The pattern of cytokine mRNA expression in ovarian endometriomata
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This study found significantly increased mRNA expression of IL-1 alpha, IL-6, and IL-10 in ovarian endometriomata compared to normal ovarian tissue.
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Abstract
Intraovarian cytokines play a pivotal role in the normal growth and development of the ovarian follicle. The purpose of this study was to investigate the pattern of cytokine mRNA expression in ovarian endometriomata. A total of 10 patients with histologically confirmed endometriomata undergoing surgery formed the study group while nine patients undergoing sterilization with no evidence of a cyst in the ovary formed the control group. Biopsies of the ovary were obtained at surgery and stored in liquid nitrogen until processed by reverse transcription-polymerase chain reaction amplification to identify the presence of mRNA for interleukin (IL)-1, IL-2, IL-4, IL-6, IL-8, IL-10, IL-13, tumour necrosis factor-alpha (TNF-alpha), and interferon-gamma (IFN-gamma). IL-6 and IL-10 mRNA were expressed by nine and seven patients respectively in the endometriosis group compared with three and one patients in the control group; this difference was significant (P < 0.05). IL-1 alpha mRNA was expressed by seven of 10 patients with endometriosis but by only one of the control group; this was again significantly different (P < 0.04). Ovarian IL-2 and IL-4 mRNA were not expressed in either group. There was no significant difference in the expression of IL-8, IL-13, IFN-gamma and TNF-alpha mRNA in the two groups. These findings suggest that abnormal local expression of certain cytokines may contribute to the development of endometriomata.
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- Factores inmunogen�ticos asociados al desarrollo de endometriosis 2021
- Alterations in the invasive properties of peripheral blood monocytes from patients with endometriosis 2019
- Endometriosis 2013
- Ovarian endometrioma but not deep infiltrating endometriosis is associated with increased serum levels of interleukin-8 and interleukin-6 2012
- Clarithromycin and telithromycin increases interleukin-10 expression in the rat endometriosis model 2011
- Differential Expression of MicroRNAs between Eutopic and Ectopic Endometrium in Ovarian Endometriosis 2010
- Endometriosis 2009
- Biomarkers of endometriosis 2008
- Cytokine and chemokine expression in a rat endometriosis is similar to that in human endometriosis 2008
- Nuclear Factor-κB (NF-κB): An Unsuspected Major Culprit in the Pathogenesis of Endometriosis That Is Still at Large? 2006
- Changes in cytokine levels of patients with ovarian endometriosis after treatment with gonadotropin-releasing hormone analogue, ultrasound-guided drainage, and intracystic recombinant interleukin-2 2005
- Serum and cyst fluid levels of interleukin (IL) -6, IL-8 and tumour necrosis factor-alpha in women with endometriomas and benign and malignant cystic ovarian tumours 2003
- Analysis of an Interleukin-6 Gene Promoter Polymorphism in Women With Endometriosis Polymorphism in Women With Endometriosis By Pyrosequencing 2003
- The Role of Cytokines in Endometriosis* 2003
- Nitric oxide synthesis is increased in the endometrial tissue of women with endometriosis 2003
- Analysis of an interleukin-6 gene promoter polymorphism in women with endometriosis by pyrosequencing 2003
- Enhanced Activity of Cytosolic Phospholipase A2 in the Rat Uterus and Cervix around Parturition. 2002
- Endometriosis: Polymorphisms for Interleukin-1β (IL-1β)-511 Promoter, IL-1β Exon 5, and IL-1 Receptor Antagonist: Nonassociation with Endometriosis 2001
- Angiogenesis in Endometriosis 2001
- Peritoneal fluid concentrations of interleukin‐4 in relation to the presence of endometriosis, its stage and the phase of the menstrual cycle 2001
- High concentrations of the vascular endothelial growth factor and interleukin-8 in ovarian endometriomata 2000
- Production of Interleukins 1β, 6 and 8 and Tumor Necrosis Factor Alpha in Separated and Cultured Endometrial and Endometriotic Stromal and Epithelial Cells 2000
- Chemokines and human reproduction 1999
- Endometriosis: abnormal endometrium and dysfunctional immune response 1998
Source provenance
- europepmc
- last seen: 2026-06-22T06:15:23.361955+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-05-13T22:10:52.568893+00:00
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