Potential link between the nerve injury-induced protein (Ninjurin) and the pathogenesis of endometriosis

Sijian Hu; Weina Guo; Yi Shen

doi:10.1016/j.intimp.2022.109452

Potential link between the nerve injury-induced protein (Ninjurin) and the pathogenesis of endometriosis

Sijian Hu, Weina Guo, Yi Shen

International immunopharmacology · 2022 · vol. 114 , pp. 109452 · doi:10.1016/j.intimp.2022.109452 · PMID:36446236 · W4310015897

review OA: closed CC0 ⤵ 2 in-corpus citations

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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study investigated the potential role of the nerve injury-induced protein Ninjurin in the development and progression of endometriosis.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

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References (100)

Abnormal peritoneal regulation of chemokine activation—The role of <scp>IL</scp>‐8 in pathogenesis of endometriosis via openalex
Angiogenic Factors in Endometriosis via openalex
An Update on the Multifaceted Role of NF-kappaB in Endometriosis via openalex
A Prospective Study of Inflammatory Markers and Risk of Endometriosis via openalex
Autonomic nervous system and inflammation interaction in endometriosis-associated pain via openalex
Bone Marrow Stem Cell Chemotactic Activity Is Induced by Elevated CXCl12 in Endometriosis via openalex
Bradykinin system is involved in endometriosis‐related pain through endothelin‐1 production via openalex
Can symptomatology help in the diagnosis of endometriosis? Findings from a national case–control study—Part 1 via openalex
Chronic stress accelerates the development of endometriosis in mouse through adrenergic receptor β<sub>2</sub> via openalex
Circulating Neutrophil Extracellular Traps Are Elevated in Patients With Deep Infiltrating Endometriosis via openalex
Combined inhibition of vascular endothelial growth factor (VEGF), fibroblast growth factor and platelet-derived growth factor, but not inhibition of VEGF alone, effectively suppresses angiogenesis and vessel maturation in endometriotic lesions via openalex
Correlation between symptoms of pain and peritoneal fluid inflammatory cytokine concentrations in endometriosis via openalex
Cytokine profiles in serum and peritoneal fluid from infertile women with and without endometriosis via openalex
Dendritic cell populations in the eutopic and ectopic endometrium of women with endometriosis via openalex
Ectopic endometriotic stromal cells‐derived lactate induces <scp>M2</scp> macrophage polarization via Mettl3/Trib1/<scp>ERK</scp>/<scp>STAT3</scp> signalling pathway in endometriosis via openalex
Effect of antiangiogenic treatment on peritoneal endometriosis-associated nerve fibers via openalex
Elevated glycodelin-A concentrations in serum and peritoneal fluid of women with ovarian endometriosis via openalex
Endometriosis via openalex
Endometriosis: a consequence of varying injuries to pelvic autonomic nerves via openalex
Endometriosis alters brain electrophysiology, gene expression and increases pain sensitization, anxiety, and depression in female mice† via openalex
Endometriosis and Cancer: Exploring the Role of Macrophages via openalex
Endometriosis-associated nerve fibers, peritoneal fluid cytokine concentrations, and pain in endometriotic lesions from different locations via openalex
Endometriosis-induced vaginal hyperalgesia in the rat: Role of the ectopic growths and their innervation via openalex
Endometriosis: pathogenesis and treatment via openalex
Endometriosis: the consequence of uterine denervation–reinnervation via openalex
Endometriosis: The Role of Neuroangiogenesis via openalex
Endometriosis: What is the Influence of Immune Cells? via openalex
EPIDEMIOLOGY OF ENDOMETRIOSIS via openalex
Estrogen Receptor (ER) Agonists Differentially Regulate Neuroangiogenesis in Peritoneal Endometriosis via the Repellent Factor SLIT3 via openalex
Evaluation of M1 and M2 macrophages in ovarian endometriomas from women affected by endometriosis at different stages of the disease via openalex
Evidence of neurotrophic events due to peritoneal endometriotic lesions via openalex
Expression of inflammatory cytokines in serum and peritoneal fluid from patients with different stages of endometriosis via openalex
Expression of microtubule associated protein 2 and synaptophysin in endometrium: high levels in deep infiltrating endometriosis lesions via openalex
Expression of Nerve Injury-Induced Protein1 (Ninj1) in Endometriosis via openalex
Fractalkine/CX3CR1 Contributes to Endometriosis-Induced Neuropathic Pain and Mechanical Hypersensitivity in Rats via openalex
G-Protein-Coupled Receptor CXCR7 Is Overexpressed in Human and Murine Endometriosis via openalex
Identification and Quantification of Dopamine Receptor 2 in Human Eutopic and Ectopic Endometrium: A Novel Molecular Target for Endometriosis Therapy1 via openalex
