003cp\u003eFatigue was assessed using the Fatigue Symptom Inventory (FSI;\u0026nbsp;[54]),\u0026nbsp;a 14-item self-report questionnaire evaluating the severity, frequency and daily pattern of fatigue and its observed interference with QoL. Items are scored using an 11-point scale. This study calculated a total disruption index score by summing items 5-11. The FSI has shown good validity and reliability (\u0026alpha; = 0.84 to 0.96;[54]).\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cem\u003eMenstrual Symptoms\u003c/em\u003e\u003c/p\u003e\n\u003cp\u003eA validated numerical rating scale\u0026nbsp;[47]\u0026nbsp;was used to assess the perceived severity of nine common menstrual symptoms (e.g., abdominal cramps, lower back pain) experienced over the past six months. The measure uses a scale ranging from 0 (not present) to 10 (extremely severe), with higher scores indicating an increased presence of dysmenorrhea symptoms.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCovariates\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eAge (in years), contraceptive pill usage, age of menarche (in years) and body mass index (BMI) were included as covariates due to their association with endometriosis, IBS, and the outcome variables of interest.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eData Analysis\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eData from the original study were collected using Qualtrics. All statistical analyses were performed using Jamovi software (The Jamovi Project, 2021) and the GAMlj package (version 3.0). Baseline group comparisons of continuous variables were assessed using ANOVA, and chi-squared tests were used for categorical variable comparisons. Little\u0026rsquo;s MCAR test was undertaken to examine if data were missing at random.\u003c/p\u003e\n\u003cp\u003eRestricted maximum likelihood linear mixed models (LMM) were used to investigate differences in outcome variables between the groups (EndoOnly, Endo+IBS) over time. LMM analyses were selected for their ability to manage multiple observations and handle missing data without compromising power [55,56]. Each model included random intercepts for participant clusters, and was adjusted for age, contraceptive pill usage, age of menarche, and BMI. Outcome data was visually inspected using histograms to check the distribution of the residuals. No transformations were required. To analyse potential trends in the means of the groups, polynomial contrast estimates were fit for time (linear, quadratic) and post hoc comparisons. Simple effects of time analyses were undertaken for all models. Given the study\u0026apos;s exploratory nature, we continued with our analysis and interpretation of the data, even when the omnibus main effects or interaction effects were statistically insignificant, and no adjustments for multiple comparisons were made. Due to the large number of outcome measures, only statistically significant or clinically relevant results have been reported. A comprehensive summary of findings is available in the Supplementary Information File (SI1 \u0026ndash; SI5).\u003c/p\u003e"},{"header":"Results","content":"\u003cp\u003e\u003cstrong\u003eStudy Population\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eAt baseline, 610 participants were included in the study. From the original sample of 2,426 we excluded participants who did not report a diagnosis of endometriosis or IBS, nor symptoms characteristic of either condition (\u003cem\u003eN\u0026nbsp;\u003c/em\u003e= 1,854). Of the 610 included participants, 352 (57.7%) \u0026nbsp;constituted the EndoOnly group and 258 (42.3%) the Endo+IBS group.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eParticipant Characteristics\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eParticipant characteristics by group at baseline are provided in \u003cstrong\u003eTable 1\u003c/strong\u003e. No significant differences between the EndoOnly and Endo+IBS groups were observed for any demographic or health-related characteristics. All participants were female and resided in Australia. Most participants were employed (76.4%) and tertiary educated (78.9%). Participants identified as Anglo (\u003cem\u003en\u0026nbsp;\u003c/em\u003e= 512; 83.9%), European (\u003cem\u003en\u0026nbsp;\u003c/em\u003e= 143; 23.4%), Chinese (\u003cem\u003en\u0026nbsp;\u003c/em\u003e= 3; 0.5%), Indian (\u003cem\u003en\u0026nbsp;\u003c/em\u003e= 9; 1.5%) or Other Asian (\u003cem\u003en\u0026nbsp;\u003c/em\u003e= 27; 4.4%) ethnic groups.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTable 1\u0026nbsp;\u003c/strong\u003e- Participants\u0026apos; descriptive statistics at baseline and test of differences between EndoOnly and Endo+IBS\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003ctable border=\"1\" cellspacing=\"0\" cellpadding=\"0\" width=\"681\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd width=\"32.011747430249635%\" valign=\"top\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd width=\"67.98825256975037%\" colspan=\"5\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eTotal (N = 610)\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"32.05882352941177%\" valign=\"top\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd width=\"23.529411764705884%\" colspan=\"2\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eEndo Only (n = 352)\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.41176470588235%\" colspan=\"2\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eEndo+IBS (n = 258)\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eTest of differences\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"32.05882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eAge - years (\u003cem\u003eM, SDs\u003c/em\u003e)\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.823529411764707%\" valign=\"top\"\u003e\n \u003cp\u003e29.92\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e7.55\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e30.16\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e6.57\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cem\u003eF\u003c/em\u003e(1, 584) = 0.18, \u003cem\u003ep\u003c/em\u003e = 0.676\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"32.05882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eSex (%, number)\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.823529411764707%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cem\u003e\u0026chi;\u0026sup2;\u003c/em\u003e(1) = 0.00, p = 1.000\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"32.05882352941177%\" valign=\"top\"\u003e\n \u003cp\u003eFemale\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.823529411764707%\" valign=\"top\"\u003e\n \u003cp\u003e100%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e352\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e100%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e258\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"32.05882352941177%\" valign=\"top\"\u003e\n \u003cp\u003eMale\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.823529411764707%\" valign=\"top\"\u003e\n \u003cp\u003e0%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e0\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e0%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e0\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"32.05882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eEducation (%, number)\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.823529411764707%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd width=\"25%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cem\u003e\u0026chi;\u0026sup2;\u003c/em\u003e(6) = 7.75, \u003cem\u003ep\u003c/em\u003e = 0.257\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"32.05882352941177%\" valign=\"top\"\u003e\n \u003cp\u003eLess that year 12\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.823529411764707%\" valign=\"top\"\u003e\n \u003cp\u003e4.0\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e14\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e3.9\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e10\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\" valign=\"top\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"32.05882352941177%\" valign=\"top\"\u003e\n \u003cp\u003eYear 12 or equivalent\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.823529411764707%\" valign=\"top\"\u003e\n \u003cp\u003e17.0\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e60\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e20.5\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e53\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\" valign=\"top\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"32.05882352941177%\" valign=\"top\"\u003e\n \u003cp\u003eVocational education (TAFE)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.823529411764707%\" valign=\"top\"\u003e\n \u003cp\u003e22.2\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e78\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e28.3\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e73\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\" valign=\"top\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"32.05882352941177%\" valign=\"top\"\u003e\n \u003cp\u003eBachelor\u0026rsquo;s degree\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.823529411764707%\" valign=\"top\"\u003e\n \u003cp\u003e36.6\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e129\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e31.4\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e81\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\" valign=\"top\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"32.05882352941177%\" valign=\"top\"\u003e\n \u003cp\u003eMaster\u0026rsquo;s degree\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.823529411764707%\" valign=\"top\"\u003e\n \u003cp\u003e11.9\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e42\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e7.4\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e19\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\" valign=\"top\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"32.05882352941177%\" valign=\"top\"\u003e\n \u003cp\u003ePhD / doctorate\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.823529411764707%\" valign=\"top\"\u003e\n \u003cp\u003e1.1\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e1.6\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\" valign=\"top\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"32.05882352941177%\" valign=\"top\"\u003e\n \u003cp\u003eOther (please specify)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.823529411764707%\" valign=\"top\"\u003e\n \u003cp\u003e7.1\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e25\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e7.0\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e18\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\" valign=\"top\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"32.05882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eMarital Status (%, number)\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.823529411764707%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd width=\"25%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cem\u003e\u0026chi;\u0026sup2;\u003c/em\u003e(5) = 4.21, \u003cem\u003ep\u003c/em\u003e = 0.520\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"32.05882352941177%\" valign=\"top\"\u003e\n \u003cp\u003eSingle (never married)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.823529411764707%\" valign=\"top\"\u003e\n \u003cp\u003e36.9\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e130\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e37.6\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e97\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\" valign=\"top\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"32.05882352941177%\" valign=\"top\"\u003e\n \u003cp\u003eMarried / de facto\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.823529411764707%\" valign=\"top\"\u003e\n \u003cp\u003e56.3\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e198\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e56.6\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e146\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\" valign=\"top\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"32.05882352941177%\" valign=\"top\"\u003e\n \u003cp\u003eWidowed\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.823529411764707%\" valign=\"top\"\u003e\n \u003cp\u003e0.0\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e0\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e0.4\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\" valign=\"top\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"32.05882352941177%\" valign=\"top\"\u003e\n \u003cp\u003eDivorced\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.823529411764707%\" valign=\"top\"\u003e\n \u003cp\u003e3.7\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e13\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e3.1\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e8\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\" valign=\"top\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"32.05882352941177%\" valign=\"top\"\u003e\n \u003cp\u003eSeparated\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.823529411764707%\" valign=\"top\"\u003e\n \u003cp\u003e2.3\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e8\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e0.8\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\" valign=\"top\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"32.05882352941177%\" valign=\"top\"\u003e\n \u003cp\u003eOther (please specify)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.823529411764707%\" valign=\"top\"\u003e\n \u003cp\u003e0.9\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e1.6\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\" valign=\"top\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"32.05882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eEmployment Status (%, number)\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.823529411764707%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd width=\"25%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cem\u003e\u0026chi;\u0026sup2;\u003c/em\u003e(8) = 14.7, \u003cem\u003ep\u003c/em\u003e = 0.065\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"32.05882352941177%\" valign=\"top\"\u003e\n \u003cp\u003eEmployed full time\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.823529411764707%\" valign=\"top\"\u003e\n \u003cp\u003e48.0\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e169\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e45.7\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e118\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\" valign=\"top\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"32.05882352941177%\" valign=\"top\"\u003e\n \u003cp\u003eEmployed part time\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.823529411764707%\" valign=\"top\"\u003e\n \u003cp\u003e23.3\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e82\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e23.3\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e60\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\" valign=\"top\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"32.05882352941177%\" valign=\"top\"\u003e\n \u003cp\u003eUnemployed currently looking for work\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.823529411764707%\" valign=\"top\"\u003e\n \u003cp\u003e1.1\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e3.9\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e10\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\" valign=\"top\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"32.05882352941177%\" valign=\"top\"\u003e\n \u003cp\u003eUnemployed not currently looking for work\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.823529411764707%\" valign=\"top\"\u003e\n \u003cp\u003e1.1\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e0.8\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\" valign=\"top\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"32.05882352941177%\" valign=\"top\"\u003e\n \u003cp\u003eStudent\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.823529411764707%\" valign=\"top\"\u003e\n \u003cp\u003e12.5\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e44\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e7.8\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e20\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\" valign=\"top\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"32.05882352941177%\" valign=\"top\"\u003e\n \u003cp\u003eHomemaker\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.823529411764707%\" valign=\"top\"\u003e\n \u003cp\u003e2.3\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e8\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e4.7\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e12\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\" valign=\"top\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"32.05882352941177%\" valign=\"top\"\u003e\n \u003cp\u003eSelf-employed\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.823529411764707%\" valign=\"top\"\u003e\n \u003cp\u003e5.1\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e18\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e3.5\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e9\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\" valign=\"top\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"32.05882352941177%\" valign=\"top\"\u003e\n \u003cp\u003eUnable to work\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.823529411764707%\" valign=\"top\"\u003e\n \u003cp\u003e2.8\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e10\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e4.3\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e11\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\" valign=\"top\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"32.05882352941177%\" valign=\"top\"\u003e\n \u003cp\u003eOther (please specify)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.823529411764707%\" valign=\"top\"\u003e\n \u003cp\u003e3.7\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e13\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e6.2\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e16\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\" valign=\"top\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"32.05882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eAboriginal or Torres Strait Islander (%, number)\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.823529411764707%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd width=\"25%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cem\u003e\u0026chi;\u0026sup2;\u003c/em\u003e(1) = 1.34, \u003cem\u003ep\u003c/em\u003e = 0.248\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"32.05882352941177%\" valign=\"top\"\u003e\n \u003cp\u003eYes\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.823529411764707%\" valign=\"top\"\u003e\n \u003cp\u003e2.3\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e8\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e3.9\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e10\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\" valign=\"top\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"32.05882352941177%\" valign=\"top\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.823529411764707%\" valign=\"top\"\u003e\n \u003cp\u003e97.7\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e344\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e96.1\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e248\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\" valign=\"top\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"32.05882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eChildren (%, number)\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.823529411764707%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd width=\"25%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cem\u003e\u0026chi;\u0026sup2;\u003c/em\u003e(1) = 0.14, \u003cem\u003ep\u003c/em\u003e = 0.706\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"32.05882352941177%\" valign=\"top\"\u003e\n \u003cp\u003eYes\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.823529411764707%\" valign=\"top\"\u003e\n \u003cp\u003e28.1\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e99\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e26.7\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e69\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\" valign=\"top\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"32.05882352941177%\" valign=\"top\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.823529411764707%\" valign=\"top\"\u003e\n \u003cp\u003e71.9\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e253\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e73.3\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e189\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\" valign=\"top\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"32.05882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eAge of Menarche (\u003cem\u003eM, SDs\u003c/em\u003e)\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.823529411764707%\" valign=\"top\"\u003e\n \u003cp\u003e12.49\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e1.67\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e12.50\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e1.70\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cem\u003eF\u003c/em\u003e(1, 