Localization of progesterone-associated endometrial protein mRNA by in-situ hybridization in human pregnancy decidua, endometriosis and borderline endometrioid adenoma

M Kämäräinen, Meerit Kämäräinen, I Leivo, Ilmo Leivo, Mervi Julkunen, M Julkunen, Markku Seppälä, M Seppälä
Journal of molecular endocrinology · 1993 · vol. 10(1) , pp. 71–77 · doi:10.1677/jme.0.0100071 · PMID:8452641 · W2000847561
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This study used in-situ hybridization to demonstrate that PAEP mRNA is localized in the glandular epithelium of human decidua, endometriosis, and borderline endometrioid adenoma, varying in abundance during pregnancy.

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Abstract

Progesterone-associated endometrial protein (PAEP) has been isolated from human decidualized endometrium. In-situ hybridization histochemistry was employed to determine the cellular localization of PAEP mRNA in decidua during pregnancy. PAEP mRNA was found to be expressed in the glandular epithelium of decidua spongiosa throughout pregnancy. Substantial variations in the amount of PAEP mRNA during the course of pregnancy were observed, and it was most abundant at the end of the first trimester. We also found that the PAEP gene was expressed in endometriosis and in a borderline endometrioid adenoma. As in decidual tissues, PAEP mRNA in endometriosis was abundant in the glandular compartment.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Decidua Glycoproteins Pregnancy Proteins RNA, Messenger Adenoma Adenoma Adenoma Decidua Endometriosis Endometriosis Endometriosis Female Glycodelin Humans Immunohistochemistry In Situ Hybridization Ovarian Neoplasms Ovarian Neoplasms Ovarian Neoplasms Pregnancy

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Cited by (6)

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License: CC0 · commercial use OK