Immunoglobulin Content of the Endometrium in Women with Endometriosis

A. Saifuddin, Saifuddin A, Buckley Ch, C. H. Buckley, Fox H, H. Fox
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists · 1983 · vol. 2(3) , pp. 255–263 · doi:10.1097/00004347-198303000-00003 · PMID:6196308 · W2037009032
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-14 ⓘ

Endometriosis is associated with increased interstitial and epithelial immunoglobulin (IgG and IgA) deposition in the endometrium, with IgG deposition supporting the autoantibody hypothesis.

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This study compared the immunoglobulin content in endometrial tissue from women with and without endometriosis, revealing significantly higher levels of IgG and IgA within the stromal interstitium of affected patients. While the increased stromal immunoglobulins likely reflect elevated serum levels, the marked increase in intraepithelial staining for both IgG and IgA suggests a distinct local process, particularly regarding autoantibodies against endometrial epithelial antigens. The researchers noted that despite these findings, there was no demonstrable relationship between endometrial IgG deposition and a history of infertility in the studied population. This paper is centrally about endometriosis — specifically examining the immunological profile and immunoglobulin deposition patterns within the endometrium of affected women.

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Abstract

A study of the immunoglobulin content of endometria from women with and without endometriosis has shown that, in women with endometriosis, both IgG and IgA are more commonly found in the interstitium of the endometrial stroma than is the case in endometria from women without this disease. It is thought that the increased stromal content of immunoglobulins in endometriosis is simply a passive reflection of elevated serum IgG and IgA levels. Both the incidence and extent of positive endometrial glandular epithelial staining for IgG and IgA are markedly increased in women with endometriosis: the excess of intraepithelial IgA is probably simply a consequence of the excess of stromal IgA, but the increased epithelial staining for IgG lends support to the concept that many women with endometriosis develop autoantibodies directed against an endometrial epithelial antigen. No relationship could be demonstrated, however, between IgG deposition in the endometrium of women with endometriosis and a history of infertility.
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Immunoglobulin Content of the Endometrium in Women with Endometriosis - A. Saifuddin - C. H. Buckley - H. Fox A study of the immunoglobulin content of endometria from women with and without endometriosis has shown that, in women with endometriosis, both 1gG and IgA are more commonly found in the interstitium of the endo-metrial stroma than is the case in endometria from women without this disease. It is thought that the increased stromal content of immunoglobulins in endometriosis is simply a passive reflection of elevated serum IgG and IgA levels. Both the incidence and extent of positive endometrial glandular epithelial staining for IgG and IgA are markedly increased in women with endometriosis: the excess of intraepithelial IgA is probably simply a consequence of the excess of stromal IgA, but the increased epithelial staining for IgG lends support to the concept that many women with endometriosis develop autoantibodies directed against an endometrial epithelial antigen. No relationship could be demonstrated, however, between IgG deposition in the endometrium of women with endometriosis and a history of infertility.

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Endometrium Immunoglobulin A Immunoglobulin G Endometriosis Endometrium Female Humans Immunoglobulin A Immunoglobulin G Immunoglobulin M Immunoglobulin M Infertility, Female Infertility, Female Ovary Ovary Staining and Labeling

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