Prostaglandins and Endometriosis
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Endometriotic tissue in vitro produced prostacyclin and thromboxane A2 metabolites, though anti-prostaglandin drugs did not relieve symptoms in patients.
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Abstract
To study the production of prostacyclin (PGI2) and thromboxane A2 (TxA2) in endometriosis in vitro, samples of endometriotic tissue taken during operation from 6 women were superfused for 4.5 hours in 95% O2/5% CO2 at 37 degrees C, and the stable metabolites of PGI2 (=6-keto-PGF1 alpha), and TxA2 (=TxB2) were measured by radioimmunoassays from the superfusates. All samples studied produced 6-keto-PGF1 alpha in the range from 0.2 to 10.5 nanograms/gram of dry tissue/minute with a mean of 3.6 ng/g/min during the whole experiment. TxB2 was also released by each sample at rates between 0.2 and 11.9 ng/g/min (mean 2.6 ng/g/min). The production of these prostanoids tended to be greater in the serosal (n = 2) than in the ovarian (n = 4) endometriosis. The addition of indomethacin of 10(-5) - 10(-3) moles/l to the superfusion medium inhibited concentration-dependently the synthesis of these prostanoids. Apart from these in vitro data implying the production of PGs in endometriosis, 18 patients with pelvic endometriosis sustained no relief for their endometriotic symptoms from the treatments with three anti-prostaglandins (acetylsalicylic acid, indomethacin, tolfenamic acid) in a double-blind, placebo-controlled trial.
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Cited by (39)
- Nonsteroidal anti-inflammatory drugs for pain in women with endometriosis 2017
- Endometriose: Pathogenese, Symptome und Diagnostik 2015
- Roles of regulatory T cells in endometriosis-associated infertility 2014
- Influence of Nerve Growth Factor in Endometriosis-Associated Symptoms 2011
- Semi-invasive Diagnosis of Endometriosis Doctoral Thesis 2010
- Endometriose und Nervenfasern 2010
- Molecular profiling of human endometrium and endometriosis 2010
- Endometriose und Nervenfasern Ist Endometriose durch den Nachweis von Nervenfasern im Endometrium diagnostizierbar 2010
- Nerve fibres in peritoneal endometriosis 2006
- ESHRE guideline for the diagnosis and treatment of endometriosis 2005
- High density of small nerve fibres in the functional layer of the endometrium in women with endometriosis 2005
- Adolescent Endometriosis 2003
- Peritoneal Endometriosis 2000
- Today's treatments: medical, surgical and in partnership 1999
- Endometriosis and Pelvic Pain 1998
- PATHOPHYSIOLOGY 1997
- Pathogenesis of Pelvic Pain in Endometriosis 1995
- Pathogenesis of Infertility in Endometriosis 1995
- A Risk Benefit Assessment of Drugs Used in the Treatment of Endometriosis 1994
- The Use of Arachidonic Acid in Some Gynaecological Disorders 1994
- A mid-luteal phase comparison of V76 peritoneal fluid volume and its content of PGF2α and PGE2 in women with minimal stage endometriosis and a normal pelvis 1994
- Prostaglandin Synthesis Inhibitors in Menorrhagia, Intrauterine Contraceptive Device‐Induced Side Effects and Endometriosis 1994
- Changing concepts of medical treatment of endometriosis 1993
- Biochemische Aspekte der Endometriose 1993
- Endometriosis 1993
- Biochemische Aspekte der Endometriose 1993
- Endometriosis 1993
- Correlation between dysmenorrheic severity and prostaglandin production in women with endometriosis 1992
- Treatment of endometriosis 1992
- The peritoneal environment in endometriosis 1991
- Menstrual symptoms in women with pelvic endometriosis 1991
- Endometriosis and infertility 1990
- Minimal/mild endometriosis and infertility. A review 1989
- Eicosanoids in primary dysmenorrhea, endometriosis and menstrual migraine 1989
- Peritoneal fluid eicosanoids in chronic pelvic pain 1989
- Uterine contractions in endometriosis: Effects of operative and danazol treatment 1988
- Endometriosis, Lesions of the Secondary Müllerian System, and Pelvic Mesothelial Proliferations 1987
- Endometriosis 1986
- Peritoneal fluid 6‐keto‐prostaglandin FL<sub>α</sub>, thromboxane B2 in endometriosis and unexplained infertility 1984
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