[Sodium cromoglycate attenuates experimental endometriosis in rats by regulating mast cells].

Li-bo Zhu, Libo Zhu, Kaiqing Lin, Kai-qing Lin, Xinmei Zhang, Xin-mei Zhang, Jun Lin
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2015 · vol. 44(3) , pp. 278–84 · doi:10.3785/j.issn.1008-9292.2015.05.07 · PMID:26350008 · W1465446821
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

Sodium cromoglycate treatment in rats reduced mast cell degranulation and associated TNF-α and tryptase levels in an endometriosis model.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 ⓘ

The paper investigated whether sodium cromoglycate could attenuate experimentally induced endometriosis in rats, focusing on its effects on mast cells. In an animal model, the authors report that regulating mast cell activity was associated with reduced endometriosis-related pathology. A key limitation is that the findings are based on a rat experimental model and the text provided does not specify details such as the exact dosing regimen, sample size, or how mast cell changes were quantified. This paper is centrally about endometriosis—specifically, how sodium cromoglycate attenuates experimental endometriosis in rats by regulating mast cells.

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Abstract

OBJECTIVE: To investigate the effect of sodium cromoglycate on experimental endometriosis in rats. METHODS: Endometriosis model was established in 36 unpregnant female SD rats by transplanting autologous fragments of endometrium to the inner surface of the abdominal wall. The endometriotic lesions were measured by a second laparotomy 2 weeks after surgery. Then the rats were randomly divided into four groups (n=8 in each group) to receive intraperitoneal injection of different doses of sodium cromoglycate for 2 weeks: high-dose group (20 mg·kg⁻¹·d⁻¹); low-dose group (10 mg·kg⁻¹·d⁻¹); the negative control group and the blank control group. The animals were sacrificed and the size of the lesions were measured. The endometriosis model of SD rats was identified by HE staining and immunohistochemical staining of keratin and vimentin. The total number of mast cells and their degranulation were measured by Toluidine blue staining; the concentrations of TNF-α in serum were measured by enzyme linked immunosorbent assay; the concentrations of estradiol in serum were measured by enzyme immunoassay; the expression of tryptase and nerve growth factor (NGF) were measured by immunohistochemical staining. RESULTS: The number of activated mast cells (MC) by Toluidine blue staining in high-dose group was significantly lower than that in negative control group (P<0.05), and its ratio of degranulation/total number of MC was significantly lower than that in negative control group or blank control group (P<0.05). The serum TNF-α levels and tryptase expression in tissues in high-dose group were significantly lower than those in negative control group or blank control group (P0.05). CONCLUSION: Sodium cromoglycate can stabilize mast cells from degranulation, which may relieve the clinical symptoms of endometriosis by reducing TNF-α and tryptase levels.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Cromolyn Sodium Endometriosis Mast Cells Animals Cromolyn Sodium Disease Models, Animal Endometriosis Endometrium Endometrium Female Mast Cells Nerve Growth Factor Nerve Growth Factor Rats Rats, Sprague-Dawley Tryptases Tryptases Tumor Necrosis Factor-alpha Tumor Necrosis Factor-alpha

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