Localization of endothelial nitric oxide synthase messenger ribonucleic acid by in situ hybridization in ectopic endometrial tissue in patients with adenomyosis

J Hatazawa, H Ota, Hirotaka Ota, M Murata, Masanori Murata, Shinichi Igarashi, S Igarashi, Toshinobu Tanaka, T Tanaka
Reproduction, fertility, and development · 2001 · vol. 12(6) , pp. 283–287 · doi:10.1071/rd00074 · PMID:11451019 · W2126449644
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Endothelial NOS mRNA was localized by in situ hybridization in ectopic endometrial tissue of adenomyosis patients, revealing moderate expression in three cases, suggesting a possible relationship with pathologies.

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Abstract

This study was undertaken to determine the expression of endothelial nitric oxide synthase (NOS) mRNA in ectopic endometrium in adenomyosis. Endothelial NOS mRNA expression was investigated by in situ hybridization using a human endothelial NOS RNA probe. The subjects comprised six cases of adenomyosis, and 14 women with normal fecundity as controls. Specific expression of endothelial NOS mRNA was found in glandular and surface epithelial cells in eutopic endometrium throughout the menstrual cycle in all groups. It is noteworthy that the expression of endothelial NOS mRNA was moderately positive in ectopic endometrial tissues in three of the six cases of adenomyosis. In conclusion, the endothelial NOS mRNA expression seen in the ectopic endometrium suggests a possible relationship with the various pathologies associated with adenomyosis.

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Condition tags

mesh:D004715adenomyosis

MeSH descriptors

Endometriosis Endometriosis Endometrium Nitric Oxide Synthase Adult Base Sequence Case-Control Studies Endometriosis Endometrium Endometrium Female Humans In Situ Hybridization In Situ Hybridization Middle Aged Molecular Sequence Data Nitric Oxide Synthase Nitric Oxide Synthase Type III Reference Values

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (25)

Cited by (5)

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