Increased Leptin Levels in Serum and Peritoneal Fluid of Patients with Pelvic Endometriosis
article
OA: hybrid
CC0
⤵ 50 in-corpus citations
AI-generated summary
This study found significantly increased serum and peritoneal fluid leptin levels in women with pelvic endometriosis compared to controls, with higher levels correlating with earlier disease stages.
One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works
Abstract
Pelvic endometriosis is an immune-related chronic inflammatory disease, characterized by ectopic implants of endometrium in the peritoneal cavity and associated with increased secretion of proinflammatory cytokines and neoangiogenesis. Leptin, the adipocyte-derived hormone, has been shown to have a role in food intake, basal metabolism, and reproductive function. Leptin levels are dynamically regulated, being elevated by inflammatory mediators and reduced by starvation. Leptin itself can influence the proinflammatory immune responses of CD4+ T lymphocytes, and reports have also shown this hormone to be an angiogenic factor in vitro and in vivo. We investigated whether leptin concentrations in serum and peritoneal fluid (PF) differed between 13 patients with different stages of endometriosis and 15 age- and body mass index-matched controls. We found a statistically significant (P <0.05) increase in leptin levels in serum (30.3 +/- 14.8 ng/mL) and PF (35.9 +/- 17.4 ng/mL) of patients with endometriosis, compared with our control population (serum, 15.6 +/- 8.4; PF, 17.5 +/- 7.2 ng/mL). Regression equations, relating leptin to body mass index, were also significantly different in endometriosis patients, compared with controls. Higher levels of leptin were observed in the earlier stages of endometriosis than advanced-stage disease. These data suggest that the proinflammatory and neoangiogenic actions of leptin may contribute to the pathogenesis of endometriosis.
My notes (saved in your browser only)
Condition tags
Citation neighborhood
Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.
Cited by (50)
- The Complex Roles of Adipokines in Polycystic Ovary Syndrome and Endometriosis 2022
- Potential link between the nerve injury-induced protein (Ninjurin) and the pathogenesis of endometriosis 2022
- Non-invasive diagnosis of endometriosis: Immunologic and genetic markers 2022
- Leptin Stimulates Endometriosis Development in Mouse Models 2022
- Associations between body mass index and the surgical phenotype and location of endometriotic lesions 2021
- Body size during adulthood, but not in childhood, associates with endometriosis, specifically in the peritoneal subtype—population‐based life‐course data from birth to late fertile age 2021
- Possible therapeutic effect of royal jelly on endometriotic lesion size, pain sensitivity, and neurotrophic factors in a rat model of endometriosis 2021
- Endometriosis diagnosis and medical treatment: Present and future 2021
- Effect of maternal body mass index on neonatal outcomes in women with endometriosis undergoing IVF 2020
- The relationship between C-reactive protein, carbohydrate antigen 125, and hematological parameters to endometriotic nodule localization in pelvis 2020
- Transforming Growth Factor-beta 1 Involved in the Pathogenesis of Endometriosis through Regulating Expression of Vascular Endothelial Growth Factor under Hypoxia 2017
- Blood biomarkers for the non-invasive diagnosis of endometriosis 2016
- Molecular aspects of endometriosis 2015
- Leptin promotes human endometriotic cell migration and invasion by up-regulating MMP-2 through the JAK2/STAT3 signaling pathway 2015
- Endometriosis and possible inflammation markers 2015
- Novel markers in the diagnostics of endometriomas: Urocortin, ghrelin, and leptin or leukocytes, fibrinogen, and CA-125? 2015
- Inflammation and nerve fiber interaction in endometriotic pain 2014
- Ectopic endometrium-derived leptin produces estrogen-dependent chronic pain in a rat model of endometriosis 2013
- Expression of adiponectin, leptin, and their receptors in ovarian endometrioma 2013
- Gene Expression of Leptin and Long Leptin Receptor Isoform in Endometriosis: A Case-Control Study 2013
- Plasma adipokines and endometriosis risk: a prospective nested case-control investigation from the Nurses' Health Study II 2012
- Leptin receptor is induced in endometriosis and leptin stimulates the growth of endometriotic epithelial cells through the JAK2/STAT3 and ERK pathways 2012
- A high sensitivity assay is more accurate than a classical assay for the measurement of plasma CRP levels in endometriosis 2011
- Deep infiltrating endometriosis is associated with markedly lower body mass index: a 476 case-control study 2011
- Resistin Concentration is Increased in the Peritoneal Fluid of Women with Endometriosis 2010
- Pelvic pain in endometriosis: Painkillers or sport to alleviate symptoms? 2010
- Peripheral biomarkers of endometriosis: a systematic review 2010
- ORIGINAL ARTICLE: Leptin on Peritoneal Macrophages of Patients with Endometriosis 2009
- Elevated ghrelin levels in the peritoneal fluid of patients with endometriosis: associations with vascular endothelial growth factor (VEGF) and inflammatory cytokines 2008
- Association of leptin with inflammatory cytokines and lymphocyte subpopulations in peritoneal fluid of patients with endometriosis 2008
- Intraperitoneal inflammation decreases endometriosis in a mouse model 2008
- Peritoneal fluid and serum leptin concentrations in women with primary infertility 2008
- Ablation of Leptin Signaling Disrupts the Establishment, Development, and Maintenance of Endometriosis-Like Lesions in a Murine Model 2007
- Aberrant Expression of Leptin in Human Endometriotic Stromal Cells Is Induced by Elevated Levels of Hypoxia Inducible Factor-1α 2007
- Inflammatory markers in endometriosis: reduced peritoneal neutrophil response in minimal endometriosis 2007
- Decreased peritoneal concentrations of interleukin-15 in women with advanced stage endometriosis 2006
- Interleukin-10 gene promoter polymorphisms and their protein production in peritoneal fluid in patients with endometriosis 2006
- Serum levels of VEGF and TNF-α and their association with C-reactive protein in patients with endometriosis 2005
- Peritoneal fluid leptin is associated with chronic pelvic pain but not infertility in endometriosis patients* 2005
- Endometrial leptin and leptin receptor expression in women with severe/moderate endometriosis 2004
- Leptin is not involved in the pathophysiology of endometriosis-related infertility 2004
- Noninvasive diagnosis of endometriosis: the role of imaging and markers 2003
- The role of leptin in the development of tumours of female genital organs 2003
- How Does Endometriosis Cause Infertility? 2003
- Endometriosis: a uterine disease with extrauterine lesions? 2003
- Pathogenesis of endometriosis: natural immunity dysfunction or autoimmune disease? 2003
- Three‐dimensional power Doppler imaging of ovarian stromal blood flow in women with endometriosis undergoing <i>in vitro</i> fertilization 2003
- Peritoneal Fluid Concentrations of Ciliary Neurotrophic Factor, a gp130 Cytokine, in Women with Endometriosis 2003
- Increased concentrations of cathepsin D in peritoneal fluid from women with endometriosis 2001
- Leptin in Obstetrics and Gynecology: 2001
Source provenance
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0
· commercial use OK