Immunological aspects of endometriosis: a review. via openalex
Immunology of endometriosis via openalex
Increased Leptin Levels in Serum and Peritoneal Fluid of Patients with Pelvic Endometriosis via openalex
Inflammation and nerve fiber interaction in endometriotic pain via openalex
Inflammatory Mediators and Pain in Endometriosis: A Systematic Review via openalex
Innervation of ectopic endometrium in a rat model of endometriosis via openalex
Interleukin-17A is present in neutrophils in endometrioma and stimulates the secretion of growth-regulated oncogene–α (Gro-α) from endometrioma stromal cells via openalex
Interleukin‐1β activated c‐FOS transcription factor binds preferentially to a specific allele of the matrix metalloproteinase‐13 promoter and increases susceptibility to endometriosis via openalex
Interleukin (IL)-17A Stimulates IL-8 Secretion, Cyclooxygensase-2 Expression, and Cell Proliferation of Endometriotic Stromal Cells via openalex
In vivo analysis of angiogenesis in endometriosis-like lesions by intravital fluorescence microscopy via openalex
KLFII is an Epigenetic Mediator of DRD2/Dopaminergic Signaling in Endometriosis via openalex
Localization of progesterone-associated endometrial protein mRNA by in-situ hybridization in human pregnancy decidua, endometriosis and borderline endometrioid adenoma via openalex
<p>Research on central sensitization of endometriosis-associated pain: a systematic review of the literature</p> via openalex
Macrophages and nerve fibres in peritoneal endometriosis via openalex
Macrophages display proinflammatory phenotypes in the eutopic endometrium of women with endometriosis with relevance to an infectious etiology of the disease via openalex
Mechanisms of pain in endometriosis via openalex
Nerve fibres in peritoneal endometriosis via openalex
Neuroimmunomodulatory Alterations in Non-Lesional Peritoneum Close to Peritoneal Endometriosis via openalex
Neuropeptides Substance P and Calcitonin Gene Related Peptide Accelerate the Development and Fibrogenesis of Endometriosis via openalex
New developments in the medical treatment of endometriosis via openalex
Pathogenesis of endometriosis: Interaction between Endocrine and inflammatory pathways via openalex
Pathogenesis of Endometriosis: The Origin of Pain and Subfertility via openalex
Pathophysiology of endometriosis-associated pain: A review of pelvic and central nervous system mechanisms via openalex
Peritoneal Fluid Cytokines Reveal New Insights of Endometriosis Subphenotypes via openalex
Peritoneal fluid leptin is associated with chronic pelvic pain but not infertility in endometriosis patients* via openalex
Platelets drive smooth muscle metaplasia and fibrogenesis in endometriosis through epithelial–mesenchymal transition and fibroblast-to-myofibroblast transdifferentiation via openalex
Polarized Macrophages As Potential Anti‐Endometrioid agent via openalex
Rich innervation of deep infiltrating endometriosis via openalex
Role of interleukin-1 receptor type II in the pathogenesis of endometriosis via openalex
Role of interleukin-32 in the pathogenesis of endometriosis: in vitro, human and transgenic mouse data via openalex
Role of the CXCL12–CXCR4 axis in the development of deep rectal endometriosis via openalex
Sensory nerve-derived neuropeptides accelerate the development and fibrogenesis of endometriosis via openalex
Serum and Ectopic Endometrium from Women with Endometriosis Modulate Macrophage M1/M2 Polarization via the Smad2/Smad3 Pathway via openalex
Social psychogenic stress promotes the development of endometriosis in mouse via openalex
Sphingosine I Phosphate (S1P) Increased IL-6 Expression and Cell Growth in Endometriotic Cells via openalex
The effect of growth factors on the proliferation of human endometrial stromal cells in culture via openalex
The Pains of Endometriosis via openalex
The Role of the Immune System in the Development of Endometriosis via openalex
Tumour necrosis factor α concentrations in the peritoneal fluid of infertile women with minimal or mild endometriosis are lower in patients with red lesions only than in patients without red lesions via openalex
W3009375185 via openalex
W3021094484 via openalex
W3092324413 via openalex
W3092539319 via openalex
W3112277875 via openalex
W3115667040 via openalex
W3118462917 via openalex
W3124409908 via openalex
W3134410474 via openalex
W3186834051 via openalex
W3213122472 via openalex
W3216001998 via openalex
W4200608079 via openalex
W4205113655 via openalex
W4207052379 via openalex
W4211081176 via openalex
W4223479460 via openalex
W4281261751 via openalex
W4283457825 via openalex
W4284898089 via openalex
W4297537365 via openalex
W4297990794 via openalex
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W6661697487 via openalex

Cited by (2)

Source provenance

europepmc: last seen: 2026-06-04T01:30:01.192114+00:00
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pubmed: last seen: 2026-06-04T00:34:19.035172+00:00

