The immune system in endometriosis

Endometriosis is a poorly understood disease of unknown aetiology and histogenesis. It affects women as well as menstruating female primates of other species. The disease is characterized by ectopic growth and function of endometrial cells. Current data indicate that endometriosis begins with retrograde transport through the fallopian tubes into the peritoneal cavity of endometrial cells or fragments desquamated during the menstrual period. These cells (or tissue fragments) then implant, proliferate and develop into characteristic endometriotic lesions. Under cyclic stimulation of the ovarian hormones, ectopic endometrial cells undergo similar cyclic changes to those of the uterine endometrium. From the peritoneal cavity, endometriosis may spread through lymphatic and vascular channels into distant locations. Alternatively, endometrial cells from the uterus may disseminate systemically into the pelvic cavity and distant locations. It is unclear why, in some women, endometrial cells are transported through lymphatic and vascular channels to various parts of the body, and why they are allowed to implant and function in the ectopic sites. In many respects, this process resembles metastases of neoplastic cells and is the reason why endometriosis in the past has been referred to as ‘a benign cancer’. Preview Unable to display preview. Download preview PDF. Similar content being viewed by others

Sampson, J.A. (1925). Heterotropic or misplaced endometrial tissue. Am. J. Obstet. Gynecol., 10, 649 Bartosik, D., Jacobs, S.L. and Kelly, L.J. (1986). Endometrial tissue in peritoneal fluid. Fertil. Steril., 46, 796–800 Wood, D.H., Yochmowitz, M.G., Salmon, Y.L., Eason, R.L. and Boster, R.A. (1983). Proton irradiation and endometriosis. Aviat. Space Environ. Med., 54, 718–724 Campbell, J.S., Wong, J., Tryphonas, L., Arnold, D.L., Nera, E., Cross, B. and LaBossiere, E. (1985). Is simian endometriosis an effect of immunotoxicity? Presented at the Annual Meeting, Ontario Association of Pathology, October 4, London, Ontario Gleicher, N., El-Roeiy, A., Confino, E. and Friberg, J. (1987). Abnormal autoantibodies in endometriosis: Is endometriosis an autoimmune disease? Obstet. Gynecol., 70, 115–122 Dmowski, W.P., Gebel, H.M. and Rawlins, R.G. (1989). Immunologic aspects of endometriosis. Obstet. Gynecol. Clin. North Am., 16, 93–103 Engleman, E.G., Warnke, R., Fox, R.I., Dilley, S., Benili, C.J. and Levy, R. (1981). Studies of a human T lymphocyte antigen recognized by a monoclonal antibody. Proc. Natl Acad. Sci., USA, 78, 1791–1795 Morimoto, C., Letvin, N., Boyd, A., Hagan, M., Brown, H., Kornacki, M. and Schlossman, S.F. (1985). The isolation and characterization of the human helper inducer cell subset. J. Immuno., 134, 3762–3769 Morimoto, G, Letvin, N., Distaso, J., Aldrich, W. and Schlossman, S.F. (1985). The isolation and characterization of the human suppressor inducer T cells subset. J. Immunol., 134, 1508–1515 Sanders, M.E., Makgoba, M.W. and Shaw, S. (1987). Human naive and memory T cells. Immunol. Today, 1, 1–3 Damle, N.K. and Engleman, E.G. (1983). Immunoregulatory T cells circuits in man: alloantigen-primed T cells activate alloantigen-specific suppressor T cells in the absence of the initial antigen stimulus. J. Exp. Med., 158, 159–173 Landay, A., Gartland, G.L. and Clemant, L. (1983). Characterization of a phenotypically