Immunoglobulin Content of the Endometrium in Women with Endometriosis
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Endometriosis is associated with increased interstitial and epithelial immunoglobulin (IgG and IgA) deposition in the endometrium, with IgG deposition supporting the autoantibody hypothesis.
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Abstract
A study of the immunoglobulin content of endometria from women with and without endometriosis has shown that, in women with endometriosis, both IgG and IgA are more commonly found in the interstitium of the endometrial stroma than is the case in endometria from women without this disease. It is thought that the increased stromal content of immunoglobulins in endometriosis is simply a passive reflection of elevated serum IgG and IgA levels. Both the incidence and extent of positive endometrial glandular epithelial staining for IgG and IgA are markedly increased in women with endometriosis: the excess of intraepithelial IgA is probably simply a consequence of the excess of stromal IgA, but the increased epithelial staining for IgG lends support to the concept that many women with endometriosis develop autoantibodies directed against an endometrial epithelial antigen. No relationship could be demonstrated, however, between IgG deposition in the endometrium of women with endometriosis and a history of infertility.
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Cited by (32)
- Endometriosis and autoimmunity: Can autoantibodies be used as a non-invasive early diagnostic tool? 2021
- Differences in C-type lectin receptors and their adaptor molecules in the peritoneal fluid of patients with endometriosis and gynecologic cancers 2018
- Decreased Bcl-6 and increased Blimp-1 in the peritoneal cavity of patients with endometriosis 2015
- Increased Expression of Pattern Recognition Receptors and Nitric Oxide Synthase in Patients with Endometriosis 2013
- Endometriosis and Autoimmunity 2011
- Pathophysiology of Endometriosis-Associated Infertility 1999
- Levels of Transferrin and Alpha 2-HS Glycoprotein in Women with and without Endometriosis 1999
- Immunology of endometriosis 1999
- Effects of Antibodies to Transferrin and Alpha 2‐HS Glycoprotein on In Vitro Sperm Motion: Implications in Infertility Associated with Endometriosis 1998
- Is adenomyosis an immune disease? 1998
- Immunological aspects of endometriosis 1996
- Prevalence of Endometriosis in Rhesus (Macaca mulatta) Monkeys Ingesting PCB (Aroclor 1254): Review and Evaluation 1996
- Prevalence of Endometriosis in Rhesus (<i>Macaca mulatta</i>) Monkeys Ingesting PCB (Aroclor 1254): Review and Evaluation 1996
- Antibodies to Endometrial Transferrin and Alpha 2‐Heremans Schmidt (HS) Glycoprotein in Patients With Endometriosis 1996
- Anti-endometrial antibodies in women measured by an enzyme-linked immunosorbent assay 1996
- Immunological aspects of endometriosis 1995
- Target Antigen(s) in Endometrial Autoimmunity of Endometriosis 1995
- Treatment of Infertility Associated With Endometriosis 1995
- Pathogenesis of Infertility in Endometriosis 1995
- Immunosuppressive effect of danazol on lymphocyte-mediated cytotoxicity toward human endometrial stromal cells 1994
- 3 Endometriosis: The host response 1993
- 4 Markers for endometriosis 1993
- Danazol Suppresses Both Spontaneous and Activated Human Lymphocyte‐Mediated Cytotoxicity 1992
- The immune system in endometriosis 1991
- Immunologie Aspects of Endometriosis 1989
- Endometrial antigens involved in the autoimmunity of endometriosis 1988
- Autoimmunity in infertile patients with endometriosis 1988
- Endometriosis, Lesions of the Secondary Müllerian System, and Pelvic Mesothelial Proliferations 1987
- Epithelial Localization of Antiendometrial Antibodies Associated With Endometriosis 1987
- Endometriosis 1986
- An endometrial antibody assay in the clinical diagnosis and management of endometriosis 1986
- Antiendometrial Antibodies in Patients With Endometriosis 1985
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