Interleukin (IL)-17A Stimulates IL-8 Secretion, Cyclooxygensase-2 Expression, and Cell Proliferation of Endometriotic Stromal Cells

Tetsuya Hirata, Yutaka Osuga, Kahori Hamasaki, Osamu Yoshino, Mika Ito, Akiko Hasegawa, Yuri Takemura, Yasushi Hirota, Emi Nose, Chieko Morimoto, Miyuki Harada, Kaori Koga, Toshiki Tajima, T. Tajima, Shigeru Saito, Tetsu Yano, Yuji Taketani
Endocrinology · 2007 · vol. 149(3) , pp. 1260–1267 · doi:10.1210/en.2007-0749 · PMID:18079209 · W2081453686
article OA: bronze CC0 ⤵ 85 in-corpus citations
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This study found that IL-17A enhances IL-8 secretion, COX-2 expression, and proliferation of endometriotic stromal cells, potentially contributing to endometriosis development.

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Abstract

IL-17A is secreted from Th17 cells, a discovery leading to revision of the mechanism underlying the role of Th1/Th2 in the immune response. Strong evidence suggests that immune responses associated with inflammation are involved in the pathogenesis of endometriosis. In the present study, we first demonstrated that the presence of Th17 cells in peritoneal fluid of endometriotic women by flow cytometric analysis and IL-17A-positive cells in endometriotic tissues by immunohistochemistry. To investigate the role of IL-17A in the development of endometriosis, we then studied the effect of IL-17A on IL-8 production, cyclooxygensase-2 expression, and cell proliferation of cultured endometriotic stromal cells (ESCs). IL-17A enhanced IL-8 secretion from ESCs in a dose-dependent manner. The IL-17A-induced secretion of IL-8 from ESCs was suppressed by anti-IL-17 receptor A antibodies or inhibitors of p38 MAPK, p42/44 MAPK, and stress-activated protein kinase/c-Jun N-terminal kinase. Addition of TNFalpha synergistically increased IL-17A-induced IL-8 secretion from ESCs. IL-17A also enhanced the expression of cyclooxygensase-2 mRNA and proliferation of ESCs. IL-17A may play a role in the development of endometriosis by stimulating inflammatory responses and proliferation of ESCs.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Cell Proliferation Cyclooxygenase 2 Endometrium Interleukin-17 Interleukin-8 Stromal Cells Antibodies, Anti-Idiotypic Antibodies, Anti-Idiotypic Cells, Cultured Cyclooxygenase 2 Endometriosis Endometriosis Endometriosis Endometriosis Endometrium Endometrium Female Humans Interleukin-17 Interleukin-8

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