Annexin A1, FPR2/ALX, and inflammatory cytokine expression in peritoneal endometriosis

Lia Karina Volpato, Verônica Vargas Horewicz, Franciane Bobinski, Daniel Fernandes Martins, Anna Paula Piovezan, Piovezan AP
Journal of Reproductive Immunology · 2018 · vol. 129 , pp. 30–35 · doi:10.1016/j.jri.2018.08.002 · PMID:30096622 · W2887856804
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This study investigated the relationship between annexin A1, FPR2/ALX expression, and inflammatory cytokine levels in peritoneal endometriosis tissue.

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Abstract

To characterize Annexin A1 (ANXA1), FPR2/ALX and cytokines expression in peritoneal endometriosis and to clarify their role in its etiology, a cross-sectional study was performed with forty women in reproductive age (22 patients with endometriosis and 18 control women) that had undergone laparoscopic surgery. Peritoneal biopsy and fluid aspirations from endometriosis and control samples were analyzed for the expression of ANXA1, FPR2/ALX and cytokines. ANXA1 and FPR2 / ALX levels were measured by Western blotting and interleukin 1ß (IL-1β), interleukin 4 (IL-4), interleukin 6 (IL-6), and interleukin 10 (IL-10) levels were quantified by enzyme-linked immunosorbent assay (ELISA). The present study identified the presence in human peritoneal tissue of ANXA1 and FPR2 / ALX both in healthy condition and in women with peritoneal endometriosis, however, was lower in endometriosis samples than in control samples. By quantifying the IL-6 and IL-1β cytokines in the peritoneal fluid by ELISA, this study identified a higher IL-6 concentration in endometriosis group, but no significative difference in IL-1ß levels. The IL-4 and IL-10 levels could not be detected. These results indicate that the reduction of the inflammatory resolution mediators could be responsible for the inflammatory process perpetuation, maintenance and worsening of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Annexin A1 Ascitic Fluid Endometriosis Inflammation Mediators Interleukin-6 Peritoneum Receptors, Formyl Peptide Receptors, Lipoxin Adolescent Adult Annexin A1 Ascitic Fluid Cross-Sectional Studies Down-Regulation Endometriosis Female Humans Inflammation Mediators Interleukin-6 Peritoneum

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