The role of innate and adaptive immunity in endometriosis

Khaleque N Khan; Khaleque Newaz Khan; Sun-Wei Guo; Sun‐Wei Guo; Kanae Ogawa; Akira Fujishita; Taisuke Mori

doi:10.1016/j.jri.2024.104242

The role of innate and adaptive immunity in endometriosis

Khaleque N Khan, Khaleque Newaz Khan, Sun-Wei Guo, Sun‐Wei Guo, Kanae Ogawa, Akira Fujishita, Taisuke Mori

Journal of reproductive immunology · 2024 · vol. 163 , pp. 104242 · doi:10.1016/j.jri.2024.104242 · PMID:38503076 · W4392768778

article OA: closed CC0 ⤵ 6 in-corpus citations

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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This paper investigates the involvement of both innate and adaptive immune responses in the development and progression of endometriosis.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

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Condition tags

endometriosis

MeSH descriptors

Adaptive Immunity Adaptive Immunity Adaptive Immunity Adaptive Immunity Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Immunity, Innate Immunity, Innate Immunity, Innate Immunity, Innate Animals Animals Animals Animals Female Female

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (100)

17β-Estradiol and Lipopolysaccharide Additively Promote Pelvic Inflammation and Growth of Endometriosis via openalex
1-Methyl-tryptophan attenuates regulatory T cells differentiation due to the inhibition of estrogen-IDO1-MRC2 axis in endometriosis via openalex
Association between FOXP3+ regulatory T-cells and occurrence of peritoneal lesions in women with ovarian endometrioma and dermoid cysts via openalex
Bacterial contamination hypothesis: a new concept in endometriosis via openalex
Coelomic Metaplasia Theory of Endometriosis: Evidence from in vivo Studies and an in vitro Experimental Model via openalex
Decrease in interferon gamma production and impairment of T-lymphocyte proliferation in peritoneal fluid of women with endometriosis via openalex
Differential Levels of Regulatory T Cells and T-Helper-17 Cells in Women With Early and Advanced Endometriosis via openalex
Endometrial causes of recurrent pregnancy losses: endometriosis, adenomyosis, and chronic endometritis via openalex
Endometriosis: Interaction of Immune and Endocrine Systems via openalex
Endometriosis with infertility: A comprehensive review on the role of immune deregulation and immunomodulation therapy via openalex
Escherichia coli contamination of menstrual blood and effect of bacterial endotoxin on endometriosis via openalex
Exacerbation of Endometriosis Due To Regulatory T-Cell Dysfunction via openalex
Hepatocyte growth factor may be involved in cellular changes to the peritoneal mesothelium adjacent to pelvic endometriosis via openalex
IL-17A Contributes to the Pathogenesis of Endometriosis by Triggering Proinflammatory Cytokines and Angiogenic Growth Factors via openalex
Immunological Aspects of Endometriosis: An Update via openalex
Immunological aspects of endometriosis: a review. via openalex
Immunopathogenesis of endometriosis – a novel look at an old problem via openalex
Implications of immune dysfunction on endometriosis associated infertility via openalex
Increased percentage of Th17 cells in peritoneal fluid is associated with severity of endometriosis via openalex
Interleukin-33 Derived from Endometriotic Lesions Promotes Fibrogenesis through Inducing the Production of Profibrotic Cytokines by Regulatory T Cells via openalex
Interleukin (IL)-17A Stimulates IL-8 Secretion, Cyclooxygensase-2 Expression, and Cell Proliferation of Endometriotic Stromal Cells via openalex
Intra-uterine microbial colonization and occurrence of endometritis in women with endometriosis† via openalex
Lipopolysaccharide promotes the development of murine endometriosis‐like lesions via the nuclear factor‐kappa B pathway via openalex
Lymphocytes in Endometriosis via openalex
Molecular detection of intrauterine microbial colonization in women with endometriosis via openalex
Origin of endometriosis from the mesenchyme of the celomic walls via openalex
Peritoneal endometriosis due to the menstrual dissemination of endometrial tissue into the peritoneal cavity via openalex
Peritoneal fluid concentrations of interleukin‐17 correlate with the severity of endometriosis and infertility of this disorder via openalex
Platelets and Regulatory T Cells May Induce a Type 2 Immunity That Is Conducive to the Progression and Fibrogenesis of Endometriosis via openalex
Recruitment of CCR6-Expressing Th17 Cells by CCL 20 Secreted from IL-1β-, TNF-α-, and IL-17A-Stimulated Endometriotic Stromal Cells via openalex
Regulatory T cells and other leukocytes in the pathogenesis of endometriosis via openalex
Retrograde menstruation in healthy women and in patients with endometriosis. via openalex
Role of TGF- s in normal human endometrium and endometriosis via openalex
The involvement of T lymphocytes in the pathogenesis of endometriotic tissues overgrowth in women with endometriosis via openalex
The Role of Peritoneal Immunity in Peritoneal Endometriosis and Related Infertility via openalex
The Role of Peritoneal Macrophages in Endometriosis via openalex
Toll‐like receptor system and endometriosis via openalex
T regulatory lymphocytes in patients with endometriosis via openalex
W2131621879 via openalex
W2133031521 via openalex
W2133449490 via openalex
W2137590150 via openalex
W2138277367 via openalex
W2139802799 via openalex
W2141649011 via openalex
W2149886990 via openalex
W2149915530 via openalex
W2152014155 via openalex
W2152508754 via openalex
W2155227851 via openalex
W2155779547 via openalex
W2156964052 via openalex
W2157339124 via openalex
W2158550801 via openalex
W2162097247 via openalex
W2171260427 via openalex
W2256155471 via openalex
W2418371708 via openalex
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W2559895200 via openalex
W2797582001 via openalex
W3182783528 via openalex
W4236842068 via openalex
W4313462360 via openalex
W6603821203 via openalex
W6631208994 via openalex
W6635970867 via openalex
W6660202593 via openalex
W6675755363 via openalex
W6717035822 via openalex
W6848452090 via openalex
W141728048 via openalex
W1483162601 via openalex
W1484335948 via openalex
W1574697659 via openalex
W1968143482 via openalex
W1977609213 via openalex
W1980273234 via openalex
W2004465286 via openalex
W2004755026 via openalex
W2007631222 via openalex
W2010737442 via openalex
W2019077533 via openalex
W2020158930 via openalex
W2036334866 via openalex
W2039467806 via openalex
W2048254575 via openalex
W2048842878 via openalex
W2057809738 via openalex
W2060220862 via openalex
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W2065911024 via openalex
W2072853625 via openalex
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W2085918020 via openalex
W2095833996 via openalex
W2097425822 via openalex
W2100592302 via openalex
W2104159258 via openalex
W2105652521 via openalex

