The Effect of Flavonoid from Extract of Phaleria Macrocarpa on Levels Il-2, Il-17a and Il-33 in Endometriosis Mice

Gema Alya Salsabila, Ana Paramita Prastiwi, Leni Ria Ariana, Sutrisno Sutrisno, Nurdiana Nurdiana, Nanik Setijowati, I Wayan Agung Indrawan, Diadjeng Setya Wardani, Maharani Maharani
In: Journal of Advanced Zoology · 2023 · vol. 44(3) , pp. 841–845 · doi:10.17762/jaz.v44i3.1156 · W4387848659
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

Flavonoids from Phaleria macrocarpa extract were found to reduce elevated levels of IL-2, IL-17a, and IL-33 in a mouse model of endometriosis.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-12 · read from full text ⓘ

The study investigated how flavonoids extracted from Phaleria macrocarpa affect inflammatory cytokines IL-2, IL-17A, and IL-33 in a mouse model of endometriosis. Using 40 female Mus musculus mice, the researchers formed eight groups including healthy controls and an untreated endometriosis group, then treated endometriosis mice with different flavonoid doses (3.75, 7.5, 11.2, and 15 mg/day), measuring cytokine levels via ELISA. Endometriosis increased IL-2, IL-33, and IL-17A compared with healthy mice, while Phaleria macrocarpa flavonoid treatment reduced these proinflammatory cytokine levels. This paper is centrally about endometriosis — it directly tests Phaleria macrocarpa flavonoids on IL-2, IL-17A, and IL-33 levels in endometriosis mice.

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Abstract

Endometriosis is a inflamatory disease especially in the state of reproductive age. Phaleria macrocarpa is a plant that has a population in Papua, Irian Jaya. Endometriosis therapies available have still many weakness, including being expensive, only relieving pain, and continuous treatment to prevent endometriosis from recurring. The fruit and seeds of the Phaleria macrocarpa have a wide range of important biological activities in the form of extracts such as antimicrobial, anti-inflammatory, and antioxidant activities. This aim of this was to analyze the effect of flavonoid from extract of phaleria macrocarpa on IL-2, IL-17A, and IL-33 levels in endometriosis mice. This research is using total of 40 female mice (Mus musculus) model endometriosis were grouped into 8 groups, including of healthy mice (without any treatment), the endometriosis group, and the endometriosis group treated flavonoids of Phaleria macrocarpa with dose of 3.75 mg/day; 7.5 mg/day; 11.2 mg/day; 15 mg/day. The level of IL-2, IL-17A, IL-33 were measured using the ELISA method. There was an increase in IL-2, IL-33, and IL17A levels in mice model of endometriosis. Flavonoid of Phaleria macrocarpa can reduce levels of proinflammatory cytokines such as IL-2, IL-33, and IL17A.
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The Effect of Flavonoid from Extract of Phaleria Macrocarpa on Levels Il-2, Il-17a and Il-33 in Endometriosis Mice DOI: https://doi.org/10.53555/jaz.v44i3.1156Keywords: Phaleria macrocarpa, flavonoid, endometriosis, IL-2, IL-17A, IL-33Abstract Endometriosis is a inflamatory disease especially in the state of reproductive age. Phaleria macrocarpa is a plant that has a population in Papua, Irian Jaya. Endometriosis therapies available have still many weakness, including being expensive, only relieving pain, and continuous treatment to prevent endometriosis from recurring. The fruit and seeds of the Phaleria macrocarpa have a wide range of important biological activities in the form of extracts such as antimicrobial, anti-inflammatory, and antioxidant activities. This aim of this was to analyze the effect of flavonoid from extract of phaleria macrocarpa on IL-2, IL-17A, and IL-33 levels in endometriosis mice. This research is using total of 40 female mice (Mus musculus) model endometriosis were grouped into 8 groups, including of healthy mice (without any treatment), the endometriosis group, and the endometriosis group treated flavonoids of Phaleria macrocarpa with dose of 3.75 mg/day; 7.5 mg/day; 11.2 mg/day; 15 mg/day. The level of IL-2, IL-17A, IL-33 were measured using the ELISA method. There was an increase in IL-2, IL-33, and IL17A levels in mice model of endometriosis. Flavonoid of Phaleria macrocarpa can reduce levels of proinflammatory cytokines such as IL-2, IL-33, and IL17A. Downloads Downloads Published Issue Section License Copyright (c) 2023 Gema Alya Salsabila, Ana Paramita Prastiwi, Leni Ria Ariana, Sutrisno Sutrisno, Nurdiana, Nanik Setijowati, I Wayan Agung Indrawan, Diadjeng Setya Wardani, Maharani This work is licensed under a Creative Commons Attribution 4.0 International License.

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endometriosis

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