608) = 1.72e-04, \u003cem\u003ep\u003c/em\u003e = 0.99\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"32.05882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eContraceptive Pill Usage\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003cp\u003e\u003cstrong\u003e(%, number)\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.823529411764707%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd width=\"25%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cem\u003e\u0026chi;\u0026sup2;\u003c/em\u003e(1) = 0.42, \u003cem\u003ep\u003c/em\u003e = 0.516\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"32.05882352941177%\" valign=\"top\"\u003e\n \u003cp\u003eYes\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.823529411764707%\" valign=\"top\"\u003e\n \u003cp\u003e34.7\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e122\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e37.2\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e96\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\" valign=\"top\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"32.05882352941177%\" valign=\"top\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.823529411764707%\" valign=\"top\"\u003e\n \u003cp\u003e65.3\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e230\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e62.8\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e162\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\" valign=\"top\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"32.05882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eSmoking (%, number)\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.823529411764707%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd width=\"25%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cem\u003e\u0026chi;\u0026sup2;\u003c/em\u003e(2) = 1.19, \u003cem\u003ep\u003c/em\u003e = 0.551\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"32.05882352941177%\" valign=\"top\"\u003e\n \u003cp\u003eCurrent smoker\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.823529411764707%\" valign=\"top\"\u003e\n \u003cp\u003e7.4\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e26\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e9.7\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e25\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\" valign=\"top\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"32.05882352941177%\" valign=\"top\"\u003e\n \u003cp\u003eFormer smoker\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.823529411764707%\" valign=\"top\"\u003e\n \u003cp\u003e17.9\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e63\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e16.3\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e42\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\" valign=\"top\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"32.05882352941177%\" valign=\"top\"\u003e\n \u003cp\u003eNever smoked\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.823529411764707%\" valign=\"top\"\u003e\n \u003cp\u003e74.7\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e263\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e73.9\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e190\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\" valign=\"top\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"32.05882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eAlcohol (%, number)\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.823529411764707%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd width=\"25%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cem\u003e\u0026chi;\u0026sup2;\u003c/em\u003e(4) = 2.15, \u003cem\u003ep\u003c/em\u003e = 0.708\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"32.05882352941177%\" valign=\"top\"\u003e\n \u003cp\u003eMore than 2 standard drinks per day\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.823529411764707%\" valign=\"top\"\u003e\n \u003cp\u003e0.6\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e1.6\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\" valign=\"top\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"32.05882352941177%\" valign=\"top\"\u003e\n \u003cp\u003eFewer than 2 standard drinks per day\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.823529411764707%\" valign=\"top\"\u003e\n \u003cp\u003e2.0\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e7\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e2.3\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e6\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\" valign=\"top\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"32.05882352941177%\" valign=\"top\"\u003e\n \u003cp\u003eI drink several times a week\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.823529411764707%\" valign=\"top\"\u003e\n \u003cp\u003e9.9\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e35\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e8.1\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e21\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\" valign=\"top\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"32.05882352941177%\" valign=\"top\"\u003e\n \u003cp\u003eI occasionally drink\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.823529411764707%\" valign=\"top\"\u003e\n \u003cp\u003e70.5\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e248\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e71.7\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e185\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\" valign=\"top\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"32.05882352941177%\" valign=\"top\"\u003e\n \u003cp\u003eI never drink\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.823529411764707%\" valign=\"top\"\u003e\n \u003cp\u003e17.0\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e60\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e16.3\u0026thinsp;%\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e42\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\" valign=\"top\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"32.05882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eBMI (\u003cem\u003eM, SDs\u003c/em\u003e)\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"13.823529411764707%\" valign=\"top\"\u003e\n \u003cp\u003e28.11\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e6.77\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e27.17\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.705882352941176%\" valign=\"top\"\u003e\n \u003cp\u003e6.03\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"25%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cem\u003eF\u003c/em\u003e(1, 333) = 1.73, \u003cem\u003ep\u003c/em\u003e = 0.189\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003eDescriptive statistics were reported as mean\u0026thinsp;\u0026plusmn;\u0026thinsp;standard deviation and percentages. \u003cem\u003eM\u003c/em\u003e = mean, \u003cem\u003eSD\u003c/em\u003e = standard deviation,\u003cem\u003e\u0026nbsp;p\u003c/em\u003e\u0026thinsp;=\u0026thinsp;test of significance, two-tailed with a threshold of\u0026thinsp;\u0026lt;\u0026thinsp;0.05, \u003cem\u003e\u0026chi;\u0026sup2;\u0026nbsp;\u003c/em\u003e= test of difference (categorical variables),\u003cem\u003e\u0026nbsp;F\u0026nbsp;\u003c/em\u003e= ratio of two variances (independent samples)\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eOutcome Variables\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTable 2\u003c/strong\u003e presents each outcome variable\u0026apos;s means and standard deviations according to time and group. At baseline, findings showed that the Endo+IBS group reported worse outcomes compared with the EndoOnly group on HRQoL: physical (\u003cem\u003ep\u003c/em\u003e = 0.011), psychological (\u003cem\u003ep\u003c/em\u003e = 0.004) and social (\u003cem\u003ep\u003c/em\u003e = 0.013), psychological distress: depression (\u003cem\u003ep\u003c/em\u003e = 0.029), anxiety (\u003cem\u003ep\u0026nbsp;\u003c/em\u003e=0.017) and overall distress (\u003cem\u003ep\u003c/em\u003e = 0.022), functional pain disability (\u003cem\u003ep\u003c/em\u003e = 0.024), and menstrual symptoms (\u003cem\u003ep\u003c/em\u003e = \u0026lt;\u0026thinsp;.001). Notably, clinically relevant levels of pain catastrophizing were observed at baseline for both the EndoOnly (\u003cem\u003eM\u003c/em\u003e = 30.25, \u003cem\u003eSD\u0026nbsp;\u003c/em\u003e= 11.61) and Endo+IBS (\u003cem\u003eM\u0026nbsp;\u003c/em\u003e= 31.04, \u003cem\u003eSD\u003c/em\u003e = 11.23) groups. Results from Little\u0026rsquo;s MCAR test (\u0026gt;.05) and visual pattern inspection suggested that missing data at T3 were missing completely at random.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTable 2\u003c/strong\u003e - Descriptive statistics for outcome variables over time by group (EndoOnly,Endo+IBS)\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003ctable border=\"1\" cellspacing=\"0\" cellpadding=\"0\" width=\"680\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd width=\"31.91176470588235%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"23.676470588235293%\" colspan=\"3\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eTime 1\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"22.205882352941178%\" colspan=\"3\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eTime 2\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"22.205882352941178%\" colspan=\"3\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eTime 3\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"31.91176470588235%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eMean\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003eSD\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003eN\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eMean\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003eSD\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003eN\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eMean\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003eSD\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.323529411764706%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003eN\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"31.91176470588235%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003eEndoOnly\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003e\u0026nbsp;\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003e\u0026nbsp;\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003e\u0026nbsp;\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003e\u0026nbsp;\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003e\u0026nbsp;\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.323529411764706%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003e\u0026nbsp;\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"31.91176470588235%\" valign=\"top\"\u003e\n \u003cp\u003ePhysical health (WQoL-Ph)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e51.55\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e16.86\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e345\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e55.20\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e20.01\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e98\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e53.22\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e18.16\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.323529411764706%\" valign=\"top\"\u003e\n \u003cp\u003e63\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"31.91176470588235%\" valign=\"top\"\u003e\n \u003cp\u003ePsychological health (WQoL-Ps)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e50.81\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e16.39\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e345\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e51.95\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e18.13\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e98\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e51.52\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e16.32\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.323529411764706%\" valign=\"top\"\u003e\n \u003cp\u003e63\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"31.91176470588235%\" valign=\"top\"\u003e\n \u003cp\u003eSocial relationships (WQoL-SR)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e55.97\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e21.64\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e345\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e58.92\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e21.19\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e98\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e58.25\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e17.35\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.323529411764706%\" valign=\"top\"\u003e\n \u003cp\u003e63\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"31.91176470588235%\" valign=\"top\"\u003e\n \u003cp\u003eEnvironmental health (WQoL-E)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e66.74\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e15.95\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e346\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e70.61\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e16.30\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e98\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e70.38\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e15.43\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.323529411764706%\" valign=\"top\"\u003e\n \u003cp\u003e63\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"31.91176470588235%\" valign=\"top\"\u003e\n \u003cp\u003eStress (DASS-S)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e18.55\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e9.39\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e350\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e17.65\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e10.88\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e102\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e18.31\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e10.34\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.323529411764706%\" valign=\"top\"\u003e\n \u003cp\u003e59\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"31.91176470588235%\" valign=\"top\"\u003e\n \u003cp\u003eDepression (DASS-S)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e13.16\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e10.53\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e350\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e12.65\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e11.05\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e102\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e12.71\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e9.89\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.323529411764706%\" valign=\"top\"\u003e\n \u003cp\u003e59\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"31.91176470588235%\" valign=\"top\"\u003e\n \u003cp\u003eAnxiety (DASS-A)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e10.77\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e9.01\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e350\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e9.82\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e9.02\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e102\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e10.03\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e7.95\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.323529411764706%\" valign=\"top\"\u003e\n \u003cp\u003e59\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"31.91176470588235%\" valign=\"top\"\u003e\n \u003cp\u003eTotal distress (DASS-T)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e42.48\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e25.77\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e350\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e40.12\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e27.84\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e102\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e41.05\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e24.61\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.323529411764706%\" valign=\"top\"\u003e\n \u003cp\u003e59\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"31.91176470588235%\" valign=\"top\"\u003e\n \u003cp\u003ePain severity (NSR)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e7.70\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e1.72\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e352\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e6.99\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e1.98\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e107\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e6.89\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e1.82\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.323529411764706%\" valign=\"top\"\u003e\n \u003cp\u003e66\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"31.91176470588235%\" valign=\"top\"\u003e\n \u003cp\u003eFunctional pain disability (BPI)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e4.29\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e2.49\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e345\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e3.80\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e2.74\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e96\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e3.80\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e2.74\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.323529411764706%\" valign=\"top\"\u003e\n \u003cp\u003e59\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"31.91176470588235%\" valign=\"top\"\u003e\n \u003cp\u003eHelplessness (PCS-H)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e13.65\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e5.79\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e352\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e11.55\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e5.88\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e103\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e8.88\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e6.09\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.323529411764706%\" valign=\"top\"\u003e\n \u003cp\u003e59\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"31.91176470588235%\" valign=\"top\"\u003e\n \u003cp\u003eMagnification (PCS-M)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e5.91\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e3.05\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e351\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e4.84\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e3.29\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e103\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e4.46\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e3.42\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.323529411764706%\" valign=\"top\"\u003e\n \u003cp\u003e59\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"31.91176470588235%\" valign=\"top\"\u003e\n \u003cp\u003eRumination (PCS-M)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e10.70\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e4.22\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e350\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e8.03\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e4.29\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e103\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e6.31\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e4.25\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.323529411764706%\" valign=\"top\"\u003e\n \u003cp\u003e59\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"31.91176470588235%\" valign=\"top\"\u003e\n \u003cp\u003eTotal pain catastrophising (PCS-T)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e30.25\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e11.61\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e350\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e24.43\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e12.46\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e103\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e19.64\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e12.60\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.323529411764706%\" valign=\"top\"\u003e\n \u003cp\u003e59\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"31.91176470588235%\" valign=\"top\"\u003e\n \u003cp\u003eFatigue (FSI)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e34.99\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e15.88\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e347\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e25.31\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e16.65\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e89\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e32.53\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e16.43\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.323529411764706%\" valign=\"top\"\u003e\n \u003cp\u003e59\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"31.91176470588235%\" valign=\"top\"\u003e\n \u003cp\u003eMenstrual symptoms (MSS)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e50.10\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e15.14\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e346\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e50.50\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e18.68\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e105\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e48.24\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e17.68\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.323529411764706%\" valign=\"top\"\u003e\n \u003cp\u003e66\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"31.91176470588235%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003eEndo+IBS\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.323529411764706%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"31.91176470588235%\" valign=\"top\"\u003e\n \u003cp\u003ePhysical health (WQoL-Ph)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e47.82\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e18.88\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e256\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e50.42\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e18.30\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e76\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e48.00\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e19.35\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.323529411764706%\" valign=\"top\"\u003e\n \u003cp\u003e52\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"31.91176470588235%\" valign=\"top\"\u003e\n \u003cp\u003ePsychological health (WQoL-Ps)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e46.67\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e18.43\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e256\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e48.79\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e20.16\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e76\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e47.79\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e18.83\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.323529411764706%\" valign=\"top\"\u003e\n \u003cp\u003e52\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"31.91176470588235%\" valign=\"top\"\u003e\n \u003cp\u003eSocial relationships (WQoL-SR)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e51.20\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e24.10\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e256\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e49.16\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e20.84\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e76\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e54.21\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e23.27\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.323529411764706%\" valign=\"top\"\u003e\n \u003cp\u003e52\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"31.91176470588235%\" valign=\"top\"\u003e\n \u003cp\u003eEnvironmental health (WQoL-E)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e64.21\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e17.96\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e256\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e66.09\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e14.12\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e76\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e65.96\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e19.42\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.323529411764706%\" valign=\"top\"\u003e\n \u003cp\u003e52\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"31.91176470588235%\" valign=\"top\"\u003e\n \u003cp\u003eStress (DASS-S)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e19.66\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e9.98\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e257\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e16.38\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e9.09\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e78\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e17.92\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e8.91\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.323529411764706%\" valign=\"top\"\u003e\n \u003cp\u003e50\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"31.91176470588235%\" valign=\"top\"\u003e\n \u003cp\u003eDepression (DASS-S)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e15.12\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e11.37\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e256\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e13.38\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e11.25\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e78\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e14.64\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e10.73\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.323529411764706%\" valign=\"top\"\u003e\n \u003cp\u003e50\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"31.91176470588235%\" valign=\"top\"\u003e\n \u003cp\u003eAnxiety (DASS-A)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e12.58\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e9.37\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e257\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e8.92\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e7.89\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e78\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e11.04\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e9.19\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.323529411764706%\" valign=\"top\"\u003e\n \u003cp\u003e50\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"31.91176470588235%\" valign=\"top\"\u003e\n \u003cp\u003eTotal distress (DASS-T)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e47.44\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e26.73\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e256\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e38.69\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e24.30\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e78\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e43.60\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e24.33\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.323529411764706%\" valign=\"top\"\u003e\n \u003cp\u003e50\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"31.91176470588235%\" valign=\"top\"\u003e\n \u003cp\u003ePain severity (NSR)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e7.85\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e1.49\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e258\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e7.33\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e1.72\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e81\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e6.98\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e1.63\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.323529411764706%\" valign=\"top\"\u003e\n \u003cp\u003e52\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"31.91176470588235%\" valign=\"top\"\u003e\n \u003cp\u003eFunctional pain disability (BPI)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e4.76\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e2.50\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e256\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e4.21\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e2.77\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e75\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e4.66\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e2.83\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.323529411764706%\" valign=\"top\"\u003e\n \u003cp\u003e45\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"31.91176470588235%\" valign=\"top\"\u003e\n \u003cp\u003eHelplessness (PCS-H)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e13.75\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e5.42\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e256\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e11.40\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e4.96\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e80\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e9.27\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e5.67\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.323529411764706%\" valign=\"top\"\u003e\n \u003cp\u003e48\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"31.91176470588235%\" valign=\"top\"\u003e\n \u003cp\u003eMagnification (PCS-M)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e6.19\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e3.14\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e256\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e5.33\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e2.80\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e80\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e5.08\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e3.38\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.323529411764706%\" valign=\"top\"\u003e\n \u003cp\u003e48\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"31.91176470588235%\" valign=\"top\"\u003e\n \u003cp\u003eRumination (PCS-M)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e11.09\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e3.88\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e256\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e8.13\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e3.81\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e80\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e7.88\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e4.50\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.323529411764706%\" valign=\"top\"\u003e\n \u003cp\u003e48\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"31.91176470588235%\" valign=\"top\"\u003e\n \u003cp\u003eTotal pain catastrophising (PCS-T)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e31.04\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e11.23\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e256\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e24.85\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e10.23\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e80\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e22.23\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e12.54\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.323529411764706%\" valign=\"top\"\u003e\n \u003cp\u003e48\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"31.91176470588235%\" valign=\"top\"\u003e\n \u003cp\u003eFatigue (FSI)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e36.71\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e16.28\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e257\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e27.99\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e14.92\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e72\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e36.31\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e16.41\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.323529411764706%\" valign=\"top\"\u003e\n \u003cp\u003e49\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"31.91176470588235%\" valign=\"top\"\u003e\n \u003cp\u003eMenstrual Symptoms (MSS)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e55.51\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e13.14\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e257\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e54.58\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.647058823529412%\" valign=\"top\"\u003e\n \u003cp\u003e13.07\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.205882352941177%\" valign=\"top\"\u003e\n \u003cp\u003e81\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.235294117647058%\" valign=\"top\"\u003e\n \u003cp\u003e51.33\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.794117647058823%\" valign=\"top\"\u003e\n \u003cp\u003e15.36\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.323529411764706%\" valign=\"top\"\u003e\n \u003cp\u003e52\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eM\u003c/em\u003e = mean, \u003cem\u003eSD\u003c/em\u003e = standard deviation, \u003cem\u003eN\u003c/em\u003e = number of participants\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMain Analysis\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNo significant main effects, interactions, or simple effects for environmental HRQoL was observed. The omnibus and parameter estimates for the included covariates demonstrated significant associations between age and all outcomes, except for social HRQoL (\u003cem\u003ep\u003c/em\u003e = 0.946), and environmental HRQoL (\u003cem\u003ep\u003c/em\u003e =0.191) with older participants reporting better outcomes than younger participants. Higher BMI was significantly associated with lower physical (\u003cem\u003eB\u003c/em\u003e = -0.52, \u003cem\u003et\u003c/em\u003e = -3.57,\u003cem\u003e\u0026nbsp;p\u003c/em\u003e\u0026lt;\u0026thinsp;.001), psychological (\u003cem\u003eB\u003c/em\u003e = -0.46, \u003cem\u003et\u003c/em\u003e = -3.34,\u003cem\u003e\u0026nbsp;p\u003c/em\u003e\u0026lt;\u0026thinsp;.001), and environmental (\u003cem\u003eB\u003c/em\u003e = -0.43, \u003cem\u003et\u003c/em\u003e = -3.10,\u003cem\u003e\u0026nbsp;p\u003c/em\u003e=\u0026thinsp;.002) HRQoL. Contraceptive pill usage and age of menarche were not significantly associated with any outcome variable.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTable 3\u003c/strong\u003e presents the omnibus tests fixed effects for group, time, and group*time interactions (covariates not reported) for each outcome. \u003cstrong\u003eTable 4\u003c/strong\u003e contains the parameter estimates for the same. A significant quadratic group*time interaction for rumination was found, suggesting that changes in rumination scores over time significantly differed depending on group membership (EndoOnly or Endo+IBS). Examination of the parameter estimates also revealed small to moderate significant quadratic group*time interactions for total pain catastrophising and social HRQoL. No other interaction effects were observed.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTable 3\u003c/strong\u003e - Fixed Effect Omnibus for Group, Time, and Group*Time (Excluding Covariates)\u003c/p\u003e\n\u003ctable border=\"0\" cellspacing=\"0\" cellpadding=\"0\" width=\"973\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd width=\"21.333333333333332%\" valign=\"bottom\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\" valign=\"bottom\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.153846153846154%\" valign=\"bottom\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"22.871794871794872%\" colspan=\"4\"\u003e\n \u003cp\u003e\u003cstrong\u003eGroup\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"22.871794871794872%\" colspan=\"4\"\u003e\n \u003cp\u003e\u003cstrong\u003eTime\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"21.025641025641026%\" colspan=\"5\" valign=\"bottom\"\u003e\n \u003cp\u003e\u003cstrong\u003eGroup*Time\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"21.333333333333332%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003eR\u003csup\u003e2\u003c/sup\u003eM\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.153846153846154%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003eR\u003csup\u003e2\u003c/sup\u003eC\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.923076923076923%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003eF\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003eNum df\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.333333333333333%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003eDen df\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.871794871794871%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003ep\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.923076923076923%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003eF\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003eNum df\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.333333333333333%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003eDen df\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.871794871794871%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003ep\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.923076923076923%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003eF\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003eNum df\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.333333333333333%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003eDen df\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.512820512820513%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003ep\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"0.5128205128205128%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"21.333333333333332%\"\u003e\n \u003cp\u003ePhysical health (WQoL-Ph)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e0.08\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.153846153846154%\"\u003e\n \u003cp\u003e0.59\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.923076923076923%\"\u003e\n \u003cp\u003e4.92\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.333333333333333%\"\u003e\n \u003cp\u003e424\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.871794871794871%\"\u003e\n \u003cp\u003e\u003cstrong\u003e0.027\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.923076923076923%\"\u003e\n \u003cp\u003e1.91\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.333333333333333%\"\u003e\n \u003cp\u003e225\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.871794871794871%\"\u003e\n \u003cp\u003e0.151\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.923076923076923%\"\u003e\n \u003cp\u003e0.13\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.333333333333333%\"\u003e\n \u003cp\u003e225\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.512820512820513%\"\u003e\n \u003cp\u003e0.882\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"0.5128205128205128%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"21.333333333333332%\"\u003e\n \u003cp\u003ePsychological health (WQoL-Ps)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e0.07\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.153846153846154%\"\u003e\n \u003cp\u003e0.61\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.923076923076923%\"\u003e\n \u003cp\u003e5.59\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.333333333333333%\"\u003e\n \u003cp\u003e422\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.871794871794871%\"\u003e\n \u003cp\u003e\u003cstrong\u003e0.019\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.923076923076923%\"\u003e\n \u003cp\u003e1.29\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.333333333333333%\"\u003e\n \u003cp\u003e213\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.871794871794871%\"\u003e\n \u003cp\u003e0.276\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.923076923076923%\"\u003e\n \u003cp\u003e0.83\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.333333333333333%\"\u003e\n \u003cp\u003e212\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.512820512820513%\"\u003e\n \u003cp\u003e0.439\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"0.5128205128205128%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"21.333333333333332%\"\u003e\n \u003cp\u003eSocial relationships (WQoL-SR)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e0.03\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.153846153846154%\"\u003e\n \u003cp\u003e0.53\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.923076923076923%\"\u003e\n \u003cp\u003e5.48\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.333333333333333%\"\u003e\n \u003cp\u003e417\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.871794871794871%\"\u003e\n \u003cp\u003e\u003cstrong\u003e0.02\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.923076923076923%\"\u003e\n \u003cp\u003e0.42\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.333333333333333%\"\u003e\n \u003cp\u003e223\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.871794871794871%\"\u003e\n \u003cp\u003e0.657\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.923076923076923%\"\u003e\n \u003cp\u003e2.76\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.333333333333333%\"\u003e\n \u003cp\u003e223\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.512820512820513%\"\u003e\n \u003cp\u003e0.066\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"0.5128205128205128%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"21.333333333333332%\"\u003e\n \u003cp\u003eEnvironmental health (WQoL-E)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e0.04\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.153846153846154%\"\u003e\n \u003cp\u003e0.73\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.923076923076923%\"\u003e\n \u003cp\u003e2.38\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.333333333333333%\"\u003e\n \u003cp\u003e422\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.871794871794871%\"\u003e\n \u003cp\u003e0.124\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.923076923076923%\"\u003e\n \u003cp\u003e0.03\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.333333333333333%\"\u003e\n \u003cp\u003e191\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.871794871794871%\"\u003e\n \u003cp\u003e0.966\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.923076923076923%\"\u003e\n \u003cp\u003e0.34\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.333333333333333%\"\u003e\n \u003cp\u003e191\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.512820512820513%\"\u003e\n \u003cp\u003e0.712\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"0.5128205128205128%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"21.333333333333332%\"\u003e\n \u003cp\u003eDepression (DASS-S)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e0.07\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.153846153846154%\"\u003e\n \u003cp\u003e0.65\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.923076923076923%\"\u003e\n \u003cp\u003e3.48\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.333333333333333%\"\u003e\n \u003cp\u003e427\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.871794871794871%\"\u003e\n \u003cp\u003e0.063\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.923076923076923%\"\u003e\n \u003cp\u003e4.58\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.333333333333333%\"\u003e\n \u003cp\u003e197\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.871794871794871%\"\u003e\n \u003cp\u003e\u003cstrong\u003e0.011\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.923076923076923%\"\u003e\n \u003cp\u003e0.32\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.333333333333333%\"\u003e\n \u003cp\u003e197\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.512820512820513%\"\u003e\n \u003cp\u003e0.727\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"0.5128205128205128%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"21.333333333333332%\"\u003e\n \u003cp\u003eAnxiety (DASS-A)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e0.10\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.153846153846154%\"\u003e\n \u003cp\u003e0.65\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.923076923076923%\"\u003e\n \u003cp\u003e1.45\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.333333333333333%\"\u003e\n \u003cp\u003e430\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.871794871794871%\"\u003e\n \u003cp\u003e0.229\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.923076923076923%\"\u003e\n \u003cp\u003e6.47\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.333333333333333%\"\u003e\n \u003cp\u003e205\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.871794871794871%\"\u003e\n \u003cp\u003e\u003cstrong\u003e0.002\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.923076923076923%\"\u003e\n \u003cp\u003e1.96\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.333333333333333%\"\u003e\n \u003cp\u003e205\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.512820512820513%\"\u003e\n \u003cp\u003e0.144\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"0.5128205128205128%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"21.333333333333332%\"\u003e\n \u003cp\u003eStress (DASS-S)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e0.08\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.153846153846154%\"\u003e\n \u003cp\u003e0.55\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.923076923076923%\"\u003e\n \u003cp\u003e0.00\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.333333333333333%\"\u003e\n \u003cp\u003e422\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.871794871794871%\"\u003e\n \u003cp\u003e0.960\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.923076923076923%\"\u003e\n \u003cp\u003e6.40\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.333333333333333%\"\u003e\n \u003cp\u003e220\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.871794871794871%\"\u003e\n \u003cp\u003e\u003cstrong\u003e0.002\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.923076923076923%\"\u003e\n \u003cp\u003e0.45\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.333333333333333%\"\u003e\n \u003cp\u003e220\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.512820512820513%\"\u003e\n \u003cp\u003e0.636\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"0.5128205128205128%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"21.333333333333332%\"\u003e\n \u003cp\u003eTotal distress (DASS-T)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e0.10\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.153846153846154%\"\u003e\n \u003cp\u003e0.64\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.923076923076923%\"\u003e\n \u003cp\u003e1.62\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.333333333333333%\"\u003e\n \u003cp\u003e426\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.871794871794871%\"\u003e\n \u003cp\u003e0.203\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.923076923076923%\"\u003e\n \u003cp\u003e7.41\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.333333333333333%\"\u003e\n \u003cp\u003e200\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.871794871794871%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026lt;\u0026thinsp;.001\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.923076923076923%\"\u003e\n \u003cp\u003e0.77\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.333333333333333%\"\u003e\n \u003cp\u003e200\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.512820512820513%\"\u003e\n \u003cp\u003e0.463\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"0.5128205128205128%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"21.333333333333332%\"\u003e\n \u003cp\u003ePain severity (NRS)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e0.08\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.153846153846154%\"\u003e\n \u003cp\u003e0.53\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.923076923076923%\"\u003e\n \u003cp\u003e0.32\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.333333333333333%\"\u003e\n \u003cp\u003e420\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.871794871794871%\"\u003e\n \u003cp\u003e0.573\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.923076923076923%\"\u003e\n \u003cp\u003e19.97\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.333333333333333%\"\u003e\n \u003cp\u003e253\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.871794871794871%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026lt;\u0026thinsp;.001\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.923076923076923%\"\u003e\n \u003cp\u003e0.56\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.333333333333333%\"\u003e\n \u003cp\u003e253\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.512820512820513%\"\u003e\n \u003cp\u003e0.571\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"0.5128205128205128%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"21.333333333333332%\"\u003e\n \u003cp\u003eFunctional pain disability (BPI)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e0.05\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.153846153846154%\"\u003e\n \u003cp\u003e0.46\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.923076923076923%\"\u003e\n \u003cp\u003e3.90\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.333333333333333%\"\u003e\n \u003cp\u003e417\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.871794871794871%\"\u003e\n \u003cp\u003e\u003cstrong\u003e0.049\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.923076923076923%\"\u003e\n \u003cp\u003e2.18\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.333333333333333%\"\u003e\n \u003cp\u003e234\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.871794871794871%\"\u003e\n \u003cp\u003e0.115\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.923076923076923%\"\u003e\n \u003cp\u003e0.08\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.333333333333333%\"\u003e\n \u003cp\u003e233\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.512820512820513%\"\u003e\n \u003cp\u003e0.923\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"0.5128205128205128%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"21.333333333333332%\"\u003e\n \u003cp\u003eHelplessness (PCS-H)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e0.15\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.153846153846154%\"\u003e\n \u003cp\u003e0.62\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.923076923076923%\"\u003e\n \u003cp\u003e0.00\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.333333333333333%\"\u003e\n \u003cp\u003e426\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.871794871794871%\"\u003e\n \u003cp\u003e0.952\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.923076923076923%\"\u003e\n \u003cp\u003e20.06\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.333333333333333%\"\u003e\n \u003cp\u003e210\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.871794871794871%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026lt;\u0026thinsp;.001\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.923076923076923%\"\u003e\n \u003cp\u003e1.09\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.333333333333333%\"\u003e\n \u003cp\u003e210\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.512820512820513%\"\u003e\n \u003cp\u003e0.337\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"0.5128205128205128%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"21.333333333333332%\"\u003e\n \u003cp\u003eMagnification (PCS-M)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e0.11\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.153846153846154%\"\u003e\n \u003cp\u003e0.48\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.923076923076923%\"\u003e\n \u003cp\u003e0.72\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.333333333333333%\"\u003e\n \u003cp\u003e411\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.871794871794871%\"\u003e\n \u003cp\u003e0.395\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.923076923076923%\"\u003e\n \u003cp\u003e6.55\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.333333333333333%\"\u003e\n \u003cp\u003e255\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.871794871794871%\"\u003e\n \u003cp\u003e\u003cstrong\u003e0.002\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.923076923076923%\"\u003e\n \u003cp\u003e1.23\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.333333333333333%\"\u003e\n \u003cp\u003e254\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.512820512820513%\"\u003e\n \u003cp\u003e0.294\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"0.5128205128205128%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"21.333333333333332%\"\u003e\n \u003cp\u003eRumination (PCS-R)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e0.17\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.153846153846154%\"\u003e\n \u003cp\u003e0.60\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.923076923076923%\"\u003e\n \u003cp\u003e0.34\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.333333333333333%\"\u003e\n \u003cp\u003e421\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.871794871794871%\"\u003e\n \u003cp\u003e0.561\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.923076923076923%\"\u003e\n \u003cp\u003e41.02\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.333333333333333%\"\u003e\n \u003cp\u003e215\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.871794871794871%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026lt;\u0026thinsp;.001\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.923076923076923%\"\u003e\n \u003cp\u003e4.99\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.333333333333333%\"\u003e\n \u003cp\u003e215\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.512820512820513%\"\u003e\n \u003cp\u003e\u003cstrong\u003e0.008\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"0.5128205128205128%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"21.333333333333332%\"\u003e\n \u003cp\u003eTotal pain catastrophising (PCS-T)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e0.17\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.153846153846154%\"\u003e\n \u003cp\u003e0.64\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.923076923076923%\"\u003e\n \u003cp\u003e0.26\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.333333333333333%\"\u003e\n \u003cp\u003e428\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.871794871794871%\"\u003e\n \u003cp\u003e0.608\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.923076923076923%\"\u003e\n \u003cp\u003e28.91\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.333333333333333%\"\u003e\n \u003cp\u003e210\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.871794871794871%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026lt;\u0026thinsp;.001\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.923076923076923%\"\u003e\n \u003cp\u003e2.93\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.333333333333333%\"\u003e\n \u003cp\u003e210\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.512820512820513%\"\u003e\n \u003cp\u003e0.056\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"0.5128205128205128%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"21.333333333333332%\"\u003e\n \u003cp\u003eFatigue (FSI)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e0.10\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.153846153846154%\"\u003e\n \u003cp\u003e0.61\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.923076923076923%\"\u003e\n \u003cp\u003e7.05\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.333333333333333%\"\u003e\n \u003cp\u003e430\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.871794871794871%\"\u003e\n \u003cp\u003e\u003cstrong\u003e0.008\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.923076923076923%\"\u003e\n \u003cp\u003e17.11\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.333333333333333%\"\u003e\n \u003cp\u003e202\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.871794871794871%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026lt;\u0026thinsp;.001\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.923076923076923%\"\u003e\n \u003cp\u003e1.63\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.333333333333333%\"\u003e\n \u003cp\u003e202\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.512820512820513%\"\u003e\n \u003cp\u003e0.199\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"0.5128205128205128%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"21.333333333333332%\"\u003e\n \u003cp\u003eMenstrual Symptoms (MSS)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e0.06\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.153846153846154%\"\u003e\n \u003cp\u003e0.59\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.923076923076923%\"\u003e\n \u003cp\u003e5.77\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.333333333333333%\"\u003e\n \u003cp\u003e423\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.871794871794871%\"\u003e\n \u003cp\u003e\u003cstrong\u003e0.017\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.923076923076923%\"\u003e\n \u003cp\u003e0.04\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.333333333333333%\"\u003e\n \u003cp\u003e231\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.871794871794871%\"\u003e\n \u003cp\u003e0.965\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.923076923076923%\"\u003e\n \u003cp\u003e0.37\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.743589743589744%\"\u003e\n \u003cp\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.333333333333333%\"\u003e\n \u003cp\u003e231\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.512820512820513%\"\u003e\n \u003cp\u003e0.689\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"0.5128205128205128%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e\u003cem\u003eR\u003csup\u003e2\u003c/sup\u003eM\u003c/em\u003e = R-squared marginal estimates variance explained by the fixed effects, \u003cem\u003eR\u003csup\u003e2\u003c/sup\u003eC\u003c/em\u003e = R-squared conditional estimates the fraction explained by the fixed and random effects, \u003cem\u003eF\u003c/em\u003e\u0026thinsp;= F-statistic,\u0026thinsp; \u003cem\u003ep\u003c/em\u003e\u0026thinsp;=\u0026thinsp;test of significance, two-tailed with a threshold of\u0026thinsp;\u0026lt;\u0026thinsp;0.05, 95% confidence interval. Measure abbreviations: WQoL-Ph: World Health Organisation Quality of Life Assessment (WHOQOL-BREF)-physical health subscale; WQoL-Ps: WHOQOL-BREF-psychological health subscale; WQoL-SR: WHOQOL-BREF-social relationships subscale: WQoL-E: WHOQOL-BREF-environment subscale: DASS-A: Depression Anxiety and Stress Scale\u0026ndash;anxiety subscale; DASS-D: Depression Anxiety and Stress Scale\u0026ndash;depression subscale; DASS-S: Depression Anxiety and Stress Scale\u0026ndash;stress subscale; DASS-T: Depression Anxiety and Stress Scale\u0026ndash;Total; NRS: Pain Numerical Response Scale; BPI: Brief Pain Inventory PCS-H: Pain Catastrophizing Scale\u0026ndash;helplessness subscale; PCS-M: Pain Catastrophizing Scale\u0026ndash;magnification subscale; PCS-R: Pain Catastrophizing Scale-rumination subscale; FSI: Fatigue Symptom Inventory; MSS: Menstrual Symptom Scale.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTable 4\u003c/strong\u003e \u0026ndash; Parameter Estimates for Fixed Effects - Group, Time, and Group*Time (excluding covariates)\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003ctable border=\"0\" cellspacing=\"0\" cellpadding=\"0\" width=\"703\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd width=\"11.2375533428165%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.517780938833571%\" colspan=\"2\"\u003e\n \u003cp\u003e\u003cstrong\u003eWQoL-Ph\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.547652916073969%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.832147937411095%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.241820768136558%\" colspan=\"2\"\u003e\n \u003cp\u003e\u003cstrong\u003eWQoL-Ps\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.547652916073969%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.832147937411095%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.241820768136558%\" colspan=\"2\"\u003e\n \u003cp\u003e\u003cstrong\u003eWQoL-SR\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.547652916073969%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.832147937411095%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.241820768136558%\" colspan=\"2\"\u003e\n \u003cp\u003e\u003cstrong\u003eWQoL - E\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.547652916073969%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.832147937411095%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"11.253561253561253%\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd width=\"7.6923076923076925%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003eB\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003eSE\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003et\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003ep\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003eB\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003eSE\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003et\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003ep\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003eB\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003eSE\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003et\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003ep\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003eB\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003eSE\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003et\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003ep\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"11.253561253561253%\"\u003e\n \u003cp\u003e(Intercept)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.6923076923076925%\"\u003e\n \u003cp\u003e51.37\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e1.08\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e47.58\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e\u0026lt;\u0026thinsp;.001\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e48.95\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e1.03\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e47.60\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e\u0026lt;\u0026thinsp;.001\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e54.04\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e1.38\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e39.06\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e\u0026lt;\u0026thinsp;.001\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e66.08\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e1.01\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e65.76\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e\u0026lt;\u0026thinsp;.001\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"11.253561253561253%\"\u003e\n \u003cp\u003eGroup\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.6923076923076925%\"\u003e\n \u003cp\u003e4.80\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e2.17\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e2.22\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e\u003cstrong\u003e0.027\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e4.88\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e2.06\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e2.36\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e\u003cstrong\u003e0.019\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e6.49\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e2.77\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e2.34\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e\u003cstrong\u003e0.020\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e3.11\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e2.02\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e1.54\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e0.124\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"11.253561253561253%\"\u003e\n \u003cp\u003eTime (linear)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.6923076923076925%\"\u003e\n \u003cp\u003e0.43\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e1.23\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e0.35\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e0.726\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-1.58\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e1.14\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-1.38\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e0.168\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e1.22\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e1.63\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e0.75\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e0.454\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-0.12\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e0.96\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-0.12\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e0.902\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"11.253561253561253%\"\u003e\n \u003cp\u003eTime (quadratic)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.6923076923076925%\"\u003e\n \u003cp\u003e-2.33\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e1.34\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-1.74\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e0.083\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-1.45\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e1.23\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-1.18\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e0.24\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e1.27\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e1.77\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e0.72\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e0.471\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-0.27\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e1.03\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-0.26\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e0.796\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"11.253561253561253%\"\u003e\n \u003cp\u003eGroup *Time (linear)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.6923076923076925%\"\u003e\n \u003cp\u003e-1.01\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e2.46\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-0.41\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e0.683\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e1.32\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e2.28\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e0.58\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e0.563\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-3.82\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e3.25\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-1.17\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e0.242\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-1.47\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e1.91\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-0.77\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e0.444\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"11.253561253561253%\"\u003e\n \u003cp\u003eGroup *Time (quadratic)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.6923076923076925%\"\u003e\n \u003cp\u003e0.43\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e2.67\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e0.16\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e0.873\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e3.12\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e2.47\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e1.27\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e0.207\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-8.07\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e3.53\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-2.29\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e\u003cstrong\u003e0.023\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-1.03\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e2.06\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-0.50\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e0.617\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"11.2375533428165%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.517780938833571%\" colspan=\"2\"\u003e\n \u003cp\u003e\u003cstrong\u003eDASS-D\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.547652916073969%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.832147937411095%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.241820768136558%\" colspan=\"2\"\u003e\n \u003cp\u003e\u003cstrong\u003eDASS-A\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.547652916073969%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.832147937411095%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.241820768136558%\" colspan=\"2\"\u003e\n \u003cp\u003e\u003cstrong\u003eDASS-S\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.547652916073969%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.832147937411095%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.241820768136558%\" colspan=\"2\"\u003e\n \u003cp\u003e\u003cstrong\u003eDASS-T\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.547652916073969%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.832147937411095%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"11.253561253561253%\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd width=\"7.6923076923076925%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003eB\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003eSE\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003et\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003ep\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003eB\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003eSE\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003et\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003ep\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003eB\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003eSE\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003et\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003ep\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003eB\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003eSE\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003et\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003ep\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"11.253561253561253%\"\u003e\n \u003cp\u003e(Intercept)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.6923076923076925%\"\u003e\n \u003cp\u003e13.23\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e0.63\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e20.95\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e\u0026lt;\u0026thinsp;.001\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e10.43\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e0.51\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e20.46\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e\u0026lt;\u0026thinsp;.001\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e17.43\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e0.59\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e29.76\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e\u0026lt;\u0026thinsp;.001\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e41.13\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e1.51\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e27.28\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e\u0026lt;\u0026thinsp;.001\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"11.253561253561253%\"\u003e\n \u003cp\u003eGroup\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.6923076923076925%\"\u003e\n \u003cp\u003e-2.36\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e1.27\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-1.86\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e0.063\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-1.23\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e1.02\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-1.21\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e0.229\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e0.06\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e1.17\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e0.05\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e0.96\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-3.85\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e3.02\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-1.27\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e0.203\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"11.253561253561253%\"\u003e\n \u003cp\u003eTime (linear)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.6923076923076925%\"\u003e\n \u003cp\u003e1.19\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e0.69\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e1.72\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e0.087\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e0.88\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e0.57\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e1.55\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e0.123\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-0.03\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e0.70\u003c/p\u003e\n \u003c/td\u003e\n 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\u003cp\u003e2.89\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e\u003cstrong\u003e0.004\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e2.08\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e0.59\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e3.56\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026lt;\u0026thinsp;.001\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e2.48\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e0.73\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e3.39\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026lt;\u0026thinsp;.001\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e6.67\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e1.73\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e3.85\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026lt;\u0026thinsp;.001\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"11.253561253561253%\"\u003e\n \u003cp\u003eGroup *Time (linear)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.6923076923076925%\"\u003e\n \u003cp\u003e-0.79\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e1.38\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-0.57\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e0.567\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-0.13\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e1.13\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-0.11\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e0.912\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e0.36\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e1.41\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e0.25\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e0.799\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-0.74\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e3.36\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-0.22\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e0.826\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"11.253561253561253%\"\u003e\n \u003cp\u003eGroup *Time (quadratic)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.6923076923076925%\"\u003e\n \u003cp\u003e-1.00\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e1.42\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-0.70\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e0.484\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-2.24\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n 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width=\"5.832147937411095%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.241820768136558%\" colspan=\"2\"\u003e\n \u003cp\u003e\u003cstrong\u003eFSI\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.547652916073969%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.832147937411095%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.241820768136558%\" colspan=\"2\"\u003e\n \u003cp\u003e\u003cstrong\u003eMSS\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.547652916073969%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.832147937411095%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n 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width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-4.31\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e1.79\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-2.40\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e\u003cstrong\u003e0.017\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"11.253561253561253%\"\u003e\n \u003cp\u003eTime (linear)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.6923076923076925%\"\u003e\n \u003cp\u003e-0.45\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e0.11\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-4.01\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026lt;\u0026thinsp;.001\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-0.11\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e0.21\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-0.51\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e0.608\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-0.62\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e1.11\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-0.56\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e0.578\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-0.15\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e1.01\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-0.15\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e0.883\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"11.253561253561253%\"\u003e\n \u003cp\u003eTime (quadratic)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.6923076923076925%\"\u003e\n \u003cp\u003e0.41\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e0.12\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e3.48\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026lt;\u0026thinsp;.001\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e0.38\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e0.22\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e1.75\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e0.082\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e6.44\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e1.19\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e5.40\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026lt;\u0026thinsp;.001\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e0.18\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e1.06\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e0.17\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e0.865\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"11.253561253561253%\"\u003e\n \u003cp\u003eGroup *Time (linear)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.6923076923076925%\"\u003e\n \u003cp\u003e0.09\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e0.23\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e0.39\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e0.699\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-0.12\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e0.41\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-0.29\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e0.774\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-3.94\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e2.22\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-1.78\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e0.077\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-0.38\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e2.03\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-0.19\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e0.853\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"11.253561253561253%\"\u003e\n \u003cp\u003eGroup *Time (quadratic)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.6923076923076925%\"\u003e\n \u003cp\u003e-0.19\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e0.24\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-0.83\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e0.409\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e0.07\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e0.44\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e0.17\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e0.864\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-0.51\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e2.39\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-0.22\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e0.83\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-1.82\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e2.11\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-0.86\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e0.39\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"11.2375533428165%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.517780938833571%\" colspan=\"2\"\u003e\n \u003cp\u003e\u003cstrong\u003ePCS-H\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.547652916073969%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.832147937411095%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.241820768136558%\" colspan=\"2\"\u003e\n \u003cp\u003e\u003cstrong\u003ePCS-M\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.547652916073969%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.832147937411095%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.241820768136558%\" colspan=\"2\"\u003e\n \u003cp\u003e\u003cstrong\u003ePCS-R\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.547652916073969%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.832147937411095%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"10.241820768136558%\" colspan=\"2\"\u003e\n \u003cp\u003e\u003cstrong\u003ePCS-T\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.547652916073969%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.832147937411095%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"11.253561253561253%\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd width=\"7.6923076923076925%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003eB\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003eSE\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003et\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003ep\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003eB\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003eSE\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003et\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003ep\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003eB\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003eSE\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003et\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003ep\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003eB\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003eSE\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003et\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003ep\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"11.253561253561253%\"\u003e\n \u003cp\u003e(Intercept)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.6923076923076925%\"\u003e\n \u003cp\u003e11.25\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e0.33\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e33.89\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e\u0026lt;\u0026thinsp;.001\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e5.16\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e0.18\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e28.02\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e\u0026lt;\u0026thinsp;.001\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e8.51\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e0.25\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e34.00\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e\u0026lt;\u0026thinsp;.001\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e24.91\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e0.68\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e36.65\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e\u0026lt;\u0026thinsp;.001\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"11.253561253561253%\"\u003e\n \u003cp\u003eGroup\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.6923076923076925%\"\u003e\n \u003cp\u003e-0.04\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e0.67\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-0.06\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e0.952\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-0.31\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e0.37\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-0.85\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e0.395\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-0.29\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e0.50\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-0.58\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e0.561\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-0.70\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e1.36\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-0.51\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e0.608\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"11.253561253561253%\"\u003e\n \u003cp\u003eTime (linear)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.6923076923076925%\"\u003e\n \u003cp\u003e-2.14\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e0.39\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-5.42\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026lt;\u0026thinsp;.001\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-0.41\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e0.24\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-1.68\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e0.094\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-2.14\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e0.31\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-6.96\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026lt;\u0026thinsp;.001\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-4.67\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e0.80\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-5.85\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026lt;\u0026thinsp;.001\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"11.253561253561253%\"\u003e\n \u003cp\u003eTime (quadratic)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.6923076923076925%\"\u003e\n \u003cp\u003e0.55\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e0.40\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e1.38\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e0.17\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e0.61\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e0.25\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e2.47\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e\u003cstrong\u003e0.014\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e1.01\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e0.31\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e3.24\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e\u003cstrong\u003e0.001\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e2.21\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e0.80\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e2.75\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e\u003cstrong\u003e0.007\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"11.253561253561253%\"\u003e\n \u003cp\u003eGroup *Time (linear)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.6923076923076925%\"\u003e\n \u003cp\u003e-0.59\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e0.79\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-0.75\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e0.454\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-0.39\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e0.48\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-0.81\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e0.416\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-0.61\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e0.61\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-0.99\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e0.325\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-1.66\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e1.59\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-1.04\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e0.301\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"11.253561253561253%\"\u003e\n \u003cp\u003eGroup *Time (quadratic)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.6923076923076925%\"\u003e\n \u003cp\u003e-1.15\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e0.80\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-1.45\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e0.149\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-0.76\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e0.49\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-1.53\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e0.126\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-1.96\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e0.62\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-3.16\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e\u003cstrong\u003e0.002\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-3.87\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"4.700854700854701%\"\u003e\n \u003cp\u003e1.61\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.555555555555555%\"\u003e\n \u003cp\u003e-2.40\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.84045584045584%\"\u003e\n \u003cp\u003e\u003cstrong\u003e0.017\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003cem\u003eB\u003c/em\u003e = fixed effects co-efficient, \u003cem\u003eSE\u003c/em\u003e = standard error, \u003cem\u003et\u0026nbsp;\u003c/em\u003e= t-test, \u003cem\u003ep\u003c/em\u003e\u0026thinsp;=\u0026thinsp;test of significance, two-tailed with a threshold of\u0026thinsp;\u0026lt;\u0026thinsp;0.05, 95% confidence interval. Measure abbreviations: WQoL-Ph: World Health Organisation Quality of Life Assessment (WHOQOL-BREF)-physical health subscale; WQoL-Ps: WHOQOL-BREF-psychological health subscale; WQoL-SR: WHOQOL-BREF-social relationships subscale: WQoL-E: WHOQOL-BREF-environment subscale: DASS-A: Depression Anxiety and Stress Scale\u0026ndash;anxiety subscale; DASS-D: Depression Anxiety and Stress Scale\u0026ndash;depression subscale; DASS-S: Depression Anxiety and Stress Scale\u0026ndash;stress subscale; DASS-T: Depression Anxiety and Stress Scale\u0026ndash;Total; NRS: Pain Numerical Response Scale; BPI: Brief Pain Inventory PCS-H: Pain Catastrophizing Scale\u0026ndash;helplessness subscale; PCS-M: Pain Catastrophizing Scale\u0026ndash;magnification subscale; PCS-R: Pain Catastrophizing Scale-rumination subscale; FSI: Fatigue Symptom Inventory; MSS: Menstrual Symptom Scale.\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eResults also showed significant main effects of group membership, with higher HRQoL (physical, psychological, and social), and lower functional pain disability, fatigue, and menstrual symptoms observed for the EndoOnly group across the study period. Significant main effects of time for psychological distress (symptoms of depression, anxiety, stress, and total distress), pain severity, pain catastrophising (helplessness, magnification, rumination, and total) and fatigue were also indicated. Findings suggested that average outcome levels significantly changed over time, regardless of group allocation.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTable 5\u003c/strong\u003e presents the simple effects of time parameter estimates for significant findings only. Despite observing a significant interaction, no simple effects of time for social HRQoL were found. Significant linear reductions in rumination, total pain catastrophising, pain severity\u003cem\u003e\u0026nbsp;\u003c/em\u003eand helplessness, were observed, with\u0026nbsp;effects generally stronger for the EndoOnly group.\u0026nbsp;Results also showed significant positive quadratic effects of time for pain severity in both groups, and for rumination and total pain catastrophising in the Endo+IBS group only. Findings suggested that whilst both groups showed significant reductions in outcome levels,\u003cem\u003e\u0026nbsp;\u003c/em\u003ethe rates of decline were not stable and tended to diminish, flatten out or change direction over time. In particular, trend findings for rumination and total pain catastrophising indicated that whilst individuals in the EndoOnly group consistently improved linearly, the rate of change in both outcomes for the Endo+IBS group was initially fast and steep (improvement in scores), but then diminished and rebounded between T2 to T3 (\u003cstrong\u003eFigure 1\u003c/strong\u003e).\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTable 5 \u0026ndash;\u0026nbsp;\u003c/strong\u003eSimple Effects of Time Parameter Estimates for Significant Outcomes Only\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n\u003ctable border=\"0\" cellspacing=\"0\" cellpadding=\"0\" width=\"624\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd width=\"19.74317817014446%\" valign=\"bottom\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"21.187800963081862%\"\u003e\n \u003cp\u003e\u003cstrong\u003eGroup\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e\u003cstrong\u003eContrast\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003eB\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003et\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003ep\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"19.74317817014446%\" valign=\"bottom\"\u003e\n \u003cp\u003e\u003cstrong\u003eDASS-D\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"21.187800963081862%\" valign=\"top\"\u003e\n \u003cp\u003eEndo+IBS\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003elinear\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e1.58\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e1.505\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e0.134\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"19.74317817014446%\" valign=\"bottom\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd width=\"21.187800963081862%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003equadratic\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e2.55\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e2.334\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e\u003cstrong\u003e0.021\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"19.74317817014446%\" valign=\"bottom\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd width=\"21.187800963081862%\"\u003e\n \u003cp\u003eEndo only\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003elinear\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e0.79\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e0.886\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e0.377\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"19.74317817014446%\" valign=\"bottom\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd width=\"21.187800963081862%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003equadratic\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e1.56\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e1.71\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e0.089\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"19.74317817014446%\" valign=\"bottom\"\u003e\n \u003cp\u003e\u003cstrong\u003eDASS-A\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"21.187800963081862%\" valign=\"top\"\u003e\n \u003cp\u003eEndo+IBS\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003elinear\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e0.94\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e1.09\u003c/p\u003e\n \u003c/td\u003e\n 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width=\"14.76725521669342%\"\u003e\n \u003cp\u003e0.201\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"19.74317817014446%\" valign=\"bottom\"\u003e\n \u003cp\u003e\u003cstrong\u003eDASS-S\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"21.187800963081862%\" valign=\"top\"\u003e\n \u003cp\u003eEndo+IBS\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003elinear\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e-0.21\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e-0.196\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e0.845\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"19.74317817014446%\" valign=\"bottom\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd width=\"21.187800963081862%\"\u003e\n 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width=\"21.187800963081862%\" valign=\"top\"\u003e\n \u003cp\u003eEndo+IBS\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003elinear\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e2.39\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e0.933\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e0.352\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"19.74317817014446%\" valign=\"bottom\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd width=\"21.187800963081862%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003equadratic\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e8.81\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n 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valign=\"bottom\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd width=\"21.187800963081862%\"\u003e\n \u003cp\u003eEndo only\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003elinear\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e-0.41\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e-2.88\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e\u003cstrong\u003e0.004\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"19.74317817014446%\" valign=\"bottom\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd width=\"21.187800963081862%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003equadratic\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n 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\u003cp\u003elinear\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e-2.59\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e-1.815\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e0.071\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"19.74317817014446%\" valign=\"bottom\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd width=\"21.187800963081862%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003equadratic\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e6.18\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e4.029\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026lt;\u0026thinsp;.001\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"19.74317817014446%\" valign=\"bottom\"\u003e\n \u003cp\u003e\u003cstrong\u003ePCS-H\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"21.187800963081862%\" valign=\"top\"\u003e\n \u003cp\u003eEndo+IBS\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003elinear\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e-1.84\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e-3.0263\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e\u003cstrong\u003e0.003\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"19.74317817014446%\" valign=\"bottom\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd width=\"21.187800963081862%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003equadratic\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e1.13\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e1.8473\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e0.066\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"19.74317817014446%\" valign=\"bottom\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd width=\"21.187800963081862%\"\u003e\n \u003cp\u003eEndo only\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003elinear\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e-2.43\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e-4.8501\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026lt;\u0026thinsp;.001\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"19.74317817014446%\" valign=\"bottom\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd width=\"21.187800963081862%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003equadratic\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e-0.03\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e-0.0544\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e0.957\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"19.74317817014446%\" valign=\"bottom\"\u003e\n \u003cp\u003e\u003cstrong\u003ePCS-M\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"21.187800963081862%\" valign=\"top\"\u003e\n \u003cp\u003eEndo+IBS\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003elinear\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e-0.21\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e-0.562\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e0.574\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"19.74317817014446%\" valign=\"bottom\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd width=\"21.187800963081862%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003equadratic\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e0.99\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e2.619\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e\u003cstrong\u003e0.009\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"19.74317817014446%\" valign=\"bottom\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd width=\"21.187800963081862%\"\u003e\n \u003cp\u003eEndo only\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003elinear\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e-0.61\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e-1.962\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e0.051\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"19.74317817014446%\" valign=\"bottom\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd width=\"21.187800963081862%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003equadratic\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e0.23\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e0.722\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e0.471\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"19.74317817014446%\" valign=\"bottom\"\u003e\n \u003cp\u003e\u003cstrong\u003ePCS-R\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"21.187800963081862%\" valign=\"top\"\u003e\n \u003cp\u003eEndo+IBS\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003elinear\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e-1.83\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e-3.8718\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026lt;\u0026thinsp;.001\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"19.74317817014446%\" valign=\"bottom\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd width=\"21.187800963081862%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003equadratic\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e1.99\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e4.1858\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026lt;\u0026thinsp;.001\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"19.74317817014446%\" valign=\"bottom\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd width=\"21.187800963081862%\"\u003e\n \u003cp\u003eEndo only\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003elinear\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e-2.44\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e-6.2484\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026lt;\u0026thinsp;.001\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"19.74317817014446%\" valign=\"bottom\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd width=\"21.187800963081862%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003equadratic\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e0.02\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e0.0615\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e0.951\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"19.74317817014446%\" valign=\"bottom\"\u003e\n \u003cp\u003e\u003cstrong\u003ePCS-T\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"21.187800963081862%\" valign=\"top\"\u003e\n \u003cp\u003eEndo+IBS\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003elinear\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e-3.84\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e-3.119\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e\u003cstrong\u003e0.002\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"19.74317817014446%\" valign=\"bottom\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd width=\"21.187800963081862%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003equadratic\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e4.14\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e3.367\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026lt;\u0026thinsp;.001\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"19.74317817014446%\" valign=\"bottom\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd width=\"21.187800963081862%\"\u003e\n \u003cp\u003eEndo only\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003elinear\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e-5.49\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e-5.416\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026lt;\u0026thinsp;.001\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"19.74317817014446%\" valign=\"bottom\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"21.187800963081862%\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003equadratic\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e0.28\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e0.266\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"14.76725521669342%\"\u003e\n \u003cp\u003e0.79\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e\u0026nbsp;\u003cem\u003eB\u003c/em\u003e = fixed effects co-efficient, \u003cem\u003et\u0026nbsp;\u003c/em\u003e= t-test, \u003cem\u003ep\u003c/em\u003e\u0026thinsp;=\u0026thinsp;test of significance, two-tailed with a threshold of\u0026thinsp;\u0026lt;\u0026thinsp;0.05, 95% confidence interval. Measure abbreviations: DASS-A: Depression Anxiety and Stress Scale\u0026ndash;anxiety subscale; DASS-D: Depression Anxiety and Stress Scale\u0026ndash;depression subscale; DASS-S: Depression Anxiety and Stress Scale\u0026ndash;stress subscale; DASS-T: Depression Anxiety and Stress Scale\u0026ndash;Total; NRS: Pain Numerical Response Scale; FSI: Fatigue Symptom Inventory; \u0026nbsp;PCS-H: Pain Catastrophizing Scale\u0026ndash;helplessness subscale; PCS-M: Pain Catastrophizing Scale\u0026ndash;magnification subscale; PCS-R: Pain Catastrophizing Scale-rumination subscale; PCS-T: Pain Catastrophizing Scale-Total\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eTrend findings for pain severity also demonstrated rebound patterns for both groups from T2 to T3. However, a slightly faster reduction in pain severity levels was observed in the Endo+IBS group compared to the EndoOnly group (\u003cstrong\u003eFigure 2\u003c/strong\u003e). This resembled the trends observed for rumination and total pain catastrophising, whereby the EndoOnly group experienced sustained linear improvements in helplessness, whilst the Endo+IBS group showed a trend for a slight increase in helplessness at T3 (\u003cstrong\u003eFigure 3\u003c/strong\u003e).