The peritoneal environment in endometriosis
This paper discusses endometriosis's association with infertility and pelvic pain, detailing how the disease causes scarring and anatomical distortion, potentially interfering with ovulation and ovum pickup.
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This paper discusses the peritoneal environment in endometriosis, focusing on how peritoneal fluid and pelvic immune and biochemical factors relate to pelvic pain and infertility. It synthesizes evidence that women with endometriosis may have altered peritoneal fluid parameters across the menstrual cycle, including changes in volume, prostanoids (e.g., thromboxane B2, 6-keto-prostaglandin F1α), and cellular populations such as macrophages and lymphocytes, and it links these local factors to effects on sperm motility, sperm penetration, and embryo cleavage in vitro or in animal models. A major caveat is that the article appears to be a narrative overview relying on heterogeneous prior studies rather than presenting new, unified experimental methods or patient-specific controls. This paper is centrally about endometriosis — it specifically reviews how the peritoneal fluid microenvironment and its immune/prostanoid components may contribute to endometriosis-associated pelvic pain and infertility.
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Cited by (14)
- Menstrual characteristics, bleeding and other non-pelvic-pain symptoms in women presenting with severe endometriotic disease 2020
- Pathological Aspects of Endometriosis 2012
- Endometriosis 2009
- Iron storage is significantly increased in peritoneal macrophages of endometriosis patients and correlates with iron overload in peritoneal fluid 2008
- Increased activation of nuclear factor-kappa B (NF-κB) in isolated peritoneal macrophages of patients with endometriosis 2007
- Effects of peritoneal fluid from endometriosis patients on the release of vascular endothelial growth factor by neutrophils and monocytes 2006
- Pathogenesis of Endometriosis: The Role of Peritoneal Fluid 1999
- Immunohistochemical assessment of superoxide dismutase expression in the endometrium in endometriosis and adenomyosis 1999
- Endometriotic disease: the role of peritoneal fluid 1998
- Endometriosis-associated pelvic pain: evidence for an association between the stage of disease and a history of chronic pelvic pain 1997
- The peritoneal environment in endometriosis 1996
- Elevation of the phospholipase A2 activity in peritoneal fluid cells from women with endometriosis 1994
- 8 Prostaglandins, prostaglandin inhibitors and their roles in gynaecological disorders 1992
- The aetiology and pathogenesis of endometriosis 1992
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