The peritoneal environment in endometriosis

In: Modern Approaches to Endometriosis · 1991 · pp. 79–96 · doi:10.1007/978-94-011-3864-2_5 · W136346154
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This paper discusses endometriosis's association with infertility and pelvic pain, detailing how the disease causes scarring and anatomical distortion, potentially interfering with ovulation and ovum pickup.

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This paper discusses the peritoneal environment in endometriosis, focusing on how peritoneal fluid and pelvic immune and biochemical factors relate to pelvic pain and infertility. It synthesizes evidence that women with endometriosis may have altered peritoneal fluid parameters across the menstrual cycle, including changes in volume, prostanoids (e.g., thromboxane B2, 6-keto-prostaglandin F1α), and cellular populations such as macrophages and lymphocytes, and it links these local factors to effects on sperm motility, sperm penetration, and embryo cleavage in vitro or in animal models. A major caveat is that the article appears to be a narrative overview relying on heterogeneous prior studies rather than presenting new, unified experimental methods or patient-specific controls. This paper is centrally about endometriosis — it specifically reviews how the peritoneal fluid microenvironment and its immune/prostanoid components may contribute to endometriosis-associated pelvic pain and infertility.

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Abstract

Endometriosis is frequently found in patients with infertility and pelvic pain. It is estimated that 30% to 40% of women with infertility have endometriosis1. Dysmenorrhoea, dyspareunia, back and rectal pain are common complaints in women with endometriosis2. The relationship of endometriosis to pelvic pain and infertility is clearly evident, with disease resulting in extensive scarring and fixation of the adnexa, or with extensive distortion of ovarian anatomy by endometriomas. Infertility may occur when endometriosis on the ovarian capsule interferes with the ovulatory process and ovum pick-up. Preview Unable to display preview. Download preview PDF. Similar content being viewed by others

References

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Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3864-2_5 Download citation DOI: https://doi.org/10.1007/978-94-011-3864-2_5 Publisher Name: Springer, Dordrecht Print ISBN: 978-94-010-5719-6 Online ISBN: 978-94-011-3864-2 eBook Packages: Springer Book Archive

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