Migraine in relation with endometriosis phenotypes: Results from a French case-control study

Lorraine Maitrot‐Mantelet, Lorraine Maitrot-Mantelet, Justine Hugon-Rodin, Justine Hugon‐Rodin, Magali Vatel, Louis Marcellin, Piétro Santulli, Pietro Santulli, Charles Chapron, Geneviève Plu-Bureau, Geneviève Plu‐Bureau
Cephalalgia : an international journal of headache · 2019 · vol. 40(6) , pp. 606–613 · doi:10.1177/0333102419893965 · PMID:31810400 · W2992022451
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Migraine prevalence was higher in women with endometriosis, particularly those with ovarian endometrioma and deep infiltrating endometriosis, and was associated with greater pelvic pain intensity.

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Abstract

Background Studies have shown a significant association between migraine and endometriosis, but no study has explored the relationship between migraine and endometriosis phenotypes: Superficial peritoneal endometriosis, ovarian endometrioma, and deep infiltrating endometriosis. Methods We conducted a case-control study using data collected from 314 women aged 18 to 42 years who had undergone surgery for benign gynecological conditions between January 2013 and December 2015. All women completed a self-administered headache questionnaire according to the IHS classification. Cases (n = 182) are women with histologically proven endometriosis and controls are women (n = 132) without endometriosis. Occurrence of migraine was studied according to endometriosis phenotypes. Results Migraine prevalence in cases was significantly higher compared with controls (35.2% vs. 17.4%, p = 0.003). The risk of endometriosis was significantly higher in migrainous women (OR = 2.62; 95% CI = 1.43–4.79). When we take into account endometriosis phenotypes, the risk of ovarian endometrioma and deep infiltrating endometriosis were significant (OR = 2.78; 95% CI = 1.11–6.98 and OR = 2.51; 95% CI = 1.25–5.07, respectively). In women with endometriosis, the intensity of chronic non-cyclical pelvic pain was significantly greater for those with migraine (visual analogic scale (VAS) = 3.6 ± 2.9) compared with the women without headache (VAS = 2.3 ± 2.8, p = 0.0065). Conclusion Our study shows a significant association between migraine and endometriosis. In clinical practice, women of reproductive age who suffer from migraine should be screened for endometriosis criteria in order to optimise the medical and therapeutic care of this condition.

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Outcome instruments

VAS-pain

Condition tags

endometriosisdie_deep_infiltratingendometrioma

MeSH descriptors

Endometriosis Endometriosis Migraine Disorders Adolescent Adult Case-Control Studies Endometriosis Female France France Humans Migraine Disorders Phenotype Young Adult

Citation neighborhood

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Cited by (21)

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