Influence of progestin use on the IL-10 level in peritoneal endometriosis

Paula Medina Poeta Fermino, Lia Karina Volpato, Anna Paula Piovezan, Verônica Vargas Horewicz, Daniel Fernandes Martins, Rodrigo Dias Nunes
In: International journal of health sciences · 2022 · doi:10.53730/ijhs.v6ns1.7671 · W4281294935
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This study found that peritoneal endometriosis patients have higher IL-10 levels than controls, and progestin use significantly reduces these levels in peritoneal lavage.

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Abstract

Purpose: How can progestin influence the anti-inflammatory cytokine IL-10 level in the peritoneum with endometriosis? Methods: A cross-sectional study with a laboratory analysis carried out in tertiary hospitals in southern Brazil with clinical-demographic data compilation and sample collection of peritoneal lavage and a peritoneum biopsy from 40 patients — 22 with endometriosis (11 with progestin and 11 without it) and 18 in the control group — was conducted. For the sample analysis, the ELISA was performed, and a comparison of the average IL-10 concentrations by ANOVA followed by Bonferroni was carried out. Results: There was a higher concentration of IL-10 among patients with endometriosis compared to the control group (p ≤ 0.05), and statistical significance was observed with a reduction of IL-10 in the peritoneal lavage of patients with endometriosis in the use of progestin (8.1 ± 7.4 pg/ml) compared to those with endometriosis without using progestin (17.9 ± 10.5 pg/ml). Considering the disease stage, a higher level of IL-10 (p ≤ 0.05) was observed both in the initial stages (12.1 ± 10.5 pg/ml) and in advanced stages (15.4 ± 9.7 pg/ml) compared to the control (1.7 ± 1.8 pg/ml), which was significantly higher for advanced endometriosis.

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Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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