Dimethyl Fumarate Ameliorates the Endometriosis Through Anti‐Inflammatory and Anti‐Proliferation Mechanisms In Vitro and In Vivo

Advanced Hub Main Navigation Menu Dimethyl Fumarate Ameliorates the Endometriosis Through Anti-Inflammatory and Anti-Proliferation Mechanisms In Vitro and In Vivo Miji Kim Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, 02841 Republic of Korea Search for more papers by this authorWonhyoung Park Department of Animal Science, Chungbuk National University, Cheongju, 28644 Republic of Korea Search for more papers by this authorHee Seung Kim Department of Obstetrics and Gynecology, Seoul National University Hospital, Seoul, 03080 Republic of Korea Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, 03080 Republic of Korea Search for more papers by this authorSoo Jin Park Department of Obstetrics and Gynecology, Seoul National University Hospital, Seoul, 03080 Republic of Korea Search for more papers by this authorWhasun Lim Department of Biological Sciences, College of Science, Sungkyunkwan University, Suwon, 16419 Republic of Korea Search for more papers by this authorCorresponding Author Gwonhwa Song Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, 02841 Republic of Korea E-mail: [email protected]; [email protected] Search for more papers by this authorCorresponding Author Sunwoo Park Department of GreenBio Science, Gyeongsang National University, Jinju, 52725 Republic of Korea E-mail: [email protected]; [email protected] Search for more papers by this authorMiji Kim Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, 02841 Republic of Korea Search for more papers by this authorWonhyoung Park Department of Animal Science, Chungbuk National University, Cheongju, 28644 Republic of Korea Search for more papers by this authorHee Seung Kim Department of Obstetrics and Gynecology, Seoul National University Hospital, Seoul, 03080 Republic of Korea Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, 03080 Republic of Korea Search for more papers by this authorSoo Jin Park Department of Obstetrics and Gynecology, Seoul National University Hospital, Seoul, 03080 Republic of Korea Search for more papers by this authorWhasun Lim Department of Biological Sciences, College of Science, Sungkyunkwan University, Suwon, 16419 Republic of Korea Search for more papers by this authorCorresponding Author Gwonhwa Song Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, 02841 Republic of Korea E-mail: [email protected]; [email protected] Search for more papers by this authorCorresponding Author Sunwoo Park Department of GreenBio Science, Gyeongsang National University, Jinju, 52725 Republic of Korea E-mail: [email protected]; [email protected] Search for more papers by this authorAbstract Dimethyl fumarate is a widely known therapeutic agent with anti-inflammatory properties for psoriasis and multiple sclerosis. Despite the current attempts to use dimethyl fumarate for treating various inflammatory diseases, its effects on endometriosis have not been previously reported. Endometriosis is a genital disease that causes various health problems in women, and treatment methods targeting the inflammatory environment are being attempted. Therefore, it is hypothesized that dimethyl fumarate has therapeutic effects on endometriosis through its anti-inflammatory effects. Dimethyl fumarate exerted remarkable effects on cellular mechanisms, including reactive oxygen species production, activation of mitogen‑activated protein kinase signals, loss of mitochondrial function, and disruption of calcium ion homeostasis in the immortalized human ovarian endometrial stromal cells. In an endometriosis mouse model, dimethyl fumarate downregulated cell cycle-related genes and induced inhibitory effects on endometriosis lesion growth. In particular, the immune cell population and expression of inflammatory cytokines such as IL-1β, IL-6, and IL-10 are regulated by dimethyl fumarate. These results support its potential as a therapeutic agent to control the excessive inflammatory environment in patients with endometriosis. This study identifies for the first time that dimethyl fumarate, which is already in clinical use, can be used to treat endometriosis. Conflict of Interest The authors declare no conflict of interest. Data Availability Statement Data sharing is not applicable to this article as no new data were created or analyzed in this study. References - 1L. C. Giudice, L. C. Kao, Endometriosis. Lancet 2004, 364, 1789. - 2E. S. Surrey, A. M. Soliman, B. Johns, J. B. Vora, H. S. Taylor, S. K. Agarwal, Clinicoecon. Outcomes Res. 2020, 12, 473. - 3I. Selcuk, G. Bozdag, J. Turk. Ger. Gynecol. Assoc. 2013, 14, 98. - 4C. J. Lee, M. J. Kang, S. Y. Kim, I. H. Han, H. S. Bae, Mol. Cell. Toxicol. 2022, 18, 111. - 5S. H. 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