Cited by (6)

Source provenance

europepmc: last seen: 2026-06-11T06:19:48.454388+00:00
openalex: last seen: 2026-06-10T17:14:06.276822+00:00
pubmed: last seen: 2026-06-04T00:32:58.938080+00:00
unpaywall: last seen: 2026-06-02T02:00:03.124865+00:00

License: CC0 · commercial use OK

[1] 17β-Estradiol and Lipopolysaccharide Additively Promote Pelvic Inflammation and Growth of Endometriosis via openalex

[2] 1-Methyl-tryptophan attenuates regulatory T cells differentiation due to the inhibition of estrogen-IDO1-MRC2 axis in endometriosis via openalex

[3] Association between FOXP3+ regulatory T-cells and occurrence of peritoneal lesions in women with ovarian endometrioma and dermoid cysts via openalex

[4] Bacterial contamination hypothesis: a new concept in endometriosis via openalex

[5] Coelomic Metaplasia Theory of Endometriosis: Evidence from in vivo Studies and an in vitro Experimental Model via openalex

[6] Decrease in interferon gamma production and impairment of T-lymphocyte proliferation in peritoneal fluid of women with endometriosis via openalex

[7] Differential Levels of Regulatory T Cells and T-Helper-17 Cells in Women With Early and Advanced Endometriosis via openalex

[8] Endometrial causes of recurrent pregnancy losses: endometriosis, adenomyosis, and chronic endometritis via openalex

[9] Endometriosis: Interaction of Immune and Endocrine Systems via openalex

[10] Endometriosis with infertility: A comprehensive review on the role of immune deregulation and immunomodulation therapy via openalex

[11] Escherichia coli contamination of menstrual blood and effect of bacterial endotoxin on endometriosis via openalex

[12] Exacerbation of Endometriosis Due To Regulatory T-Cell Dysfunction via openalex

[13] Hepatocyte growth factor may be involved in cellular changes to the peritoneal mesothelium adjacent to pelvic endometriosis via openalex

[14] IL-17A Contributes to the Pathogenesis of Endometriosis by Triggering Proinflammatory Cytokines and Angiogenic Growth Factors via openalex

[15] Immunological Aspects of Endometriosis: An Update via openalex

[16] Immunological aspects of endometriosis: a review. via openalex

[17] Immunopathogenesis of endometriosis – a novel look at an old problem via openalex

