Elevation of the phospholipase A2 activity in peritoneal fluid cells from women with endometriosis

M Sano, Masatoshi Sano, Sano M, T Morishita, Tetsuya Morishita, Morishita T, M Nozaki, Nozaki M, Masahiro Nozaki, Yokoyama M, Motofumi Yokoyama, M Yokoyama, Y Watanabe, Yoshitsugu Watanabe, Watanabe Y, Nakano H, H Nakano, Hitoo Nakano
Fertility and sterility · 1994 · vol. 61(4) , pp. 657–662 · doi:10.1016/s0015-0282(16)56642-4 · PMID:8150107 · W2410778974
article OA: closed CC0 ⤵ 15 in-corpus citations
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This study investigated phospholipase A2 activity in peritoneal fluid cells from women with endometriosis, finding it to be elevated.

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Abstract

ObjectiveTo assess the prostaglandin (PG) production on peritoneal fluid (PF) cells, phospholipase A2 (PLA2) activity of those cells in women with endometriosis was measured and compared with that of women without endometriosis.DesignProspective clinical controlled study.PatientsWomen who underwent laparoscopy and were found either to have endometriosis (n = 15) or not (n = 9) were included in this study. Mononuclear cells obtained from the patients at laparoscopy were immediately separated by a Ficoll-Paque technique, lysed by nitrogen cavitation, and stored at -80 degrees C.InterventionsPhospholipase A2 activity was measured by Dole assay using 1-palmitoyl-2-[1-14C] palmitoyl phosphatidyl choline and assessed on a protein basis and a cell number basis.ResultsThere were at least four measurable kinds of PLA2 activity detected in the cells: two calcium-dependent pH optima 7.0 and 9.0 activities and two calcium-independent pH optima 7.5 and 8.5 activities. A calcium-dependent and pH optima 9.0 activity was the highest, and it was significantly higher in women with endometriosis when compared with those who did not have endometriosis.ConclusionThese results indicate that the increase in the PGs in PF with endometriosis may be produced by PF cells in which PLA2 activity is elevated.

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Condition tags

endometriosis

MeSH descriptors

Ascitic Fluid Endometriosis Phospholipases A Adult Ascitic Fluid Ascitic Fluid Calcium Calcium Endometriosis Female Humans Hydrogen-Ion Concentration Kinetics Macrophages, Peritoneal Macrophages, Peritoneal Phospholipases A Phospholipases A2 Prospective Studies

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