Cytokine and chemokine expression in a rat endometriosis is similar to that in human endometriosis

Masakazu Umezawa, Umezawa M, Sakata C, Chika Sakata, Naomi Tanaka, Tanaka N, Kudo S, Sayaka Kudo, Tabata M, Masako Tabata, Ken Takeda, Takeda K, Ihara T, Tomomi Ihara, Masao Sugamata, Sugamata M
Cytokine · 2008 · vol. 43(2) , pp. 105–109 · doi:10.1016/j.cyto.2008.04.016 · PMID:18595729 · W2014353318
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This study examined cytokine and chemokine expression in a rat model of endometriosis and found it to be similar to that observed in human endometriosis.

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Abstract

The pathogenesis of endometriosis, a gynecologic disorder associated with infertility, appears to involve immune responses. However, the details involved have not been clarified. In this study, we analyzed expression levels of interleukin (IL)-6, IL-10, monocyte chemoattractant protein-1, eosinophil chemotactic protein, macrophage inflammatory protein-1alpha, and regulated on activation normal T cell expressed and secreted (RANTES) and CC chemokine receptor 1 in endometriotic lesions in a rat model in which endometrium is autotransplanted onto peritoneal tissue and found that they were remarkably increased, while those of IL-2, IL-4, and interferon-gamma were not. These results were obtained in a rat model induced by autologous, not allogeneic, transplantation of endometrial epithelium to the peritoneum. Expression of these factors is consistent with that of endometriosis in humans. Therefore, this model may be useful in the investigation of the pathogenesis and treatment of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Cytokines Endometriosis Animals Cytokines Cytokines Endometriosis Endometriosis Female Gene Expression Regulation Humans Rats Rats, Sprague-Dawley

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (52)

Cited by (32)

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