Prostaglandin F2 alpha and E2 release by peritoneum with and without endometriosis.
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Peritoneal endometriotic implants release significantly more PGF2 alpha and PGE2 than adjacent normal peritoneum.
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Abstract
Peritoneal endometriotic implants and adjacent normal peritoneum from five patients were analyzed for prostaglandin (PG) release. Each tissue biopsy was incubated using medium 199 in triplicate at 37 degrees C for six hours, and PGF2 alpha and PGE2 concentrations were measured in the incubation medium every two hours. This study demonstrates that peritoneum involved with endometriosis releases significantly more PGF2 alpha and PGE2 (P less than .05) than adjacent normal peritoneum, and suggests that peritoneal endometriotic implants may be a source of the elevated peritoneal fluid PG levels previously reported in patients with endometriosis.
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Cited by (19)
- Endometrial epithelial–mesenchymal transition (EMT) by menstruation-related inflammatory factors during hypoxia 2021
- PGE2 and Thrombin Induce Myofibroblast Transdifferentiation via Activin A and CTGF in Endometrial Stromal Cells 2021
- Features of pain syndrome in genital endometriosis and migraine 2021
- Dual suppression of estrogenic and inflammatory activities for targeting of endometriosis 2015
- Enhanced epithelial to mesenchymal transition (EMT) and upregulated MYC in ectopic lesions contribute independently to endometriosis 2015
- Aromatase and endometriosis: estrogens play a role 2014
- A Critical Review of Endometriosis Pathology 2013
- Endometriosis and Headache 2011
- Endometriosis, need for a multidisciplinary clinical setting: the internist’s point of view 2010
- Endometriosis: Pathogenesis, diagnosis, therapy and association with cancer (Review) 2008
- Inflammatory Status Influences Aromatase and Steroid Receptor Expression in Endometriosis 2007
- Nerve fibres in peritoneal endometriosis 2006
- High density of small nerve fibres in the functional layer of the endometrium in women with endometriosis 2005
- Increased frequency of migraine among women with endometriosis 2004
- Estrogen production in endometriosis and use of aromatase inhibitors to treat endometriosis. 1999
- Endometriosis and Infertility 1997
- Prostaglandin E<sub>2</sub>Stimulates Aromatase Expression in Endometriosis-Derived Stromal Cells<sup>1</sup> 1997
- Elevation of the phospholipase A2 activity in peritoneal fluid cells from women with endometriosis 1994
- 3 Endometriosis: The host response 1993
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