Features of peritoneal dendritic cells in the development of endometriosis

Zheng Qiaomei, Qiaomei Zheng, Wu Ping, Ping Wu, Yan-Jing Zhao, Zhao Yanjing, Wang Jinhua, Jinhua Wang, Shaozhan Chen, Chen Shaozhan, Chen Lihong, Lihong Chen
Reproductive biology and endocrinology : RB&E · 2023 · vol. 21(1) , pp. 4 · doi:10.1186/s12958-023-01058-w · PMID:36639763 · PMC9837895 · W4316040209
article OA: gold CC0 ⤵ 7 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Peritoneal dendritic cell density increased in endometriosis patients and mouse models, with a higher proportion of immature cells, suggesting their role in lesion pathogenesis.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This paper studied peritoneal dendritic cells (DCs) in women with endometriosis and in a C57BL/6 mouse model, using FACS to quantify peritoneal DC density and the proportions of immature (iDC) versus mature (mDC) populations. In endometriosis patients sampled in the proliferative menstrual phase, peritoneal DC density was higher, with decreased mDCs (CD80highCD1alow) and increased iDCs (CD80lowCD1ahigh) compared with women without endometriosis; in mice, DC density rose immediately after endometrial tissue injection and peaked at 14 days, with maturity proportions showing time-dependent shifts that remained altered through 42 days. After LPS treatment, mDC proportions increased, and the paper reports lower endometriosis lesion volume and weight. The study’s caveats include its small patient sample size and the focus on a single DC maturation axis without additional mechanistic immune pathways beyond these phenotype and outcome measures. This paper is centrally about endometriosis — it examines how peritoneal DC density and impaired maturation relate to early lesion development in both patients and an endometriosis mouse model.

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Abstract

BACKGROUND: Emerging evidence of immunological dysfunction have been described in endometriosis. Dendritic cells (DCs), one of the main antigen-presenting cells, are specialized in the initiation and modulation of the adaptive immune response. Emerging studies demonstrated both endometrial and circulating differences in DCs populations in women with endometriosis. However, the role and mechanism of peritoneal DCs in endometriosis is still unclear. The present study was undertaken to explore the features of peritoneal DCs in the pathogenesis of endometriosis. This study is beneficial to further clarify the cause of endometriosis and provide a new insight into the medical treatment for endometriosis. METHODS: The study included 12 women with endometriosis and 11 women without endometriosis. The C57BL6 mouse model of endometriosis was established by intraperitoneal injection of endometrial segments. The peritoneal DCs of endometriosis patients and mouse models were analyzed by fluorescence associated cell sorting (FACS) examination. RESULTS: Increased cell density of peritoneal DCs were observed in endometriosis patients. Moreover, the proportion of mature DCs (mDCs, CD80highCD1alow cells) in the peritoneal DCs was lower whereas the proportion of immature DCs (iDCs, CD80lowCD1ahigh cells) was increased in endometriosis patients. Similarly, the cell density of peritoneal DCs in murine models increased immediately after the injection of endometrial tissues and reached the highest level at 14 days. In addition, the proportion of mDCs (CD11chighCD80high cells) in the peritoneal DCs decreased immediately after the injection of endometrial tissues and then increased with the time until 42 days, but still lower than the control group. In contrast, the proportion of iDCs (CD11chighCD80low cells) in the peritoneal DCs showed the opposite dynamic changes. However, after treated with LPS, the mDCs proportion was significantly increased, leading to lower volume and weight of the endometriosis lesions. CONCLUSIONS: Increased level of peritoneal DCs facilitated the pathogenesis of endometriosis lesions, especially in the early stage of the disease. Furthermore, peritoneal DCs maturation played an important role in the development of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Animals Animals Animals Animals Animals Animals Animals Animals Animals Cell Differentiation

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