{"paper_id":"276d7d27-ddcf-424d-b3a5-71072dfc03ec","body_text":"Advanced Hub Main Navigation Menu\nDimethyl Fumarate Ameliorates the Endometriosis Through Anti-Inflammatory and Anti-Proliferation Mechanisms In Vitro and In Vivo\nMiji Kim\nDepartment of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, 02841 Republic of Korea\nSearch for more papers by this authorWonhyoung Park\nDepartment of Animal Science, Chungbuk National University, Cheongju, 28644 Republic of Korea\nSearch for more papers by this authorHee Seung Kim\nDepartment of Obstetrics and Gynecology, Seoul National University Hospital, Seoul, 03080 Republic of Korea\nDepartment of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, 03080 Republic of Korea\nSearch for more papers by this authorSoo Jin Park\nDepartment of Obstetrics and Gynecology, Seoul National University Hospital, Seoul, 03080 Republic of Korea\nSearch for more papers by this authorWhasun Lim\nDepartment of Biological Sciences, College of Science, Sungkyunkwan University, Suwon, 16419 Republic of Korea\nSearch for more papers by this authorCorresponding Author\nGwonhwa Song\nDepartment of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, 02841 Republic of Korea\nE-mail: [email protected]; [email protected]\nSearch for more papers by this authorCorresponding Author\nSunwoo Park\nDepartment of GreenBio Science, Gyeongsang National University, Jinju, 52725 Republic of Korea\nE-mail: [email protected]; [email protected]\nSearch for more papers by this authorMiji Kim\nDepartment of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, 02841 Republic of Korea\nSearch for more papers by this authorWonhyoung Park\nDepartment of Animal Science, Chungbuk National University, Cheongju, 28644 Republic of Korea\nSearch for more papers by this authorHee Seung Kim\nDepartment of Obstetrics and Gynecology, Seoul National University Hospital, Seoul, 03080 Republic of Korea\nDepartment of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, 03080 Republic of Korea\nSearch for more papers by this authorSoo Jin Park\nDepartment of Obstetrics and Gynecology, Seoul National University Hospital, Seoul, 03080 Republic of Korea\nSearch for more papers by this authorWhasun Lim\nDepartment of Biological Sciences, College of Science, Sungkyunkwan University, Suwon, 16419 Republic of Korea\nSearch for more papers by this authorCorresponding Author\nGwonhwa Song\nDepartment of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, 02841 Republic of Korea\nE-mail: [email protected]; [email protected]\nSearch for more papers by this authorCorresponding Author\nSunwoo Park\nDepartment of GreenBio Science, Gyeongsang National University, Jinju, 52725 Republic of Korea\nE-mail: [email protected]; [email protected]\nSearch for more papers by this authorAbstract\nDimethyl fumarate is a widely known therapeutic agent with anti-inflammatory properties for psoriasis and multiple sclerosis. Despite the current attempts to use dimethyl fumarate for treating various inflammatory diseases, its effects on endometriosis have not been previously reported. Endometriosis is a genital disease that causes various health problems in women, and treatment methods targeting the inflammatory environment are being attempted. Therefore, it is hypothesized that dimethyl fumarate has therapeutic effects on endometriosis through its anti-inflammatory effects. Dimethyl fumarate exerted remarkable effects on cellular mechanisms, including reactive oxygen species production, activation of mitogen‑activated protein kinase signals, loss of mitochondrial function, and disruption of calcium ion homeostasis in the immortalized human ovarian endometrial stromal cells. In an endometriosis mouse model, dimethyl fumarate downregulated cell cycle-related genes and induced inhibitory effects on endometriosis lesion growth. In particular, the immune cell population and expression of inflammatory cytokines such as IL-1β, IL-6, and IL-10 are regulated by dimethyl fumarate. These results support its potential as a therapeutic agent to control the excessive inflammatory environment in patients with endometriosis. This study identifies for the first time that dimethyl fumarate, which is already in clinical use, can be used to treat endometriosis.\nConflict of Interest\nThe authors declare no conflict of interest.\nData Availability Statement\nData sharing is not applicable to this article as no new data were created or analyzed in this study.\nReferences\n- 1L. C. Giudice, L. C. Kao, Endometriosis. Lancet 2004, 364, 1789.\n- 2E. S. Surrey, A. M. Soliman, B. Johns, J. B. Vora, H. S. Taylor, S. K. Agarwal, Clinicoecon. Outcomes Res. 2020, 12, 473.\n- 3I. Selcuk, G. Bozdag, J. Turk. Ger. Gynecol. Assoc. 2013, 14, 98.\n- 4C. J. Lee, M. J. Kang, S. Y. Kim, I. H. Han, H. S. Bae, Mol. Cell. 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Exp. 2012, 59, e3396.\n- 65S. Park, W. Lim, F. W. Bazer, K.-Y. Whang, G. Song, J. Nutr. Biochem. 2019, 63, 87.\nArticle Metrics\nTotal unique accesses to an article’s full text in HTML or PDF/ePDF format.More metric information\nScite metrics\nExplore this article's citation statements on scite.ai\nShare QR Code\nGenerating QR code\nQR code copied to clipboard!\nSomething went wrong while generating your QR code. Please try again in a moment. If the issue persists, refresh the page or contact support.\nExport citation\nUnable to load citation data. Please try again in a moment.\nHow to cite\nElkins, L. J., & Spiegelman, M. (2021). pyUserCalc: A revised Jupyter notebook calculator for uranium-series disequilibria in basalts. Earth and Space Science, 8, e2020EA001619. https://doi.org/10.1029/2020EA001619\nDownload Citation\nIf you have the appropriate software installed, you can download article citation data to the citation manager of your choice. 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