Risk of neurodevelopmental disorders in the offspring of mothers with a history of endometriosis in Taiwanese women

Pei-Yin Yang, Ching-Ming Wang, C Wang, Pei-Lun Liao, Pei‐Lun Liao, Jing-Yang Huang, Jing‐Yang Huang, Keng‐Wei Liang, Keng-Wei Liang, Yu-Hsuan Lin, Yu‐Hsuan Lin, Shun-Fa Yang, Po-Hui Wang
Brain, behavior, & immunity - health · 2025 · vol. 47 , pp. 101038 · doi:10.1016/j.bbih.2025.101038 · PMID:40620707 · W4411476603
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study found that maternal endometriosis was associated with an increased risk of developmental delay and cerebral palsy in offspring, but not intellectual disabilities or other neurodevelopmental/psychiatric disorders.

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Abstract

Several neurodevelopmental disorders have been linked to early life immune activation and inflammation, including developmental delay, cerebral palsy, intellectual disabilities, and other neurodevelopmental and psychiatric disorders. Certain inflammatory cytokines, such as interleukin-1β, interleukin-6, and tumor necrosis factor-α, secreted by endometriosis cells cause chronic pelvic inflammation and pain. The aim of this study was to evaluate whether maternal endometriosis increased the risk of neurodevelopmental disorders in offspring in Taiwanese women . The study included eligible mother–offspring pairs with maternal endometriosis (the case cohort) and mother–offspring pairs without maternal endometriosis (the comparison cohort) matched for maternal age at delivery, infant sex, and delivery date, both with offspring born during 2009 to 2016 and followed till 2019, from the Taiwan Maternal and Child Health Database. The incidence rates and crude hazard ratios (HRs) of development delay and cerebral palsy in the offspring delivered by mothers with endometriosis were higher than those in the offspring delivered by mothers without endometriosis (developmental delay: incidence 1.51 vs. 1.30 per 1000 person-months, crude HR = 1.16; cerebral palsy: incidence 0.04 vs. 0.03 per 1000 person-months, HR = 1.38). In model 1, the adjusted HRs of development delay and cerebral palsy in the offspring of mothers with endometriosis were 1.16 (95% confidence interval [CI] = 1.11–1.22, P < 0.0001) and 1.39 (95% CI = 1.04–1.85, P = 0.0256). In model 2, these were 1.11 (95% CI =1.06–1.17) and 1.01 (95% CI = 0.76–1.36), respectively. However, the HRs of intellectual disabilities and other neurodevelopmental and psychiatric disorders were not significantly different between the offspring of mothers with and without endometriosis. In conclusion, maternal endometriosis may increase the risks of cerebral palsy and specifically developmental delay in offspring. • Hightlights • Offspring of mothers with endometriosis have higher risk of developmental delay • Offspring of mothers with endometriosis have higher risk of cerebral palsy • Offspring of mothers with endometriosis have no risk of intellectual disabilities • Case offspring have no risk of other neurodevelopmental and psychiatric disorders • Offspring have highest risk of development delay between 12 to 48 months after born

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endometriosis

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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