License: CC0 · commercial use OK

[1] Abnormal peritoneal regulation of chemokine activation—The role of <scp>IL</scp>‐8 in pathogenesis of endometriosis via openalex

[2] Angiogenic Factors in Endometriosis via openalex

[3] An Update on the Multifaceted Role of NF-kappaB in Endometriosis via openalex

[4] A Prospective Study of Inflammatory Markers and Risk of Endometriosis via openalex

[5] Autonomic nervous system and inflammation interaction in endometriosis-associated pain via openalex

[6] Bone Marrow Stem Cell Chemotactic Activity Is Induced by Elevated CXCl12 in Endometriosis via openalex

[7] Bradykinin system is involved in endometriosis‐related pain through endothelin‐1 production via openalex

[8] Can symptomatology help in the diagnosis of endometriosis? Findings from a national case–control study—Part 1 via openalex

[9] Chronic stress accelerates the development of endometriosis in mouse through adrenergic receptor β<sub>2</sub> via openalex

[10] Circulating Neutrophil Extracellular Traps Are Elevated in Patients With Deep Infiltrating Endometriosis via openalex

[11] Combined inhibition of vascular endothelial growth factor (VEGF), fibroblast growth factor and platelet-derived growth factor, but not inhibition of VEGF alone, effectively suppresses angiogenesis and vessel maturation in endometriotic lesions via openalex

[12] Correlation between symptoms of pain and peritoneal fluid inflammatory cytokine concentrations in endometriosis via openalex

[13] Cytokine profiles in serum and peritoneal fluid from infertile women with and without endometriosis via openalex

[14] Dendritic cell populations in the eutopic and ectopic endometrium of women with endometriosis via openalex

[15] Ectopic endometriotic stromal cells‐derived lactate induces <scp>M2</scp> macrophage polarization via Mettl3/Trib1/<scp>ERK</scp>/<scp>STAT3</scp> signalling pathway in endometriosis via openalex

[16] Effect of antiangiogenic treatment on peritoneal endometriosis-associated nerve fibers via openalex

[17] Elevated glycodelin-A concentrations in serum and peritoneal fluid of women with ovarian endometriosis via openalex

[18] Endometriosis via openalex

[19] Endometriosis: a consequence of varying injuries to pelvic autonomic nerves via openalex

[20] Endometriosis alters brain electrophysiology, gene expression and increases pain sensitization, anxiety, and depression in female mice† via openalex

[21] Endometriosis and Cancer: Exploring the Role of Macrophages via openalex

[22] Endometriosis-associated nerve fibers, peritoneal fluid cytokine concentrations, and pain in endometriotic lesions from different locations via openalex

[23] Endometriosis-induced vaginal hyperalgesia in the rat: Role of the ectopic growths and their innervation via openalex

[24] Endometriosis: pathogenesis and treatment via openalex

[25] Endometriosis: the consequence of uterine denervation–reinnervation via openalex

[26] Endometriosis: The Role of Neuroangiogenesis via openalex

[27] Endometriosis: What is the Influence of Immune Cells? via openalex

[28] EPIDEMIOLOGY OF ENDOMETRIOSIS via openalex

[29] Estrogen Receptor (ER) Agonists Differentially Regulate Neuroangiogenesis in Peritoneal Endometriosis via the Repellent Factor SLIT3 via openalex

[30] Evaluation of M1 and M2 macrophages in ovarian endometriomas from women affected by endometriosis at different stages of the disease via openalex

[31] Evidence of neurotrophic events due to peritoneal endometriotic lesions via openalex

[32] Expression of inflammatory cytokines in serum and peritoneal fluid from patients with different stages of endometriosis via openalex

[33] Expression of microtubule associated protein 2 and synaptophysin in endometrium: high levels in deep infiltrating endometriosis lesions via openalex

[34] Expression of Nerve Injury-Induced Protein1 (Ninj1) in Endometriosis via openalex

[35] Fractalkine/CX3CR1 Contributes to Endometriosis-Induced Neuropathic Pain and Mechanical Hypersensitivity in Rats via openalex

[36] G-Protein-Coupled Receptor CXCR7 Is Overexpressed in Human and Murine Endometriosis via openalex

[37] Identification and Quantification of Dopamine Receptor 2 in Human Eutopic and Ectopic Endometrium: A Novel Molecular Target for Endometriosis Therapy1 via openalex

[38] Immunological aspects of endometriosis: a review. via openalex

[39] Immunology of endometriosis via openalex

[40] Increased Leptin Levels in Serum and Peritoneal Fluid of Patients with Pelvic Endometriosis via openalex

[41] Inflammation and nerve fiber interaction in endometriotic pain via openalex

[42] Inflammatory Mediators and Pain in Endometriosis: A Systematic Review via openalex

