Expression of γδT Cells and Adhesion Molecules in Endometriotic Tissue in Patients With Endometriosis and Adenomyosis

Hirotaka Ota, H Ota, S Igarashi, Toshinobu Tanaka, T Tanaka
American journal of reproductive immunology (New York, N.Y. : 1989) · 1996 · vol. 35(5) , pp. 477–482 · doi:10.1111/j.1600-0897.1996.tb00128.x · PMID:8738719 · W2106276996
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Endometriotic and adenomyotic tissues showed increased expression of gamma delta T cells, adhesion molecules, and HLA antigens on glandular cells compared to controls.

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Abstract

PROBLEM: Are T cell subsets including gamma delta T cells. HLA antigens or adhesion molecules, expressed in eutopic and ectopic endometria in patients with endometriosis and adenomyosis? METHODS: Subjects consisted of 23 patients with adenomyosis and 21 patients with endometriosis. Controls consisted of 15 patients with adenomyoma and 42 infertile women without habitual abortion and autoimmune diseases. Staining of the glandular cells in eutopic and ectopic endometria or T lymphocyte subsets or macrophages in the stroma were analyzed immunohistochemically to localize the expression of the antigens. RESULTS: Immunohistochemical analysis revealed significantly increased expression of the antigens, particularly of the number of gamma delta T cells in the stroma and adhesion molecules and HLA antigens on the glandular cells in eutopic and ectopic endometria, compared with materials from patients with adenomyoma and infertile patients. CONCLUSION: It is likely that three distinct pathways of cell-cell interactions are activated in patients with endometriosis or adenomyosis.

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Condition tags

mesh:D004715endometriosisadenomyosis

MeSH descriptors

Cell Adhesion Molecules Endometriosis HLA Antigens Macrophages Receptors, Antigen, T-Cell, gamma-delta T-Lymphocyte Subsets Cell Adhesion Molecules Endometriosis Female HLA Antigens Humans Hysterectomy Macrophages Ovarian Cysts Receptors, Antigen, T-Cell, gamma-delta Staining and Labeling T-Lymphocyte Subsets

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