distinct subpopulation of Leu 2+ cells which suppress T cell proliferation responses. J. Immunol., 131, 2757–2761 Stashenko, P., Nadler, L.M., Hardy, R. and Scholssman, S.F. (1980). Characterization of human B lymphocyte specific antigen. J. Immunol., 125, 1678–1685 Gadol, N. and Ault, K.A. (1986). Phenotypic and functional characterization of human Leu 1 (CD5) B cells. Immunol Rev., 93, 23–24 Lydyard, P.M., Youinou, P.Y. and Cooke, A. (1987). CD5-positive B cells in rheumatoid arthritis and chronic lymphocytic leukemia. Immunol. Today, 8, 37–38 Johnston, R. (1988). Monocytes and macrophages. N. Engl. J. Med., 318, 747–752 Basham, T., Smith, W., Lanier, L., Morhenn, U. and Merigan, T. (1984). Regulation of expression of class II major histocompatibility antigens on human peripheral blood monocytes and Langerhans cells by interferon. Human Immunol., 10, 83–93 Ades, E. and Lopez, C. (eds.) (1989). Natural Killer Cells and Host Defense. (San Francisco: Karger) Cascon, P., Zoumbos, N. and Young, N. (1986). Analysis of natural killer cells in patients with aplastic anemia. Blood, 67, 1349–1355 Bray, R.A., Gottschalk, L.R., Landay, A.L. and Gebel, H.M. (1987). Differential surface marker expression in patients with CD 16+ lymphoproliferative disorders: In vivo model for NK differentiation. Human Immunol., 19, 105–115 Miller, J.F.A.P., Morahan, G. and Allison, J. (1989). Immunological tolerance; New approaches using transgenic mice. Immunol. Today, 10, 53–57 Kappler, J.W., Roehm, N. and Marrack, P. (1987). T cell tolerance by clonal elimination in the thymus. Cell, 49, 273–280 Sha, W.C., Nelson, C.S., Newberry, R.D., Kranz, D.M., Russell, J.H. and Loh, D.Y. (1988). Positive and negative selection of an antigen receptor on T cells in transgenic mice. Nature, 336, 73–76 Goodnow, C.C., Crosbie, J., Adelstein, S., Lavoie, T.B., Smith-Gill, S.J., Brink, R.A., Pritchard-Briscoe, H., Wotherspoon, J.S., Loblay, R.H., Raphael, K., Trent, R.J. and Basten, A. (1988). Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice. Nature, 334, 676–682 Kisielow, P., Bluthmann, H., Staerz, U.D., Steinmetz, M. and von Boehmer, H. (1988). Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4 + 8 + thymocytes. Nature, 333, 742–746 Arnold, B., Dill, O., Kublbeck, G., Jatsch, L., Simon, M.M., Tucker, J. and Hammerling, G.J. (1988). Alloreactive immune responses of transgenic mice expressing a foreign transplantation antigen in a soluble form. Proc. Natl Acad. Sci., USA, 85, 2269–2273 Steele, R.W., Eichberg, J.W., Heberling, R.L., Kalter, S.S. and Kniker, W.T. (1977). Correlation of mixed lymphocyte reactivity and skin graft rejection in nonhuman primates. J. Med. Primatol., 6, 119–126 Shirai, M., Matsushita, S., Kagayama, M., Ichijo, S. and Takeuchi, M. (1966). Histological changes of the scrotal testis in unilateral cryptorchidism. Tohoku J. Exp. Med., 90, 363–373 Weksler, M.E., Moody, C.E. and Kozak, R.W. (1981). The autologous mixed lymphocyte reaction. Adv. Immunol., 31, 271–312 Engleman, E.G., Benike, C.J., Hoppe, R.T., Kaplan, H.S. and Berberich, F.R. (1980). Autologous mixed lymphocyte reaction in patients with Hodgkin’s disease. Evidence for a T-cell defect. J. Clin. Invest., 66, 149–158 Sakane, T., Steinberg, A.P. and Green, I. (1978). Failure of autologous mixed lymphocyte reactions between T and non-T cells in patients with systemic lupus erythematosus. Proc. Natl Acad. Sci, USA, 