Endometriosis: An Inflammatory Disease That Requires New Therapeutic Options
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Endometriosis, characterized by ectopic endometrial tissue in 10% of reproductive-aged women, is fundamentally an inflammatory condition necessitating novel therapeutic strategies.
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Abstract
Endometriosis, defined as the presence of endometrium-like tissue outside the uterus, is estimated to affect 10% of women of reproductive age [...].
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J.D.: conceptualization, original draft preparation. L.C.: review and editing. All authors have read and agreed to the published version of the manuscript.
Funding
This study was supported by grants from the Fonds National de la Recherche Scientifique de Belgique (F.R.S.-FNRS/FRIA FC29657 awarded to Luciana Cacciottola), Fonds Spéciaux de Recherche, Fondation St. Luc and the Foundation Against Cancer, and donations from the Ferrero family.
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The authors have no conflict of interest.
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References (12)
- Can Endometriosis-Related Oxidative Stress Pave the Way for New Treatment Targets? via openalex
- Ectopic Endometrium: The Pathologist’s Perspective via openalex
- Genetics and Inflammation in Endometriosis: Improving Knowledge for Development of New Pharmacological Strategies via openalex
- Intricate Connections between the Microbiota and Endometriosis via openalex
- Iron overload in the peritoneal cavity of women with pelvic endometriosis via openalex
- Iron storage is significantly increased in peritoneal macrophages of endometriosis patients and correlates with iron overload in peritoneal fluid via openalex
- N-Acyl Dopamines Induce Apoptosis in Endometrial Stromal Cells from Patients with Endometriosis via openalex
- New Therapeutics in Endometriosis: A Review of Hormonal, Non-Hormonal, and Non-Coding RNA Treatments via openalex
- Pathogenesis of Endometriosis: New Insights into Prospective Therapies via openalex
- Peritoneal endometriosis, ovarian endometriosis, and adenomyotic nodules of the rectovaginal septum are three different entities via openalex
- W3161227226 via openalex
- W3207063998 via openalex
Cited by (26)
- Electrospun Cellulose Acetate Nanofibers for Healthcare Products: Towards Sensing Pads for Endometriosis 2026
- RND3 Inhibits Endometriosis Progression by Regulating Autophagy and Oxidative Stress Through PLEKHG5 2025
- Nanomicelle curcumin improves oxidative stress, inflammatory markers, and assisted reproductive techniques outcomes in endometriosis cases: a randomized clinical trial 2025
- Phaleria Macrocarpa Extract Reduced Endometriosis Lesions by Regulating Inflammatory Protein and Inhibiting Ki67 and Vegf-A Protein 2025
- Targeting inflammation in endometriosis: emerging therapeutic options 2025
- Dual targeting of CXCR4 and EZH2 in endometriosis 2025
- Risk of neurodevelopmental disorders in the offspring of mothers with a history of endometriosis in Taiwanese women 2025
- Impact of endometrioma on iron levels and oxidative stress in the follicular fluid in women with endometriosis: a cross-sectional study 2025
- Molecular Regulator Driving Endometriosis Towards Endometrial Cancer: A Multi-Scale Computational Investigation to Repurpose Anti-Cancer drugs 2024
- Endometriosis: Pathogenesis, diagnosis, treatment and the role of gut microbiota 2024
- Shared biological features between ovarian cancer and endometriosis based on co-expression networks analysis 2024
- Dimethyl Fumarate Ameliorates the Endometriosis Through Anti‐Inflammatory and Anti‐Proliferation Mechanisms In Vitro and In Vivo 2024
- The clinical effect of dienogest on urinary and sexual symptoms in endometriosis patients 2024
- Linzagolix therapy versus a placebo in patients with endometriosis-associated pain: a prospective, randomized, double-blind, Phase 3 study (EDELWEISS 3) 2024
- Endometriosis: from iron and macrophages to exosomes. Is the sky clearing? 2024
- Pregnancy with endometriosis: Assessment of national-level trends, characteristics, and maternal morbidity at delivery 2024
- Prenatal Origins of Endometriosis Pathology and Pain: Reviewing the Evidence of a Role for Low Testosterone 2023
- Investigation of the Changes in Concentrations of Vitamin D-Binding Protein and Lactoferin in Plasma and Peritoneal Fluid of Patients with Endometriosis 2023
- TRATAMENTO CLÍNICO DA ENDOMETRIOSE PROFUNDA: UM PANORAMA ATUAL BASEADO EM EVIDÊNCIAS 2023
- Features of peritoneal dendritic cells in the development of endometriosis 2023
- Differential Protein Expression of mild to severe forms of Endometriosis in South Indian Ethnic patients 2023
- Isolation of myeloid-derived suppressor cells (MDSC) from endometriotic mice model and their immunomodulatory functions 2023
- (no title) 2023
- Association between polymorphisms of cytokine genes and endometriosis: A comprehensive systematic review and meta-analysis 2023
- Tanshinone ⅡA participates in the treatment of endometriosis by regulating adhesion, invasion, angiogenesis and inhibition of PI3K/Akt/mTOR signaling pathway 2023
- High intensity interval training is superior to moderate intensity continuous training in enhancing the anti-inflammatory and apoptotic effect of pentoxifylline in the rat model of endometriosis 2023
Source provenance
- europepmc
- last seen: 2026-07-31T06:09:14.520117+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-05-13T22:23:57.700195+00:00
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