Elevation of the phospholipase A2 activity in peritoneal fluid cells from women with endometriosis

M Sano, Masatoshi Sano, Sano M, T Morishita, Tetsuya Morishita, Morishita T, M Nozaki, Nozaki M, Masahiro Nozaki, Yokoyama M, Motofumi Yokoyama, M Yokoyama, Y Watanabe, Yoshitsugu Watanabe, Watanabe Y, Nakano H, H Nakano, Hitoo Nakano
Fertility and sterility · 1994 · vol. 61(4) , pp. 657–662 · doi:10.1016/s0015-0282(16)56642-4 · PMID:8150107 · W2410778974
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This study investigated phospholipase A2 activity in peritoneal fluid cells from women with endometriosis, finding it to be elevated.

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Abstract

OBJECTIVE: To assess the prostaglandin (PG) production on peritoneal fluid (PF) cells, phospholipase A2 (PLA2) activity of those cells in women with endometriosis was measured and compared with that of women without endometriosis. DESIGN: Prospective clinical controlled study. PATIENTS: Women who underwent laparoscopy and were found either to have endometriosis (n = 15) or not (n = 9) were included in this study. Mononuclear cells obtained from the patients at laparoscopy were immediately separated by a Ficoll-Paque technique, lysed by nitrogen cavitation, and stored at -80 degrees C. INTERVENTIONS: Phospholipase A2 activity was measured by Dole assay using 1-palmitoyl-2-[1-14C] palmitoyl phosphatidyl choline and assessed on a protein basis and a cell number basis. RESULTS: There were at least four measurable kinds of PLA2 activity detected in the cells: two calcium-dependent pH optima 7.0 and 9.0 activities and two calcium-independent pH optima 7.5 and 8.5 activities. A calcium-dependent and pH optima 9.0 activity was the highest, and it was significantly higher in women with endometriosis when compared with those who did not have endometriosis. CONCLUSION: These results indicate that the increase in the PGs in PF with endometriosis may be produced by PF cells in which PLA2 activity is elevated.

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Condition tags

endometriosis

MeSH descriptors

Ascitic Fluid Endometriosis Phospholipases A Adult Adult Ascitic Fluid Ascitic Fluid Ascitic Fluid Calcium Calcium Calcium Endometriosis Endometriosis Female Female Humans Humans Hydrogen-Ion Concentration Hydrogen-Ion Concentration Kinetics

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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