Endothelial nitric oxide synthase gene Glu298Asp polymorphism is associated with advanced stage endometriosis

Hoon Kim, Hyung‐Kwan Kim, Seung‐Yup Ku, Seung Yup Ku, Sung Hoon Kim, Gyoung Hoon Lee, Young Min Choi, Y. M. Choi, Jong Mee Kim, Jin Man Kim, Taek Hoo Lee, T. H. Lee, Soo Young Moon, Shin Yong Moon
Human Reproduction · 2009 · vol. 24(10) , pp. 2656–2659 · doi:10.1093/humrep/dep212 · PMID:19531501 · W2105391054
article OA: bronze CC0 ⤵ 13 in-corpus citations
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The endothelial nitric oxide synthase gene Glu298Asp polymorphism was found to be associated with advanced stage endometriosis in a Korean population, with the T allele being more frequent in affected women.

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Abstract

BACKGROUND: Altered expression of endothelial nitric oxide synthase (eNOS) has been reported to be involved in the development of endometriosis. The genotypes of eNOS gene (NOS3) may be responsible for variation in its enzymatic activity as well as plasma concentration of nitric oxide. The Glu298Asp polymorphism of the NOS3 may modulate angiogenesis and influence individual susceptibility to endometriosis. This study was designed to evaluate the association between the Glu298Asp polymorphism of the NOS3 and advanced stage endometriosis. METHODS: This study consisted of 299 women with advanced stage endometriosis and 459 control women without endometriosis in a Korean population. Genotyping results of the Glu298Asp polymorphism of the NOS3 were analyzed between the endometriosis and control group. RESULTS: The genotypic frequencies were significantly different between women with and without endometriosis. The frequency of the non-GG genotype (GT + TT) was higher in the endometriosis group than in the control group (P = 0.001). CONCLUSION: These findings suggest that the T allele, encoding aspartic acid, of the Glu298Asp polymorphism of the NOS3 may be associated with advanced stage endometriosis in the Korean population.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Amino Acid Substitution Endometriosis Nitric Oxide Synthase Type III Polymorphism, Genetic Adult Endometriosis Female Gene Frequency Genotype Humans Korea Middle Aged Nitric Oxide Synthase Type III

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