[43] Innervation of ectopic endometrium in a rat model of endometriosis via openalex

[44] Interleukin-17A is present in neutrophils in endometrioma and stimulates the secretion of growth-regulated oncogene–α (Gro-α) from endometrioma stromal cells via openalex

[45] Interleukin‐1β activated c‐FOS transcription factor binds preferentially to a specific allele of the matrix metalloproteinase‐13 promoter and increases susceptibility to endometriosis via openalex

[46] Interleukin (IL)-17A Stimulates IL-8 Secretion, Cyclooxygensase-2 Expression, and Cell Proliferation of Endometriotic Stromal Cells via openalex

[47] In vivo analysis of angiogenesis in endometriosis-like lesions by intravital fluorescence microscopy via openalex

[48] KLFII is an Epigenetic Mediator of DRD2/Dopaminergic Signaling in Endometriosis via openalex

[49] Localization of progesterone-associated endometrial protein mRNA by in-situ hybridization in human pregnancy decidua, endometriosis and borderline endometrioid adenoma via openalex

[50] <p>Research on central sensitization of endometriosis-associated pain: a systematic review of the literature</p> via openalex

[51] Macrophages and nerve fibres in peritoneal endometriosis via openalex

[52] Macrophages display proinflammatory phenotypes in the eutopic endometrium of women with endometriosis with relevance to an infectious etiology of the disease via openalex

[53] Mechanisms of pain in endometriosis via openalex

[54] Nerve fibres in peritoneal endometriosis via openalex

[55] Neuroimmunomodulatory Alterations in Non-Lesional Peritoneum Close to Peritoneal Endometriosis via openalex

[56] Neuropeptides Substance P and Calcitonin Gene Related Peptide Accelerate the Development and Fibrogenesis of Endometriosis via openalex

[57] New developments in the medical treatment of endometriosis via openalex

[58] Pathogenesis of endometriosis: Interaction between Endocrine and inflammatory pathways via openalex

[59] Pathogenesis of Endometriosis: The Origin of Pain and Subfertility via openalex

[60] Pathophysiology of endometriosis-associated pain: A review of pelvic and central nervous system mechanisms via openalex

[61] Peritoneal Fluid Cytokines Reveal New Insights of Endometriosis Subphenotypes via openalex

[62] Peritoneal fluid leptin is associated with chronic pelvic pain but not infertility in endometriosis patients* via openalex

[63] Platelets drive smooth muscle metaplasia and fibrogenesis in endometriosis through epithelial–mesenchymal transition and fibroblast-to-myofibroblast transdifferentiation via openalex

[64] Polarized Macrophages As Potential Anti‐Endometrioid agent via openalex

[65] Rich innervation of deep infiltrating endometriosis via openalex

[66] Role of interleukin-1 receptor type II in the pathogenesis of endometriosis via openalex

[67] Role of interleukin-32 in the pathogenesis of endometriosis: in vitro, human and transgenic mouse data via openalex

[68] Role of the CXCL12–CXCR4 axis in the development of deep rectal endometriosis via openalex

[69] Sensory nerve-derived neuropeptides accelerate the development and fibrogenesis of endometriosis via openalex

[70] Serum and Ectopic Endometrium from Women with Endometriosis Modulate Macrophage M1/M2 Polarization via the Smad2/Smad3 Pathway via openalex

[71] Social psychogenic stress promotes the development of endometriosis in mouse via openalex

[72] Sphingosine I Phosphate (S1P) Increased IL-6 Expression and Cell Growth in Endometriotic Cells via openalex

[73] The effect of growth factors on the proliferation of human endometrial stromal cells in culture via openalex

[74] The Pains of Endometriosis via openalex

[75] The Role of the Immune System in the Development of Endometriosis via openalex

[76] Tumour necrosis factor α concentrations in the peritoneal fluid of infertile women with minimal or mild endometriosis are lower in patients with red lesions only than in patients without red lesions via openalex

[77] W3009375185 via openalex

[78] W3021094484 via openalex

[79] W3092324413 via openalex

[80] W3092539319 via openalex

[81] W3112277875 via openalex

[82] W3115667040 via openalex

[83] W3118462917 via openalex

[84] W3124409908 via openalex

[85] W3134410474 via openalex

[86] W3186834051 via openalex

[87] W3213122472 via openalex

[88] W3216001998 via openalex

[89] W4200608079 via openalex

[90] W4205113655 via openalex

[91] W4207052379 via openalex

[92] W4211081176 via openalex

[93] W4223479460 via openalex

[94] W4281261751 via openalex

[95] W4283457825 via openalex

[96] W4284898089 via openalex

[97] W4297537365 via openalex

[98] W4297990794 via openalex

[99] W6631208994 via openalex

[100] W6661697487 via openalex