Complement Component 3 expressed by the endometrial ectopic tissue is involved in the endometriotic lesion formation through mast cell activation

Chiara Agostinis, Sonia Zorzet, Andrea Balduit, Gabriella Zito, Alessandro Mangogna, Paolo Macor, Federico Romano, Marco Toffoli, Beatrice Belmonte, Anna Martorana, Violetta Borelli, Giuseppe Ricci, Uday Kishore, Roberta Bulla
In: bioRxiv · 2020 · doi:10.1101/2020.11.19.389536 · W3101529268
preprint OA: green CC0 ⤵ 7 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

Complement component 3 produced by ectopic endometrial tissue drives endometriotic lesion formation by activating mast cells.

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Abstract

Abstract The pathophysiology of endometriosis (EM) is an excellent example of immune dysfunction, reminiscent of tumor microenvironment as well. Here, we report that an interplay between C3 and mast cells (MCs) is involved in the pathogenesis of ectopic EM. C3 is at the epicenter of the regulatory feed forward loop, amplifying the inflammatory microenvironment, in which the MCs are protagonists. Thus, C3 can be considered a marker of EM and its local synthesis can promote the engraftment of the endometriotic cysts. We generated a murine model of EM via injection of minced uterine tissue from a donor mouse, into the peritoneum of the recipient mice. The wild type mice showed greater amount of cyst formation in the peritoneum compared to C3 knock-out mice. This study offers an opportunity for novel therapeutic intervention in EM, a difficult to treat gynecological condition. Summary C3 produced by the endometriotic tissue is involved in the lesion development through mast cell activation

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Condition tags

endometriosis

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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