Localization of progesterone-associated endometrial protein mRNA by in-situ hybridization in human pregnancy decidua, endometriosis and borderline endometrioid adenoma

Kämäräinen M, M Kämäräinen, Meerit Kämäräinen, I Leivo, Ilmo Leivo, Leivo I, Mervi Julkunen, M Julkunen, Julkunen M, Markku Seppälä, M Seppälä, Seppälä M
Journal of molecular endocrinology · 1993 · vol. 10(1) , pp. 71–77 · doi:10.1677/jme.0.0100071 · PMID:8452641 · W2000847561
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This study used in-situ hybridization to demonstrate that PAEP mRNA is localized in the glandular epithelium of human decidua, endometriosis, and borderline endometrioid adenoma, varying in abundance during pregnancy.

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Abstract

Progesterone-associated endometrial protein (PAEP) has been isolated from human decidualized endometrium. In-situ hybridization histochemistry was employed to determine the cellular localization of PAEP mRNA in decidua during pregnancy. PAEP mRNA was found to be expressed in the glandular epithelium of decidua spongiosa throughout pregnancy. Substantial variations in the amount of PAEP mRNA during the course of pregnancy were observed, and it was most abundant at the end of the first trimester. We also found that the PAEP gene was expressed in endometriosis and in a borderline endometrioid adenoma. As in decidual tissues, PAEP mRNA in endometriosis was abundant in the glandular compartment.

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Condition tags

endometriosis

MeSH descriptors

Decidua Glycoproteins Glycoproteins Pregnancy Proteins RNA, Messenger Adenoma Adenoma Adenoma Adenoma Decidua Decidua Endometriosis Endometriosis Endometriosis Endometriosis Female Female Glycodelin Glycodelin Humans

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

Cited by (6)

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License: CC0 · commercial use OK