Target Antigen(s) in Endometrial Autoimmunity of Endometriosis

Subbi Mathur, S Mathur, W J Butler, William J. Butler, H. Jane Chihal, H J Chihal, Keith Isaacson, K B Isaacson, Norbert Gleicher, N Gleicher
Autoimmunity · 1995 · vol. 20(4) , pp. 211–222 · doi:10.3109/08916939508995698 · PMID:7578883 · W2058814158
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This study identified specific, immunogenic endometrial antigens with molecular weights of 34, 46/48, 64, 94, and 120 kDa, particularly 64 kDa, which are auto-antibodies in patients with endometriosis.

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Abstract

OBJECTIVE: To obtain the molecular weights (MW) of endometrial antigens eliciting immunoglobulin (Ig) G auto-antibodies in all endometriosis patients irrespective of their place of origin or race, and to verify their specificity and immunogenicity. STUDY DESIGN AND RESULTS: We tested the serum and peritoneal fluid (P.F.) of 76 endometriosis patients and 24 controls from 4 cities against endometrial and implant antigens by Western blot analysis. Endometrial and implant antigens with MW of 34, 46/48, 64, 84, 94 and 120 kDa bound with IgG in serum and PF of most patients, but not the controls. Antigen(s) with MW of 64 kDa was reactive against serum or P.F. IgG of patients from all cities. Specificity: Endometrial and implant extracts did not react with monoclonal antibodies to WBC subsets and 5 sera with nuclear antibodies. Also, the presence of nuclear and endometrial antibodies did not correlate in 20 other patients with endometriosis. Immunogenicity: We immunized rabbits with the native and eluted (MW 29 to 68 kDa and > or = 68 kDa) endometrial and implant proteins. The antiserum had specific IgG binding to the same glandular epithelial antigens as those bound by the patient's serum. CONCLUSIONS: Endometrial antigens with MW of 34, 46/48, 64, 94 and 120 kDa, especially 64 kDa appear to be specific, immunogenic and relevant to endometrial autoimmunity in all patients with endometriosis.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Autoantigens Endometriosis Endometrium Adult Animals Autoantigens Autoantigens Autoimmunity Endometriosis Endometrium Female Humans Immunization Molecular Weight Rabbits

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