\u003c/p\u003e\n\u003cp\u003eExamination of the simple effects revealed significant positive quadratic effects for fatigue in both groups. Significant positive quadratic effects for psychological distress (depression, anxiety, stress, and distress overall) and magnification were also found for the Endo+IBS group. The observed positive quadratic effects indicated initial reductions from baseline that attenuated or reversed by T3.\u0026nbsp;Examination of all significant models revealed that aside from pain severity,\u0026nbsp;the Endo+IBS group reported poorer outcomes on each measure compared with the EndoOnly group at T1 and T3. Notably, across both groups, a trend for improvement in most outcome measures (except for psychological QoL and menstrual symptoms for EndoOnly and social relationships QoL for Endo+IBS) was observed at T2.\u0026nbsp;The complete set of omnibus fixed effects, parameter estimates, and simple effects are available in the Supplementary Information (SI1-SI4).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003ePost-Hoc Comparisons\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003ePost hoc comparisons within and between groups were performed for each outcome. \u003cstrong\u003eTable 6\u003c/strong\u003e presents the significant post hoc comparisons for T1 and T3 only. Both the EndoOnly and Endo+IBS groups showed significantly reduced scores on measures of pain severity, helplessness, rumination, and total pain catastrophising from baseline to 24-month follow-up. Elsewhere, we observed significant improvements in fatigue for both groups from T1 to T2 (EndoOnly: \u003cem\u003eMD\u003c/em\u003e =9.40 , \u003cem\u003et\u003c/em\u003e = 4.99 , \u003cem\u003ep \u0026lt;.\u003c/em\u003e001; Endo+IBS: \u003cem\u003eMD\u003c/em\u003e =7.24, \u003cem\u003et\u0026nbsp;\u003c/em\u003e=3.32, \u003cem\u003ep\u003c/em\u003e =.001), however significant increases were reported from T2 to T3 (EndoOnly: \u003cem\u003eMD\u003c/em\u003e =-5.74, \u003cem\u003et\u003c/em\u003e =-2.43, \u003cem\u003ep\u0026nbsp;\u003c/em\u003e=.016; Endo+IBS: \u003cem\u003eMD\u003c/em\u003e =-9.15, \u003cem\u003et\u003c/em\u003e =-3.20, \u003cem\u003ep\u003c/em\u003e=.002).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTable 6 \u0026ndash;\u0026nbsp;\u003c/strong\u003eSignificant Post Hoc Comparisons Within and Between EndoOnly and Endo+IBS for T1 and T3\u003c/p\u003e\n\u003ctable border=\"1\" cellspacing=\"0\" cellpadding=\"0\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd width=\"12.479201331114808%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.312811980033278%\" valign=\"bottom\"\u003e\n \u003cp\u003e\u003cstrong\u003eGroup\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.153078202995008%\" valign=\"bottom\"\u003e\n \u003cp\u003e\u003cstrong\u003eTime\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.146422628951747%\" valign=\"bottom\"\u003e\n \u003cp\u003e\u003cstrong\u003eGroup\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.820299500831947%\" valign=\"bottom\"\u003e\n \u003cp\u003e\u003cstrong\u003eTime\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.146422628951747%\" valign=\"bottom\"\u003e\n \u003cp\u003e\u003cstrong\u003eDifference\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.317803660565724%\" valign=\"bottom\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003eSE\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.81863560732113%\" valign=\"bottom\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003et\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.81863560732113%\" valign=\"bottom\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003edf\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.9866888519134775%\" valign=\"bottom\"\u003e\n \u003cp\u003e\u003cstrong\u003e\u003cem\u003ep\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"12.479201331114808%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eWQoL-Ph\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.312811980033278%\" valign=\"top\"\u003e\n \u003cp\u003eEndo+IBS\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.153078202995008%\" valign=\"top\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.146422628951747%\" valign=\"top\"\u003e\n \u003cp\u003eEndoOnly\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.820299500831947%\" valign=\"top\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.146422628951747%\" valign=\"top\"\u003e\n \u003cp\u003e-5.69\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.317803660565724%\" valign=\"top\"\u003e\n \u003cp\u003e1.96\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.81863560732113%\" valign=\"top\"\u003e\n \u003cp\u003e-2.90\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.81863560732113%\" valign=\"top\"\u003e\n \u003cp\u003e395\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.9866888519134775%\" valign=\"top\"\u003e\n \u003cp\u003e0.004\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"12.479201331114808%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eWQoL-Ps\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.312811980033278%\" valign=\"top\"\u003e\n \u003cp\u003eEndo+IBS\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.153078202995008%\" valign=\"top\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.146422628951747%\" valign=\"top\"\u003e\n \u003cp\u003eEndoOnly\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.820299500831947%\" valign=\"top\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.146422628951747%\" valign=\"top\"\u003e\n \u003cp\u003e-5.22\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.317803660565724%\" valign=\"top\"\u003e\n \u003cp\u003e1.87\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.81863560732113%\" valign=\"top\"\u003e\n \u003cp\u003e-2.79\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.81863560732113%\" valign=\"top\"\u003e\n \u003cp\u003e388\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.9866888519134775%\" valign=\"top\"\u003e\n \u003cp\u003e0.006\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"12.479201331114808%\" valign=\"top\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd width=\"12.312811980033278%\" valign=\"top\"\u003e\n \u003cp\u003eEndo+IBS\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.153078202995008%\" valign=\"top\"\u003e\n \u003cp\u003e3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.146422628951747%\" valign=\"top\"\u003e\n \u003cp\u003eEndoOnly\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.820299500831947%\" valign=\"top\"\u003e\n \u003cp\u003e3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.146422628951747%\" valign=\"top\"\u003e\n \u003cp\u003e-7.09\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.317803660565724%\" valign=\"top\"\u003e\n \u003cp\u003e3.32\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.81863560732113%\" valign=\"top\"\u003e\n \u003cp\u003e-2.13\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.81863560732113%\" valign=\"top\"\u003e\n \u003cp\u003e372\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.9866888519134775%\" valign=\"top\"\u003e\n \u003cp\u003e0.034\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"12.479201331114808%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eWQoL-S\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.312811980033278%\" valign=\"top\"\u003e\n \u003cp\u003eEndo+IBS\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.153078202995008%\" valign=\"top\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.146422628951747%\" valign=\"top\"\u003e\n \u003cp\u003eEndoOnly\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.820299500831947%\" valign=\"top\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.146422628951747%\" valign=\"top\"\u003e\n \u003cp\u003e-5.90\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.317803660565724%\" valign=\"top\"\u003e\n \u003cp\u003e2.51\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.81863560732113%\" valign=\"top\"\u003e\n \u003cp\u003e-2.35\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.81863560732113%\" valign=\"top\"\u003e\n \u003cp\u003e402\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.9866888519134775%\" valign=\"top\"\u003e\n \u003cp\u003e0.019\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"12.479201331114808%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eWQoL-E\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.312811980033278%\" valign=\"top\"\u003e\n \u003cp\u003eEndo+IBS\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.153078202995008%\" valign=\"top\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.146422628951747%\" valign=\"top\"\u003e\n \u003cp\u003eEndoOnly\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.820299500831947%\" valign=\"top\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.146422628951747%\" valign=\"top\"\u003e\n \u003cp\u003e-3.73\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.317803660565724%\" valign=\"top\"\u003e\n \u003cp\u003e1.86\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.81863560732113%\" valign=\"top\"\u003e\n \u003cp\u003e-2.01\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.81863560732113%\" valign=\"top\"\u003e\n \u003cp\u003e364\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.9866888519134775%\" valign=\"top\"\u003e\n \u003cp\u003e0.046\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"12.479201331114808%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eDASS - A\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.312811980033278%\" valign=\"top\"\u003e\n \u003cp\u003eEndo+IBS\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.153078202995008%\" valign=\"top\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.146422628951747%\" valign=\"top\"\u003e\n \u003cp\u003eEndoOnly\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.820299500831947%\" valign=\"top\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.146422628951747%\" valign=\"top\"\u003e\n \u003cp\u003e2.06\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.317803660565724%\" valign=\"top\"\u003e\n \u003cp\u003e0.92\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.81863560732113%\" valign=\"top\"\u003e\n \u003cp\u003e2.23\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.81863560732113%\" valign=\"top\"\u003e\n \u003cp\u003e387\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.9866888519134775%\" valign=\"top\"\u003e\n \u003cp\u003e0.026\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"12.479201331114808%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003ePain NSR\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.312811980033278%\" valign=\"top\"\u003e\n \u003cp\u003eEndoOnly\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.153078202995008%\" valign=\"top\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.146422628951747%\" valign=\"top\"\u003e\n \u003cp\u003eEndoOnly\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.820299500831947%\" valign=\"top\"\u003e\n \u003cp\u003e3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.146422628951747%\" valign=\"top\"\u003e\n \u003cp\u003e0.58\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.317803660565724%\" valign=\"top\"\u003e\n \u003cp\u003e0.20\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.81863560732113%\" valign=\"top\"\u003e\n \u003cp\u003e2.87\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.81863560732113%\" valign=\"top\"\u003e\n \u003cp\u003e249\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.9866888519134775%\" valign=\"top\"\u003e\n \u003cp\u003e0.004\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"12.479201331114808%\" valign=\"top\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd width=\"12.312811980033278%\" valign=\"top\"\u003e\n \u003cp\u003eEndo+IBS\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.153078202995008%\" valign=\"top\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.146422628951747%\" valign=\"top\"\u003e\n \u003cp\u003eEndo+IBS\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.820299500831947%\" valign=\"top\"\u003e\n \u003cp\u003e3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.146422628951747%\" valign=\"top\"\u003e\n \u003cp\u003e0.70\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.317803660565724%\" valign=\"top\"\u003e\n \u003cp\u003e0.25\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.81863560732113%\" valign=\"top\"\u003e\n \u003cp\u003e2.82\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.81863560732113%\" valign=\"top\"\u003e\n \u003cp\u003e250\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.9866888519134775%\" valign=\"top\"\u003e\n \u003cp\u003e0.005\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"12.479201331114808%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003ePCS - H\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.312811980033278%\" valign=\"top\"\u003e\n \u003cp\u003eEndoOnly\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.153078202995008%\" valign=\"top\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.146422628951747%\" valign=\"top\"\u003e\n \u003cp\u003eEndoOnly\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.820299500831947%\" valign=\"top\"\u003e\n \u003cp\u003e3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.146422628951747%\" valign=\"top\"\u003e\n \u003cp\u003e3.44\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.317803660565724%\" valign=\"top\"\u003e\n \u003cp\u003e0.71\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.81863560732113%\" valign=\"top\"\u003e\n \u003cp\u003e4.84\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.81863560732113%\" valign=\"top\"\u003e\n \u003cp\u003e221\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.9866888519134775%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026lt;\u0026thinsp;.001\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"12.479201331114808%\" valign=\"top\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd width=\"12.312811980033278%\" valign=\"top\"\u003e\n \u003cp\u003eEndo+IBS\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.153078202995008%\" valign=\"top\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.146422628951747%\" valign=\"top\"\u003e\n 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width=\"8.81863560732113%\" valign=\"top\"\u003e\n \u003cp\u003e229\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.9866888519134775%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026lt;\u0026thinsp;.001\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"12.479201331114808%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003ePCS-T\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.312811980033278%\" valign=\"top\"\u003e\n \u003cp\u003eEndoOnly\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.153078202995008%\" valign=\"top\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.146422628951747%\" valign=\"top\"\u003e\n \u003cp\u003eEndoOnly\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.820299500831947%\" valign=\"top\"\u003e\n \u003cp\u003e3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.146422628951747%\" valign=\"top\"\u003e\n \u003cp\u003e7.77\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.317803660565724%\" valign=\"top\"\u003e\n \u003cp\u003e1.44\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.81863560732113%\" valign=\"top\"\u003e\n \u003cp\u003e5.40\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.81863560732113%\" valign=\"top\"\u003e\n \u003cp\u003e218\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.9866888519134775%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026lt;\u0026thinsp;.001\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"12.479201331114808%\" valign=\"top\"\u003e\u003cbr\u003e\u003c/td\u003e\n \u003ctd width=\"12.312811980033278%\" valign=\"top\"\u003e\n \u003cp\u003eEndo+IBS\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.153078202995008%\" valign=\"top\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.146422628951747%\" valign=\"top\"\u003e\n \u003cp\u003eEndo+IBS\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.820299500831947%\" valign=\"top\"\u003e\n \u003cp\u003e3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.146422628951747%\" valign=\"top\"\u003e\n \u003cp\u003e5.43\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.317803660565724%\" valign=\"top\"\u003e\n \u003cp\u003e1.74\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.81863560732113%\" valign=\"top\"\u003e\n \u003cp\u003e3.11\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.81863560732113%\" valign=\"top\"\u003e\n \u003cp\u003e218\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.9866888519134775%\" valign=\"top\"\u003e\n \u003cp\u003e0.002\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"12.479201331114808%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eFSI\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.312811980033278%\" valign=\"top\"\u003e\n \u003cp\u003eEndo+IBS\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.153078202995008%\" valign=\"top\"\u003e\n \u003cp\u003e3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.146422628951747%\" valign=\"top\"\u003e\n \u003cp\u003eEndoOnly\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.820299500831947%\" valign=\"top\"\u003e\n \u003cp\u003e3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.146422628951747%\" valign=\"top\"\u003e\n \u003cp\u003e8.15\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.317803660565724%\" valign=\"top\"\u003e\n \u003cp\u003e3.21\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.81863560732113%\" valign=\"top\"\u003e\n \u003cp\u003e2.54\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.81863560732113%\" valign=\"top\"\u003e\n \u003cp\u003e345\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.9866888519134775%\" valign=\"top\"\u003e\n \u003cp\u003e0.012\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"12.479201331114808%\" valign=\"top\"\u003e\n \u003cp\u003e\u003cstrong\u003eMSS\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.312811980033278%\" valign=\"top\"\u003e\n \u003cp\u003eEndo+IBS\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.153078202995008%\" valign=\"top\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.146422628951747%\" valign=\"top\"\u003e\n \u003cp\u003eEndoOnly\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.820299500831947%\" valign=\"top\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"12.146422628951747%\" valign=\"top\"\u003e\n \u003cp\u003e4.78\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.317803660565724%\" valign=\"top\"\u003e\n \u003cp\u003e1.64\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.81863560732113%\" valign=\"top\"\u003e\n \u003cp\u003e2.91\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.81863560732113%\" valign=\"top\"\u003e\n \u003cp\u003e399\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.9866888519134775%\" valign=\"top\"\u003e\n \u003cp\u003e0.004\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\n\u003cp\u003e\u003cem\u003eSE\u003c/em\u003e = standard error, \u003cem\u003et\u0026nbsp;\u003c/em\u003e= t-test, \u003cem\u003edf\u0026nbsp;\u003c/em\u003e= degrees of freedom, \u003cem\u003ep\u003c/em\u003e\u0026thinsp;=\u0026thinsp;test of significance, two-tailed with a threshold of\u0026thinsp;\u0026lt;\u0026thinsp;0.05, 95% confidence interval. Measure abbreviations: WQoL-Ph: World Health Organisation Quality of Life Assessment (WHOQOL-BREF)-physical health subscale; WQoL-Ps: WHOQOL-BREF-psychological health subscale; WQoL-SR: WHOQOL-BREF-social relationships subscale: WQoL-E: WHOQOL-BREF-environment subscale: DASS-A: Depression Anxiety and Stress Scale\u0026ndash;anxiety subscale; DASS-D: Depression Anxiety and Stress Scale\u0026ndash;depression subscale; DASS-S: Depression Anxiety and Stress Scale\u0026ndash;stress subscale; DASS-T: Depression Anxiety and Stress Scale\u0026ndash;Total; NRS: Pain Numerical Response Scale; BPI: Brief Pain Inventory PCS-H: Pain Catastrophizing Scale\u0026ndash;helplessness subscale; PCS-M: Pain Catastrophizing Scale\u0026ndash;magnification subscale; PCS-R: Pain Catastrophizing Scale-rumination subscale; FSI: Fatigue Symptom Inventory; MSS: Menstrual Symptom Scale\u003c/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003c/p\u003e\n\u003cp\u003eResults also showed significant differences between the groups at T3, with the Endo+IBS group reporting significantly lower psychological QoL and significantly higher fatigue than the EndoOnly group.\u0026nbsp;Interestingly, the Endo+IBS group demonstrated a tendency towards rebound patterns from T2 to T3, with post hoc comparisons revealing significant increases in symptoms of depression (\u003cem\u003eMD\u003c/em\u003e =-4.25 , \u003cem\u003et\u003c/em\u003e =-2.47 , \u003cem\u003ep=.