Effect of danazol on the immunocompetent cells in the eutopic endometrium in patients with endometriosis: a multicenter cooperative study

Ota H, Hirotaka Ota, H. Ota, S. Igarashi, Shinichi Igarashi, Igarashi S, Hayakawa M, Masaaki Hayakawa, M Hayakawa, Toshihiko Matsui, Matsui T, T Matsui, Hidenori Tanaka, Tanaka H, H Tanaka, T Tanaka, Tanaka T, Toshinobu Tanaka
Fertility and sterility · 1996 · vol. 65(3) , pp. 545–551 · doi:10.1016/s0015-0282(16)58151-5 · PMID:8774284 · W2416020933
article OA: closed CC0 ⤵ 37 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This multicenter study investigated the impact of danazol treatment on immunocompetent cells within the eutopic endometrium of patients diagnosed with endometriosis.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

ObjectiveTo assess the effects of danazol on immunocompetent cells, human leukocyte antigen (HLA) expression, and adhesion molecules in the eutopic endometrium of patients with endometriosis.DesignAntigens were localized immunohistochemically in the endometria, before treatment and during treatment (2 months later).ParticipantsTen patients with laparoscopically proven endometriosis who consented to participate in this study were treated with 400 mg/d of danazol for 4 months. Forty-two infertile patients without endometriosis or adenomyosis served as controls.ResultsImmunohistochemical analysis revealed significantly increased expression of the T cell subsets, macrophages, adhesion molecules, and HLA antigens in eutopic endometrium in patients with endometriosis compared with the infertile group. Treatment with danazol reduced the number of cells in T cell subsets, adhesion molecules, or HLA antigen expression, especially of gamma delta T cells, to 39.5% of the pretreatment value in patients with endometriosis.ConclusionsDanazol had an immunomodulatory effect on the autoimmune response in endometrium associated with endometriosis.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Danazol Endometriosis Endometrium T-Lymphocytes Adult Cell Adhesion Molecules Cell Adhesion Molecules Danazol Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Female HLA Antigens HLA Antigens Humans Immunohistochemistry Infertility, Female

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (31)

Cited by (37)

Source provenance

europepmc
last seen: 2026-08-06T06:07:45.168820+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:11:02.671803+00:00
License: CC0 · commercial use OK