The intricate role of mast cell proteases and the annexin A1-FPR1 system in abdominal wall endometriosis

Rubens Paula, Antônio Hélio Oliani, Antonio H Oliani, Denise Cristina Mós Vaz-Oliani, Denise C M Vaz-Oliani, Solange C G P D'Ávila, Solange Corrêa Garcia Pires D'Ávila, Sônia Maria Oliani, Sonia M Oliani, Cristiane D Gil, Cristiane Damas Gil
Journal of molecular histology · 2014 · vol. 46(1) , pp. 33–43 · doi:10.1007/s10735-014-9595-y · PMID:25201101 · W1990732164
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-10 ⓘ

This study found increased mast cell chymase and co-upregulated annexin A1 and FPR1 expression in ectopic endometrium, suggesting their involvement in abdominal wall endometriosis development.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

This study compared ectopic endometrium from 18 women with abdominal wall endometriosis to eutopic endometrium from 10 women without endometriosis, assessing histologic differences and expression of mast cell proteases (tryptase and chymase), annexin A1 (ANXA1), and formyl peptide receptor 1 (FPR1) using histopathology, immunohistochemistry, and ultrastructural immunogold labeling. Endometriotic lesions showed an undifferentiated glandular morphology with increased inflammatory cell infiltration and a mast cell heterogeneity shift, including a significant increase in chymase-positive cells and endogenous chymase expression. The undifferentiated glandular pattern was associated with increased, co-localized ANXA1 and FPR1 in epithelial cells. This paper is centrally about endometriosis — specifically abdominal wall endometriosis and the mast cell chymase and ANXA1–FPR1 system in lesion development.

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Abstract

Endometriosis is a continuous and progressive disease with a poorly understood aetiology, pathophysiology and natural history. This study evaluated the histological differences between eutopic and ectopic endometria (abdominal wall endometriosis) and the expression of mast cell proteases (tryptase and chymase), annexin A1 (ANXA1) and formyl peptide receptor 1 (FPR1). Ectopic endometrium from 18 women with abdominal wall endometriosis and eutopic endometrium from 10 women without endometriosis were obtained. The endometrial samples were analysed by histopathology, immunohistochemistry and ultrastructural immunogold labeling to determine mast cell heterogeneity (tryptase and chymase positive cells) and the expression levels of ANXA1 and FPR1. Histopathological analysis of the endometriotic lesions showed a glandular pattern of mixed differentiation and an undifferentiated morphology with a significant influx of inflammatory cells and a change in mast cell heterogeneity, as evidenced by a significant increase in the number of chymase-positive cells and endogenous chymase expression. The undifferentiated glandular pattern of endometriotic lesions was positively associated with a marked increase and co-localization of ANXA1 and FPR1 in the epithelial cells. In conclusion, the co-upregulated expression of mast cell chymase and ANXA1–FPR1 system in ectopic endometrium suggests their involvement in the development of endometriotic lesions. Description

Keywords

Chymase, Endometrioma, Immunohistochemistry, Inflammation, Lipocortin-1, Transmission electron microscopy Language English Citation Journal of Molecular Histology, v. 46, n. 1, p. 33-43, 2015.

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Condition tags

endometriosis

MeSH descriptors

Annexin A1 Endometriosis Endometriosis Mast Cells Peptide Hydrolases Receptors, Formyl Peptide Abdominal Wall Abdominal Wall Adult Annexin A1 Annexin A1 Endometriosis Endometrium Endometrium Endometrium Female Gene Expression Humans Immunohistochemistry Mast Cells

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