\u003c/em\u003e014), anxiety (\u003cem\u003eMD\u003c/em\u003e =-4.59 , \u003cem\u003et\u003c/em\u003e =-3.24 , \u003cem\u003ep=.\u003c/em\u003e001), stress (\u003cem\u003eMD\u003c/em\u003e =-3.60 , \u003cem\u003et\u003c/em\u003e =-2.03 , \u003cem\u003ep=.\u003c/em\u003e043), distress overall (\u003cem\u003eMD\u003c/em\u003e =-12.48 , \u003cem\u003et\u003c/em\u003e =-2.98 , \u003cem\u003ep=.\u003c/em\u003e003) and fatigue (\u003cem\u003eMD\u003c/em\u003e =-9.15 , \u003cem\u003et\u003c/em\u003e =-3.20 , \u003cem\u003ep=.\u003c/em\u003e002) from 12-months to 24-months follow up. Conversely, we observed increases in social QoL (\u003cem\u003eMD\u003c/em\u003e =-8.72 , \u003cem\u003et\u003c/em\u003e =-2.07, \u003cem\u003ep=.\u003c/em\u003e04) for the Endo+IBS group over the same period. The complete set of significant post hoc comparisons at all time points is available in the Supplementary Information (SI5).\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003eThis prospective longitudinal study is the first to explore and compare the changes in biopsychosocial outcomes between individuals living with endometriosis (EndoOnly) and those living with co-occurring IBS-type symptoms (Endo+IBS) over time. Our findings suggested that individuals with Endo+IBS were more likely to experience lower HRQoL and higher functional pain disability, fatigue, and menstrual symptoms compared to individuals with EndoOnly over three years. Results also indicated that individuals with EndoOnly experienced lower and more consistent decreases in levels of pain catastrophising, especially rumination; whilst for individuals with Endo+IBS, initial declines in scores appeared to diminish or regress over time. Our exploratory observations also implied that individuals with Endo+IBS tended to exhibit more complex change trajectories in pain severity, psychological distress, helplessness, magnification, and fatigue over time, with a trend towards poorer outcomes overall. Notably, the occurrence of the COVID-19 global pandemic during the study seemingly influenced the outcome trajectories amongst both groups, with inconsistent patterns of change observed across several outcome measures. Collectively, these findings provide valuable insights into the unique challenges faced by individuals living with comorbidities and the enduring impacts on health-related factors and overall QoL.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eThe complex relationships between endometriosis and co-occurring conditions have been previously described\u0026nbsp;[4,6,34], with evidence showing an increased risk of gastrointestinal disorders in endometriosis populations\u0026nbsp;[15,30,57-59]. In this study, a high prevalence of IBS-type symptoms in individuals with endometriosis (42.3%) was observed, consistent with a recent meta-analysis which found prevalence rates of IBS ranging from 10.6% to 52% (pooled prevalence of 23.4%;\u0026nbsp;[60]). Two factors may explain the notably high occurrence of IBS-type symptoms in our study. Firstly, the sample from the original study included individuals with self-reported dysmenorrhea, which is associated with an increased risk of co-occurring IBS\u0026nbsp;[61-63], although prevalence ranges are comparative to other populations\u0026nbsp;[61,64,65]. Secondly, in this study, a combination of self-reported diagnosis and the Rome IV-IBS criteria was used to classify participants, which most likely extended the scope of included IBS-type symptom cases\u0026nbsp;[66].\u003c/p\u003e\n\u003cp\u003eBoth individuals with endometriosis and individuals with IBS experience a greater burden of comorbidities compared with healthy populations\u0026nbsp;[5,6,31,57,67]. For individuals with endometriosis, comorbidities are associated with impaired physical, psychological, and social functioning, causing detrimental disruptions to everyday life\u0026nbsp;[7,35,68-70]. Our observations of significant differences at baseline and generally worse longitudinal outcomes for the Endo+IBS group are compatible with these findings and support the burden of comorbidity on individual health outcomes overall. Furthermore, a recent retrospective biobank cohort study (\u003cem\u003eN\u003c/em\u003e = 65, 421) revealed that individuals living with both endometriosis and IBS are more likely to suffer from multiple co-occurring conditions and experience greater abdominal and pelvic pain compared to individuals with endometriosis or IBS alone\u0026nbsp;[57]. In endometriosis and IBS, disease-related pain is significantly associated with increased symptoms of depression and anxiety, pain catastrophising and fatigue\u0026nbsp;[35,37,40,71-73], whilst disease severity may directly influence how individuals with IBS adaptively cope with and respond to pain\u0026nbsp;[74-76]. Accordingly, the presence of comorbid IBS-type symptoms in endometriosis potentially influences individual responses to condition-related factors and may exacerbate adverse health outcomes, impairing overall HRQoL. Our findings emphasise the inherent, persistent, and compounding effect of comorbid chronic conditions on individual health and wellbeing and highlight the complexities and challenges for health management, treatment, and ongoing care\u0026nbsp;[77].\u003c/p\u003e\n\u003cp\u003ePain catastrophising is a negative cognitive-emotional response to actual or anticipated pain and a critical predictor of pain-related outcomes. It is significantly associated with compromised functioning, increased symptoms of depression and anxiety, greater pain severity and sensitivity and reduced HRQoL across endometriosis and IBS populations\u0026nbsp;[36,37,78-80]. This study confirmed significant decreases in rumination and pain catastrophising for both groups over time, however with notably distinctive trajectories. These results are somewhat surprising, given our other observations for pain severity and disability, psychological distress, fatigue and HRQoL, which concurrently revealed unstable trends, rebound effects and potential worsening over time. Regarding pain catastrophising specifically, we found continuous, linear decreases for the EndoOnly group, suggesting potential increased resilience within this sample\u0026nbsp;[81,82], or potentially greater use of adaptive coping strategies in response to pain\u0026nbsp;[83]. Conversely, trends for individuals with Endo+IBS were not stable, and after an initial decline in levels of pain catastrophising, results rebounded or diminished over time. These findings suggest that the added burden of comorbid IBS-type symptoms may heighten catastrophic thinking about pain, or potentially increase individual sensitivity to cyclical changes or external and environmental stressors\u0026nbsp;[71,84,85]. Given that health outcomes are directly affected by how individuals cope with and respond to pain, the development of personalised targeted interventions to address and support cognitive and emotional processes associated with pain catastrophising may help to optimise treatment success and improve overall QoL, for both individuals living with EndoOnly and individuals with Endo+IBS\u0026nbsp;[79,85].\u003c/p\u003e\n\u003cp\u003eThe\u0026nbsp;COVID-19 global pandemic presented unprecedented health challenges and concerns, especially for individuals living with chronic conditions. In addition to the fear of contracting the SARS-CoV-2 virus, public health measures such as social distancing, mandatory lockdowns, and limitations on services, substantially impacted psychosocial wellbeing\u0026nbsp;[86]. Individuals living with endometriosis have reported significant declines in physical, psychological and/or social health as a result of the COVID-19 pandemic\u0026nbsp;[87,88],\u0026nbsp;with similar negative outcomes reported by individuals with gastrointestinal disorders, such as IBS\u0026nbsp;[89-92]. A\u0026nbsp;recent meta-analysis exploring the impacts of COVID-19 on endometriosis (\u003cem\u003eN\u003c/em\u003e = 15) found that individuals with endometriosis experienced increased symptoms of pain, depression, anxiety, and fatigue during the\u0026nbsp;pandemic\u0026nbsp;[93], negatively compromising overall HRQoL. Paradoxically, this study observed trends towards improvements in outcome measures for both groups at 12-month follow-up (T2), particularly for the Endo+IBS group, which coincided with the peak of mandatory COVID-19 restrictions in Australia. Our findings are consistent with studies in endometriosis and IBS populations, which have demonstrated improved disease severity, enhanced symptom management, increased productivity, and lower condition-related stress resulting from COVID-19-related flexible working arrangements, reduced daily work commutes and limited exposure to extrinsic stressors\u0026nbsp;[94-97].\u003c/p\u003e\n\u003cp\u003eInterestingly, we also observed rebound trends from T2 to T3 for most outcomes (supported, in part, by significant post hoc comparisons), most prominently for the Endo+IBS group. Our findings are consistent with global studies which have found that physical and mental health trajectories were significantly disrupted and showed complex patterns of change as a direct result of COVID-19 public health measures\u0026nbsp;[98-101]. Notably, a recent survey of Australian adults (\u003cem\u003eN\u003c/em\u003e = 574,306) found that psychological distress initially increased during lockdown, however quickly stabilised, then rapidly declined after restrictions were lifted, but not to pre-COVID-19 levels\u0026nbsp;[102]. Furthermore, although we did not collect data on confirmed SARS-CoV-2 infections, emerging evidence suggests that exposure to the SARS-CoV-2 virus potentially causes long-term changes in gut-brain messaging that may lead to IBS or other disordered gut-brain interactions\u0026nbsp;[90,103]. Studies have shown that individuals who have previously contracted the\u0026nbsp;SARS-Cov-2\u0026nbsp;virus have reported increased rates of post-infection IBS and more severe gastrointestinal issues\u0026nbsp;[104,105]. Moreover, exposure to the\u0026nbsp;SARS-Cov-2\u0026nbsp;virus appears to worsen pre-existing symptoms for individuals already living with IBS\u0026nbsp;[106]. Our findings suggest that COVID-19 public health restrictions had a marked and considerable influence on the health outcome trajectories for both groups, particularly for the Endo+IBS group, and most likely explains the inconsistent and unpredictable trajectories observed. Furthermore, the emerging evidence supporting the link between the SARS-CoV-2 virus and gastrointestinal manifestations should not be ignored and may provide deeper insights into the unusual patterns of change and the burden of living with IBS comorbidity. Future studies should examine whether these effects are uniquely transitory, or if there are ongoing, residual influences of COVID-19 restrictions and/or the SARS-CoV-2 virus that may influence health outcomes for these populations.\u003c/p\u003e\n\u003cp\u003eAlthough comorbidity is very common and has significant detrimental impacts on individuals and the healthcare system more broadly, research exploring the development of targeted interventions and tailored approaches to health management are limited\u0026nbsp;[107]. By understanding the trajectories and changes in health outcomes for individuals living with endometriosis and comorbid IBS, healthcare providers can improve condition management and treatment success, and help to identify person-centred, adaptive approaches that respond to individual requirements, symptoms, and priorities. Our research underscores the need for greater practitioner awareness of the relationship between endometriosis and IBS to mitigate misdiagnosis, mistreatment, and diagnostic delays. Furthermore, study findings provide evidence-based insights to inform healthcare practices and strategies that may alleviate the long-term health impact of comorbid IBS and help to promote greater wellbeing and HRQoL. Accordingly, a multidisciplinary approach to managing these complex and multifactorial conditions is strongly recommended and critically needed to enhance the patient experience and improve health outcomes overall. Finally, our observations contribute to the growing body of research examining the physical and psychosocial health consequences of COVID-19, potentially informing further studies and public health responses. Future research should focus on exploring the underlying mechanisms of comorbid relationships, including shared risk factors and genetic biological markers\u0026nbsp;[59,108,109], along with examining the complex interaction of health behaviours, psychological processes, and extrinsic factors, to help optimise the health and wellbeing of individuals living with endometriosis and endometriosis with co-occurring IBS.\u003c/p\u003e\n\u003cp\u003eStrengths of this study include the prospective design, with follow-up of the same cohort across three years, along with the sample size, which was sufficient to power the study. Notwithstanding, our findings should be interpreted in the context of study limitations. Firstly, the attrition rate was high and individual item data was missing. However, loss to follow up is common in longitudinal studies and the application of LMM analyses may help to mitigate any potential biases. The use of self-selected sampling and self-reported measures \u0026nbsp;to collect participant data, along with the use of Rome-IV to categorise participants with IBS-type symptoms also raises the potential for representation and information bias. It is also recognised that certain types of endometrioses (for example bowel endometriosis) may have over-estimated the presence of IBS in this study and future research should potentially identify and/or specify different types of endometriosis sub-groups. Further, the original sample of women with dysmenorrhea may not be representative of the broader population, limiting our generalisability. Finally, the lack of observed interaction effects may have been influenced by shared external factors, such as COVID-19 restrictions, which potentially produced the large number of quadratic effects and unusual trajectories observed in this study. Future research, including a follow up survey with this sample, is needed to examine the identified outcome variables in typical or unaffected environmental contexts and to properly elucidate any potential impacts and patterns of change.\u003c/p\u003e\n\u003cp\u003eIn conclusion, this longitudinal study provides valuable insight into the complex changes and differences of biopsychosocial outcomes between individuals with endometriosis and individuals with endometriosis and co-occurring IBS-type symptoms over time. It highlights the enduring and pervasive influence of comorbid IBS-type symptoms on health and wellbeing and emphasises the need for individualised and adaptable interventions and healthcare approaches that meet the unique challenges faced by individuals living with comorbidity. Future research should focus on the underlying mechanisms, processes and potential environmental stressors that influence the long-term health of individuals living with endometriosis and IBS-type symptoms, to optimise health outcomes, individual wellbeing and overall HRQoL.\u0026nbsp;\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eData Availability\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe de-identified, anonymised data underlying this article may be shared on reasonable request to the corresponding author.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAcknowledgements\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe authors wish to acknowledge and thank the participants who contributed their time to complete the study and the organisations involved in participant recruitment and advertising of the study.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAuthors Contributions\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eAll authors were involved in the conception and design of the study. Authors S.C. and DS performed the data analysis and interpretation of results. Author S.C prepared the draft manuscript and Supplementary Information. All authors reviewed and contributed to the revised paper and approved the final article for publication.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCompeting Interests\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNo specific funding was provided for this study. Author S.C is supported by a Commonwealth funded PhD scholarship. Author L.V.N is a member of the Endometriosis Australia Clinical Advisory Committee (non-financial) and the NECST Steering Committee (non-financial). Author A.M-W is a member of the NECST Steering Committee (non-financial). Authors S.E and A.M-W are recipients of several grants from the Medical Research Future Fund (MRFF), Victorian Government Department of Health and philanthropic organisations for the development and testing of psychological interventions to support people living with persistent pelvic pain, including endometriosis, outside of this research study. Author D.S has no financial or non-financial competing interests to declare.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eSupplementary Information\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eSupplementary Information are available at \u003cem\u003eScientific Reports\u003c/em\u003e online.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cbr\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\u003cli\u003e\u003cspan\u003eGiudice, L. C. Endometriosis. 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Nature Genetics 55, 423\u0026ndash;436, \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003ehttps://doi.org/10.1038/s41588-023-01323-z\u003c/span\u003e\u003cspan address=\"10.1038/s41588-023-01323-z\" targettype=\"DOI\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e (2023).\u003c/span\u003e\u003c/li\u003e\u003c/ol\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"endometriosis, irritable bowel syndrome, comorbid, pain, quality of life, COVID-19","lastPublishedDoi":"10.21203/rs.3.rs-4505378/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-4505378/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eEndometriosis and irritable bowel syndrome (IBS) share common pathophysiological and risk factors, often leading to misdiagnosis, diagnostic delays, and treatment implications. Further, both conditions are associated with biopsychosocial comorbidities, resulting in compromised wellbeing and reduced health-related quality of life (HRQoL). This longitudinal prospective study consisting of 610 adult women with endometriosis (EndoOnly; \u003cem\u003en\u003c/em\u003e\u0026thinsp;=\u0026thinsp;352), and with endometriosis and co-occurring IBS-type symptoms (Endo\u0026thinsp;+\u0026thinsp;IBS; \u003cem\u003en\u003c/em\u003e\u0026thinsp;=\u0026thinsp;258) aimed to investigate the differences in biopsychosocial factors, specifically HRQoL, psychological distress, pain, fatigue and menstrual symptoms over a three-year period. Using linear mixed models, results demonstrated that individuals with Endo\u0026thinsp;+\u0026thinsp;IBS were more likely to experience lower HRQoL and higher functional pain disability, fatigue, and menstrual symptoms compared to individuals with EndoOnly over three years. Results showed significant linear declines in rumination, total pain catastrophising, pain severity and helplessness for both groups; however, the rate of change for the Endo\u0026thinsp;+\u0026thinsp;IBS group tended to diminish and change direction over time. Further individuals with Endo\u0026thinsp;+\u0026thinsp;IBS were inclined to exhibit more complex change trajectories in psychological distress, magnification, and fatigue over time, with a trend towards worse outcomes overall. The onset of the COVID-19 during the study appeared to produce unexpected and inconsistent patterns of change for both groups. Findings highlight important implications for the implementation of multidisciplinary psychosocial healthcare, to help improve diagnosis, clinical management and overall health outcomes for individuals living with endometriosis and co-occurring IBS-type symptoms.\u003c/p\u003e","manuscriptTitle":"Exploring Biopsychosocial Health Outcomes in Endometriosis and Endometriosis with Co-occurring Irritable Bowel Syndrome – A Prospective Cohort Study","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2024-06-18 16:37:51","doi":"10.21203/rs.3.rs-4505378/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"90b158e3-8b16-440c-99d4-a1f85c97c8a6","owner":[],"postedDate":"June 18th, 2024","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":33093771,"name":"Biological sciences/Psychology"},{"id":33093772,"name":"Health sciences/Gastroenterology/Gastrointestinal diseases/Functional gastrointestinal disorders"},{"id":33093773,"name":"Health sciences/Health care/Quality of life"},{"id":33093774,"name":"Health sciences/Health care/Health policy"},{"id":33093775,"name":"Health sciences/Risk factors"},{"id":33093776,"name":"Health sciences/Signs and symptoms/Comorbidities"},{"id":33093777,"name":"Health sciences/Signs and symptoms/Digestive signs and symptoms"},{"id":33093778,"name":"Health sciences/Signs and symptoms/Pain"},{"id":33093779,"name":"Health sciences/Signs and symptoms/Reproductive signs and symptoms"},{"id":33093780,"name":"Health sciences/Diseases/Reproductive disorders"}],"tags":[],"updatedAt":"2024-11-26T16:39:14+00:00","versionOfRecord":[],"versionCreatedAt":"2024-06-18 16:37:51","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-4505378","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-4505378","identity":"rs-4505378","version":["v1"]},"buildId":"B-jG_2CBjPDmsCi4Wdhf-","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}