75, 3464 Startseva, N.V. (1980). Clinico-immunological aspects of genital endometriosis. Akush. Ginekol. (Mosk.), 3, 23–26 Weed, J.C. and Arguembourg, P.C. (1980). Endometriosis: can it produce an autoimmune response resulting in infertility? Clin. Obstet. Gynecol., 23, 885–893 Mathur, S., Peress, M.R., Williamson, H.O., Youmans, C.D., Maney, S.A., Garvin, A.J., Rust, P.F. and Fudenberg, H.H. (1982). Autoimmunity to endometrium and ovary in endometriosis. Clin. Exp. Immunol., 50, 259–266 Mathur, S., Chihal, H.J., Homm, R.J., Garza, D.E., Rust, P.F. and Williamson, H.O. (1988). Endometrial antigens involved in the autoimmunity of endometriosis. Fertil. Steril., 50, 860–863 Badawy, S.Z., Cuenca, V., Stitzel, A., Jacobs, R.D. and Tomar, R.H. (1984). Autoimmune phenomena in infertile patients with endometriosis. Obstet. Gynecol., 63, 271–275 Kreiner, D., Fromowitz, F.B., Richardson, D.A. and Kenigsberg, D. (1986). Endometrial immunofluorescence associated with endometriosis and pelvic inflammatory disease. Fertil. Steril., 46, 243–245 Saifuddin, A., Buckley, C.H. and Fox, H. (1983). Immunoglobulin content of the endometrium in women with endometriosis. Int. J. Gynecol. Pathol., 2, 255–263 Wild, R.A. and Shivers, C.A. (1985). Antiendometrial antibodies in patients with endometriosis. Am. J. Reprod. Immunol. Microbiol., 8, 84–86 Cowchock, S., Smith, J.B. and Gocial, B. (1986). Autoantibodies to phospholipids and nuclear antigens in patients with repeated abortions. Am. J. Obstet. Gynecol., 155, 1002–1010 Gleicher, N., El-Roeiy, A., Confino, E. and Friberg, J. (1987). Autoantibodies in patients with unexplained infertility and recurrent pregnancy loss (abstract 249). Presented at the 34th Annual Meeting, Society for Gynecologic Investigation, March 18–21, Atlanta, p. 153 El-Roeiy, A., Dmowski, W.P., Gleicher, N., Radwanska, E., Harlow, L., Binor, Z., Tummon, I. and Rawlins, R.G. (1988). Danazol but not gonadotropin-releasing hormone agonist suppresses autoantibodies in endometriosis. Fertil. Steril., 50, 864–871 Meek, S.C., Hodge, D.D. and Musich, J.R. (1988). Autoimmunity in infertile patients with endometriosis. Am. J. Obstet. Gynecol., 158, 1365–1373 Steele, R.W., Dmowski, W.P. and Marmer, D.J. (1984). Immunologic aspects of human endometriosis. Am. J. Reprod. Immunol., 6, 33–36 Pittaway, D.E. (1989). CA-125 in women with endometriosis. Obstet. Gynecol Clin. North Am., 16, 273–252 Dmowski, W.P., Steele, R.W. and Baker, G.F. (1981). Deficient cellular immunity in endometriosis. Am. J. Obstet. Gynecol., 141, 377–383. Gleicher, N., Dmowski, W.P., Siegel, I., Liu, T.L., Friberg, J., Radwanska, E. and Toder, V. (1984). Lymphocyte subsets in endometriosis. Obstet. Gynecol., 63, 463–466 Badawy, S.Z., Cuenca, V., Stitzel, A. and Tice, D. (1987). Immune rosettes of T and B lymphocytes in infertile women with endometriosis. J. Reprod. Med., 32, 194–197 Halme, J., Becker, S. and Wing, R. (1984). Accentuated cyclic activation of peritoneal macrophages in patients with endometriosis. Am. J. Obstet. Gynecol., 148, 85–90 Haney, A.F., Muscato, J.J. and Weinberg, J.B. (1981). Peritoneal fluid cell populations in infertility patients. Fertil. Steril., 35, 696–698 Zeller, J.M., Henig, I., Radwanska, E. and Dmowski, W.P. (1987). Enhancement of human monocyte and peritoneal macrophage chemiluminescence activities in women with endometriosis. Am. J. Reprod. Immunol. Microbiol., 