Rediscovering peritoneal macrophages in a murine endometriosis model

Ming Yuan, Dong Li, Min An, Min Sung An, Qiuju Li, Lu Zhang, Guoyun Wang
Human Reproduction · 2016 · vol. 32(1) , pp. 94–102 · doi:10.1093/humrep/dew274 · PMID:27816922 · W2547351876
article OA: bronze CC0 ⤵ 52 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study found increased peritoneal macrophage subsets, LPMs and SPMs, in a murine endometriosis model, suggesting they may play stage-dependent roles in disease pathogenesis.

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Abstract

STUDY QUESTION: What are the features of peritoneal macrophage subgroups and T helper cells in the development of murine endometriosis? SUMMARY ANSWER: ) cells are increased. WHAT IS KNOWN ALREADY: Numerous studies investigating the etiology and pathogenesis of endometriosis have focused on the polarization states of peritoneal macrophages in endometriosis models and patients, but the results are inconclusive. Further studies indicate that peritoneal macrophages are composed of two distinct subsets: LPMs and SPMs, although their roles in endometriosis are unknown. STUDY DESIGN, SIZE, DURATION: This study involves a prospective and randomized experiment. Fifty C57BL/6 female mice were randomly allocated to five control and five experimental groups (n = 5/group) according to the presence or absence of transplantation. The transplant periods are 0.25, 3, 14, 28 and 42 days. PARTICIPANTS/MATERIALS, SETTING, METHODS: cells were estimated by FCM. MAIN RESULTS AND THE ROLE OF CHANCE: cells were all increased in mice with endometriosis. LARGE SCALE DATA: N/A. LIMITATIONS, REASONS FOR CAUTION: In this study, detection was only performed in a murine endometriosis model. Clinical data and more intervention experiments are required in understanding the roles of LPMs and SPMs in endometriosis. WIDER IMPLICATIONS OF THE FINDINGS: The dramatic changes of LPMs and SPMs in proportion and polarization profiles clarified the varying differentiation states of peritoneal macrophages. In addition, LPMs and SPMs may play different roles in the pathogenesis of endometriosis in different stages of endometriosis. Therefore, the new classification should be included in future relevant basic and clinical studies on endometriosis. STUDY FUNDING/COMPETING INTERESTS: This research was supported totally by grant 81270671 from the National Natural Science Foundation of China. The authors report no conflict of interest.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Macrophages, Peritoneal Peritoneum Animals Disease Models, Animal Endometriosis Endometriosis Endometrium Endometrium Female Macrophages, Peritoneal Macrophages, Peritoneal Mice Peritoneum Peritoneum Prospective Studies

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