Effect of danazol on the immunocompetent cells in the eutopic endometrium in patients with endometriosis: a multicenter cooperative study

Ota H, Hirotaka Ota, H. Ota, S. Igarashi, Shinichi Igarashi, Igarashi S, Hayakawa M, Masaaki Hayakawa, M Hayakawa, Toshihiko Matsui, Matsui T, T Matsui, Hidenori Tanaka, Tanaka H, H Tanaka, T Tanaka, Tanaka T, Toshinobu Tanaka
Fertility and sterility · 1996 · vol. 65(3) , pp. 545–551 · doi:10.1016/s0015-0282(16)58151-5 · PMID:8774284 · W2416020933
Non-randomised trial OA: closed CC0 ⤵ 37 in-corpus citations
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This multicenter study investigated the impact of danazol treatment on immunocompetent cells within the eutopic endometrium of patients diagnosed with endometriosis.

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Abstract

OBJECTIVE: To assess the effects of danazol on immunocompetent cells, human leukocyte antigen (HLA) expression, and adhesion molecules in the eutopic endometrium of patients with endometriosis. DESIGN: Antigens were localized immunohistochemically in the endometria, before treatment and during treatment (2 months later). PARTICIPANTS: Ten patients with laparoscopically proven endometriosis who consented to participate in this study were treated with 400 mg/d of danazol for 4 months. Forty-two infertile patients without endometriosis or adenomyosis served as controls. RESULTS: Immunohistochemical analysis revealed significantly increased expression of the T cell subsets, macrophages, adhesion molecules, and HLA antigens in eutopic endometrium in patients with endometriosis compared with the infertile group. Treatment with danazol reduced the number of cells in T cell subsets, adhesion molecules, or HLA antigen expression, especially of gamma delta T cells, to 39.5% of the pretreatment value in patients with endometriosis. CONCLUSIONS: Danazol had an immunomodulatory effect on the autoimmune response in endometrium associated with endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Danazol Endometriosis Endometrium T-Lymphocytes Adult Adult Cell Adhesion Molecules Cell Adhesion Molecules Cell Adhesion Molecules Danazol Danazol Endometriosis Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Endometrium Female

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (31)

Cited by (37)

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