Correlation between dysmenorrheic severity and prostaglandin production in women with endometriosis

Haruki Koike, H Koike, Koike H, Hiromu Egawa, Egawa H, H Egawa, T Ohtsuka, Takashi Ohtsuka, Ohtsuka T, Yamaguchi M, Motoko Yamaguchi, M Yamaguchi, T Ikenoue, Tsuyomu Ikenoue, Ikenoue T, N Mori, Naoko Mori, Mori N
Prostaglandins, leukotrienes, and essential fatty acids · 1992 · vol. 46(2) , pp. 133–137 · doi:10.1016/0952-3278(92)90219-9 · PMID:1502250 · W2008109212
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This study investigated the relationship between the severity of dysmenorrhea and prostaglandin levels in women diagnosed with endometriosis.

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Abstract

The role of prostaglandins (PGs) in dysmenorrhea of endometriosis is poorly understood. The relationship between dysmenorrheic severity and prostaglandin production was investigated in endometriosis. Slices of normal myometrium, adenomyosis, normal ovary and endometrial cyst were incubated. 6-Keto-PGF1 alpha (a metabolite of PGI2), TXB2 (a metabolite of TXA2), PGF2 alpha, and PGE2 concentrations of the incubation medium were measured by RIA. The results showed that 6-keto-PGF1 alpha production in adenomyosis and endometrial cyst were significantly higher than those in normal myometrium and ovary. A direct relationship between the degree of dysmenorrheic severity and PGs production in tissue in endometriosis was observed.

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Condition tags

dysmenorrheaendometriosis

MeSH descriptors

Dysmenorrhea Endometriosis Prostaglandins 6-Ketoprostaglandin F1 alpha 6-Ketoprostaglandin F1 alpha Adult Dinoprost Dinoprost Dinoprostone Dinoprostone Dysmenorrhea Dysmenorrhea Endometriosis Endometriosis Female Humans Middle Aged Ovary Ovary Prostaglandins

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (22)

Cited by (50)

Source provenance

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