Immunosuppressive effects of danazol in vitro

J A Hill, Hill JA, Joseph A. Hill, Robert L. Barbieri, Barbieri RL, R L Barbieri, Deborah J. Anderson, Anderson DJ, D J Anderson
Fertility and Sterility · 1987 · vol. 48(3) , pp. 414–418 · doi:10.1016/s0015-0282(16)59408-4 · PMID:3622794 · W191974625
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Danazol was observed to suppress T-cell proliferation and IL-2 production in vitro.

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Abstract

The effects of danazol on leukocyte activation in vitro were compared with those of other known immunosuppressive steroids. Danazol at a concentration of 10(-6) M, the systemic level in women taking 600 mg/day, significantly inhibited lymphocyte proliferation in cultures activated by T-cell mitogens (Concanavalin A and phytohemagglutinin) and allogeneic mixed lymphocyte culture (MLC). Comparable immunosuppressive effects were achieved in these assay systems with dexamethasone at a concentration of 10(-8) M, and with cortisol and progesterone at a concentration of 10(-6) M. Physiologic concentrations of estradiol and testosterone did not significantly affect these immunologic test systems. These studies provide evidence that danazol is immunosuppressive. It is possible that immunosuppressive effects contribute to the efficacy of this drug in the treatment of endometriosis and autoimmune disorders.

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MeSH descriptors

Danazol Immunosuppression Therapy Pregnadienes Analysis of Variance Cell Division Cell Division Culture Media Danazol Dose-Response Relationship, Drug Estradiol Estradiol Female Hydrocortisone Hydrocortisone In Vitro Techniques Lymphocyte Activation Lymphocyte Activation Male Monocytes Monocytes

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