13, 78–82 Fakih, H., Baggett, B., Holtz, G., Tsang, K.Y., Lee, J.C. and Williamson, H.O. (1987). Interleukin-1: a possible role in the infertility associated with endometriosis. Fertil. Steril., 47, 213–217 Kauma, S., Clark, M.R., White, C. and Halme, J. (1988). Production of fibronectin by peritoneal macrophages and concentration of fibronectin in peritoneal fluid from patients with or without endometriosis. Obstet. Gynecol., 72, 13–18 Parvizi, S.T., Jensen, P., DeCherney, A., Polan, M.L. and Comite, F. (1988). Elevated interleukin-1 (IL-1) synthesis by peripheral monocytes in endometriosis (abstract 450). Presented at the 35th Annual Meeting, Society for Gynecologic Investigation, March 17–20, Baltimore, p. 284. Halme, J., Becker, S. and Haskill, S. (1987). Altered maturation and function of peritoneal macrophages: possible role in pathogenesis of endometriosis. Am. J. Obstet. Gynecol., 156, 783–789 Ahn, Y.S., Harrington, W.J., Simon, S.R., Mylvaganam, R., Pall, L.M. and So, A.G. (1983). Danazol for the treatment of idiopathic thrombocytopenic purpura. N. Engl. J. Med., 308, 1396–1399 Agnello, V., Pariser, K., Gell, J., Gelfand, J. and Turksoy, R.N. (1983). Preliminary observations on danazol therapy of systemic lupus erythematosus: effects on DNA antibodies, thrombocytopenia and complement. J. Rheumatol., 10, 682–687 Gelfand, J.A., Sherins, R.J., Alling, D.W. and Frank, M.M. (1976). Treatment of hereditary angioedema with danazol: Reversal of clinical and biochemical abnormalities. N. Engl. J. Med., 295, 1444–1448 Gralnick, H.R. and Rick, M.E. (1983). Danazol increases Factor VIII and Factor IX in classic hemophilia and Christmas disease. N. Engl. J. Med., 308, 1393–1395 Mylvaganam, R., Ahn, Y.S., Harrington, W.J. and Kim, C.I. (1987). Immune modulation by danazol in autoimmune thrombocytopenia. Clin. Immunol. Immunopathol., 42, 281–287 Hill, J.A., Barbieri, R.L. and Anderson, D.J. (1987). Immunosuppressive effects of danazol in vitro. Fertil. Steril., 48, 414–418 Grimes, D.A., LeBolt, S.A., Grimes, K.R. and Wingo, P.A. (1985). Systemic lupus erythematosus and reproductive function: a case control study. Am. J. Obstet. Gynecol., 153, 179–186 Dmowski, W.P., Braun, D., Gebel, H., Rotman, C. and Madanes, A. Peripheral blood monocyte (PBM) and peritoneal macrophage (PM) cytotoxicity in women with endo metriosis and the effect of danazol. 46th Annual Meeting of the American Fertility Society, Washington, D.C., October, 1990 Braun, D.P., Harris, J.E. and Rubenstein, M. (1984). Relationship of arachidonic acid metabolism to indomethacin sensitive immunoregulatory function and lymphocyte PGE sensitivity and peripheral blood mononuclear cells of disseminated solid tumor cancer patients. J. Immunol. Pharmacol., 6(3), 227–236 Editor information Editors and Affiliations Rights and permissions Copyright information © 1991 Springer Science+Business Media Dordrecht About this chapter Cite this chapter Dmowski, W.P., Braun, D., Gebel, H. (1991). The immune system in endometriosis. In: Thomas, E.J., Rock, J.A. (eds) Modern Approaches to Endometriosis. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3864-2_6 Download citation DOI: https://doi.org/10.1007/978-94-011-3864-2_6 Publisher Name: Springer, Dordrecht Print ISBN: 978-94-010-5719-6 Online ISBN: 978-94-011-3864-2 eBook Packages: Springer Book Archive

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