Increase of Activated Mast Cells in Human Endometriosis

Masao Sugamata, Tomomi Ihara, Ichiro Uchiide
American journal of reproductive immunology (New York, N.Y. : 1989) · 2005 · vol. 53(3) , pp. 120–125 · doi:10.1111/j.1600-0897.2005.00254.x · PMID:15727565 · W2158102618
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Mast cells were significantly more numerous and activated in endometriotic lesions compared to eutopic endometrium and normal uterine serosa from patients with and without endometriosis.

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Abstract

PROBLEM: The proliferation of stromal cells in endometriosis promotes extensive adhesion; therefore, the morphological analysis of stromal lesions is important in the investigation of the pathogenesis of endometriosis. METHOD OF STUDY: In this study, the morphological and numeric comparisons of degranulated mast cells were performed between endometriotic lesions and comparative regions (eutopic endometrium and normal uterine serosa) of patients with and without endometriosis. RESULTS: In cases of endometriosis, diffuse infiltration of numerous mast cells was observed throughout the stromal lesions. These mast cells exhibited degranulation, and scattered granules were also observed. In the eutopic endometrium and normal uterine serosa of both the endometriosis patients and the controls, mast cells were rarely detected. CONCLUSIONS: These results suggest that an abnormal immune response, specifically a hypersensitivity reaction, is strongly related to endometriosis; our findings will be helpful in the development of methods for the treatment of endometriosis.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Cell Degranulation Endometriosis Mast Cells Adult Cell Degranulation Endometriosis Female Humans Mast Cells Mast Cells Microscopy, Electron

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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