Endometriosis and Headache

Lars Jacob Stovner, Karen Aegidius, Karen Ægidius, Mattias Linde
Current pain and headache reports · 2011 · vol. 15(5) , pp. 415–419 · doi:10.1007/s11916-011-0209-z · PMID:21556708 · W2034620448
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

Endometriosis and headache share clinical and epidemiological similarities, potentially due to hormonal influences, common genetic susceptibility, or amplified pain sensitivity, suggesting a need for physician awareness.

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Abstract

Headache and endometriosis show some similarities in their clinical and epidemiological features that are probably due to the influence of female sexual hormones on both disorders. Epidemiological studies indicate that they are comorbid disorders. However, the nature of the comorbidity is not known with certainty, but a likely explanation may be common susceptibility genes. Another possibility is that, because they both are related to pain, increased pain sensitivity induced by one of the disorders may lead to a higher likelihood of developing the other, possibly mediated by nitrogen oxide or prostaglandins. A common link to the widespread use of estroprogestins may seem less probable. For physicians dealing with women with either of these disorders, awareness of the comorbidity may be helpful in the treatment of the patient.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Endometriosis Headache Headache Animals Comorbidity Endometriosis Endometriosis Female Headache Headache Humans

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (42)

Cited by (8)

Source provenance

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