[18] Implications of immune dysfunction on endometriosis associated infertility via openalex

[19] Increased percentage of Th17 cells in peritoneal fluid is associated with severity of endometriosis via openalex

[20] Interleukin-33 Derived from Endometriotic Lesions Promotes Fibrogenesis through Inducing the Production of Profibrotic Cytokines by Regulatory T Cells via openalex

[21] Interleukin (IL)-17A Stimulates IL-8 Secretion, Cyclooxygensase-2 Expression, and Cell Proliferation of Endometriotic Stromal Cells via openalex

[22] Intra-uterine microbial colonization and occurrence of endometritis in women with endometriosis† via openalex

[23] Lipopolysaccharide promotes the development of murine endometriosis‐like lesions via the nuclear factor‐kappa B pathway via openalex

[24] Lymphocytes in Endometriosis via openalex

[25] Molecular detection of intrauterine microbial colonization in women with endometriosis via openalex

[26] Origin of endometriosis from the mesenchyme of the celomic walls via openalex

[27] Peritoneal endometriosis due to the menstrual dissemination of endometrial tissue into the peritoneal cavity via openalex

[28] Peritoneal fluid concentrations of interleukin‐17 correlate with the severity of endometriosis and infertility of this disorder via openalex

[29] Platelets and Regulatory T Cells May Induce a Type 2 Immunity That Is Conducive to the Progression and Fibrogenesis of Endometriosis via openalex

[30] Recruitment of CCR6-Expressing Th17 Cells by CCL 20 Secreted from IL-1β-, TNF-α-, and IL-17A-Stimulated Endometriotic Stromal Cells via openalex

[31] Regulatory T cells and other leukocytes in the pathogenesis of endometriosis via openalex

[32] Retrograde menstruation in healthy women and in patients with endometriosis. via openalex

[33] Role of TGF- s in normal human endometrium and endometriosis via openalex

[34] The involvement of T lymphocytes in the pathogenesis of endometriotic tissues overgrowth in women with endometriosis via openalex

[35] The Role of Peritoneal Immunity in Peritoneal Endometriosis and Related Infertility via openalex

[36] The Role of Peritoneal Macrophages in Endometriosis via openalex

[37] Toll‐like receptor system and endometriosis via openalex

[38] T regulatory lymphocytes in patients with endometriosis via openalex

[39] W2131621879 via openalex

[40] W2133031521 via openalex

[41] W2133449490 via openalex

[42] W2137590150 via openalex

[43] W2138277367 via openalex

[44] W2139802799 via openalex

[45] W2141649011 via openalex

[46] W2149886990 via openalex

[47] W2149915530 via openalex

[48] W2152014155 via openalex

[49] W2152508754 via openalex

[50] W2155227851 via openalex

[51] W2155779547 via openalex

[52] W2156964052 via openalex

[53] W2157339124 via openalex

[54] W2158550801 via openalex

[55] W2162097247 via openalex

[56] W2171260427 via openalex

[57] W2256155471 via openalex

[58] W2418371708 via openalex

[59] W2505159449 via openalex

[60] W2559895200 via openalex

[61] W2797582001 via openalex

[62] W3182783528 via openalex

[63] W4236842068 via openalex

[64] W4313462360 via openalex

[65] W6603821203 via openalex

[66] W6631208994 via openalex

[67] W6635970867 via openalex

[68] W6660202593 via openalex

[69] W6675755363 via openalex

[70] W6717035822 via openalex

[71] W6848452090 via openalex

[72] W141728048 via openalex

[73] W1483162601 via openalex

[74] W1484335948 via openalex

[75] W1574697659 via openalex

[76] W1968143482 via openalex

[77] W1977609213 via openalex

[78] W1980273234 via openalex

[79] W2004465286 via openalex

[80] W2004755026 via openalex

[81] W2007631222 via openalex

[82] W2010737442 via openalex

[83] W2019077533 via openalex

[84] W2020158930 via openalex

[85] W2036334866 via openalex

[86] W2039467806 via openalex

[87] W2048254575 via openalex

[88] W2048842878 via openalex

[89] W2057809738 via openalex

[90] W2060220862 via openalex

[91] W2060523664 via openalex

[92] W2065911024 via openalex

[93] W2072853625 via openalex

[94] W2077492907 via openalex

[95] W2085918020 via openalex

[96] W2095833996 via openalex

[97] W2097425822 via openalex

[98] W2100592302 via openalex

[99] W2104159258 via openalex

[100] W2105652521 via openalex